Abstract
In vivo skin testing and in vitro lymphocyte blastogenesis were evaluated in a young adult population as methods for detecting cellular immunity to Sporotrichum schenckii. Similar procedures for Candida albicans and Coccidioides immitis were also investigated. 5 of 143 subjects had positive skin tests and 14 had positive blastogenic responses to S. schenckii. These 14 subjects also exhibited unusually high responses to C. albicans in vitro and 11 of the 14 were female. Data demonstrated a correlation coefficient of 0.89 when comparing the blastogenic assays for S. schenckii and C. albicans, suggesting cross antigenicity. Intact cellular immune mechanisms in combination with exposure to C. albicans may protect the host from systemic infection with S. schenckii. Although a limited number of subjects were studied, as a group, females had more vigorous cellular immune responses to C. albicans than males. The rare occurence of sporothrix infection in females as compared to males may be the result of antigenic stimulation from commonly observed vaginal colonization with C. albicans. The present data indirectly support this hypothesis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Karlin J. V., Nielsen H. S., Jr Serologic aspects of sporotrichosis. J Infect Dis. 1970 Mar;121(3):316–327. doi: 10.1093/infdis/121.3.316. [DOI] [PubMed] [Google Scholar]
- Lynch P. J., Voorhees J. J., Harrell E. R. Systemic sporotrichosis. Ann Intern Med. 1970 Jul;73(1):23–30. doi: 10.7326/0003-4819-73-1-23. [DOI] [PubMed] [Google Scholar]
- Orr E. R., Riley H. D., Jr Sporotrichosis in childhood: report of ten cases. J Pediatr. 1971 Jun;78(6):951–957. doi: 10.1016/s0022-3476(71)80424-9. [DOI] [PubMed] [Google Scholar]
- Quie P. G., Chilgren R. A. Acute disseminated and chronic mucocutaneous candidiasis. Semin Hematol. 1971 Jul;8(3):227–242. [PubMed] [Google Scholar]
- Roberts G. D., Larsh H. W. The serologic diagnosis of extracutaneous sporotrichosis. Am J Clin Pathol. 1971 Nov;56(5):597–600. doi: 10.1093/ajcp/56.5.597. [DOI] [PubMed] [Google Scholar]
- Steele R. W., Hensen S. A., Vincent M. M., Fuccillo D. A., Bellanti J. A. A 51 Cr microassay technique for cell-mediated immunity to viruses. J Immunol. 1973 Jun;110(6):1502–1510. [PubMed] [Google Scholar]
- Steele R. W., Hensen S. A., Vincent M. M., Fuccillo D. A., Bellanti J. A. Development of specific cellular and humoral immune responses in children immunized with live rubella virus vaccine. J Infect Dis. 1974 Nov;130(5):449–453. doi: 10.1093/infdis/130.5.449. [DOI] [PubMed] [Google Scholar]
- Thorsby E. Cell specific and common antigens on human granulocytes and lymphocytes demonstrated with cytotoxic hetero-antibodies. Vox Sang. 1967 Aug;13(2):194–206. doi: 10.1111/j.1423-0410.1967.tb03949.x. [DOI] [PubMed] [Google Scholar]
- Welsh R. D., Dolan C. T. Sporothrix whole yeast agglutination test: low-titer reactions of sera of subjects not known to have sporotrichosis. Am J Clin Pathol. 1973 Jan;59(1):82–85. doi: 10.1093/ajcp/59.1.82. [DOI] [PubMed] [Google Scholar]
- Wilson D. E., Mann J. J., Bennett J. E., Utz J. P. Clinical features of extracutaneous sporotrichosis. Medicine (Baltimore) 1967 May;46(3):265–279. doi: 10.1097/00005792-196705000-00002. [DOI] [PubMed] [Google Scholar]