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. 1974 Sep;71(9):3758–3762. doi: 10.1073/pnas.71.9.3758

Regulation of the Fatty Acid Composition of the Membrane Phospholipids of Escherichia coli

John E Cronan Jr 1
PMCID: PMC433856  PMID: 4610585

Abstract

An increase in the dosage of the fabA gene, which codes for the enzyme β-hydroxydecanoyl thioesterase, causes an increase in the unsaturated fatty acyl content of the phospholipids. This increase is small in cells growing at a constant temperature. However, if cells grown at 37 or 42° are shifted to 15°, the rate of unsaturated fatty acyl moiety synthesis approaches twice the rate of a normal strain. These results indicate that the ratio of unsaturated to saturated fatty acyl groups in phospholipids is partially determined by the levels of at least this fatty acid biosynthetic enzyme.

Keywords: gene dosage, enzyme levels

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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