Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1955 Nov;34(11):1639–1646. doi: 10.1172/JCI103217

17 α-HYDROXYPROGESTERONE AND 21-DESOXYHYDROCORTISONE; THEIR METABOLISM AND POSSIBLE ROLE IN CONGENITAL ADRENAL VIRILISM 1

Joseph W Jailer 1,2,3, Jay J Gold 1,2,3, Raymond Vande Wiele 1,2,3, Seymour Lieberman 1,2,3
PMCID: PMC438744  PMID: 13271547

Full text

PDF
1642

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTTER F. C., ALBRIGHT F., FORBES A. P., LEAF A., DEMPSEY E., CARROLL E. The effects of adrenocorticotropic hormone and cortisone in the adrenogenital syndrome associated with congenital adrenal hyperplasia: an attempt to explain and correct its disordered hormonal pattern. J Clin Invest. 1951 Mar;30(3):237–251. doi: 10.1172/JCI102438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BASTENIE P. A., FRANCKSON J. R. M., VERBIEST M., KOVACS L., FLAMAND C. Cortisone treatment in adrenogenital syndrome. Lancet. 1953 May 9;1(6767):915–918. doi: 10.1016/s0140-6736(53)92059-5. [DOI] [PubMed] [Google Scholar]
  3. BAYLISS R. I., BROADBENT I. E., STEINBECK A. W. Congenital adrenal hyperplasia; effects of corticotrophin and tetrahydrocortisone. Lancet. 1954 Feb 27;266(6809):434–435. doi: 10.1016/s0140-6736(54)91139-3. [DOI] [PubMed] [Google Scholar]
  4. BONGIOVANNI A. M., CLAYTON G. W., Jr A simplified method for the routine determination of pregnanediol and pregnanetriol in urine. Bull Johns Hopkins Hosp. 1954 Apr;94(4):180–186. [PubMed] [Google Scholar]
  5. BONGIOVANNI A. M., EBERLEIN W. R., CARA J. Studies on the metabolism of adrenal steroids in the adrenogenital syndrome. J Clin Endocrinol Metab. 1954 Apr;14(4):409–422. doi: 10.1210/jcem-14-4-409. [DOI] [PubMed] [Google Scholar]
  6. BONGIOVANNI A. M., EBERLEIN W. R., CARA J. Studies on the metabolism of adrenal steroids in the adrenogenital syndrome. J Clin Endocrinol Metab. 1954 Apr;14(4):409–422. doi: 10.1210/jcem-14-4-409. [DOI] [PubMed] [Google Scholar]
  7. BURSTEIN S., SAVARD K., DORFMAN R. I. The in vivo metabolism of 21-desoxycortisone. Endocrinology. 1953 Sep;53(3):267–273. doi: 10.1210/endo-53-3-267. [DOI] [PubMed] [Google Scholar]
  8. CHRISTY N. P., WALLACE E. Z., JAILER J. W. The effect of intravenously-administered ACTH on plasma 17,21-dihydroxy-20-ketosteroids in normal individuals and in patients with disorders of the adrenal cortex. J Clin Invest. 1955 Jun;34(6):899–906. doi: 10.1172/JCI103146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DEL GRECO F., MASSON G. M. C., CORCORAN A. C. Effects of C17-hydroxysteroids on urinary 17-ketosteroids in the rat. Proc Soc Exp Biol Med. 1952 Jun;80(2):354–357. doi: 10.3181/00379727-80-19620. [DOI] [PubMed] [Google Scholar]
  10. DINGEMANSE E., HUIS IN'T VELD L. G., HARTOGH-KATZ S. L. Clinical method for the chromatographic colorimetric determination of urinary 17-ketosteroids. II. Normal adults. J Clin Endocrinol Metab. 1952 Jan;12(1):66–85. doi: 10.1210/jcem-12-1-66. [DOI] [PubMed] [Google Scholar]
  11. DORFMAN R. I., HAYANO M. The action of adrenal homogenates on progesterone, 17-hydroxyprogesterone and 21-desoxycortisone. Arch Biochem Biophys. 1952 Mar;36(1):237–239. doi: 10.1016/0003-9861(52)90397-4. [DOI] [PubMed] [Google Scholar]
  12. FORBES A. P., ALBRIGHT F. A comparison of the 17-ketosteroid excretion in Cushing's syndrome associated with adrenal tumor and with adrenal hyperplasia. J Clin Endocrinol Metab. 1951 Sep;11(9):926–935. doi: 10.1210/jcem-11-9-926. [DOI] [PubMed] [Google Scholar]
  13. JAILER J. H., LOUCHART J., CAHILL G. F. Adrenal virilism. II. Metabolic studies. J Clin Invest. 1952 Oct;31(10):880–884. doi: 10.1172/JCI102675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. JAILER J. W., LOUCHART J., CAHILL G. F. Adrenal virilism. I. Diagnostic considerations and treatment. J Am Med Assoc. 1952 Oct 11;150(6):575–579. doi: 10.1001/jama.1952.03680060047013. [DOI] [PubMed] [Google Scholar]
  15. JAILER J. W. Virilism. Bull N Y Acad Med. 1953 May;29(5):377–394. [PMC free article] [PubMed] [Google Scholar]
  16. KELLEY V. C., ELY R. S., RAILE R. B. Metabolic studies in patients with congenital adrenal hyperplasia; effects of cortisone therapy. J Clin Endocrinol Metab. 1952 May;12(9):1140–1162. doi: 10.1210/jcem-12-9-1140. [DOI] [PubMed] [Google Scholar]
  17. LAKSHMANAN T. K., LIEBERMAN S. An improved method of gradient elution chromatography and its application to the separation of urinary ketosteroids. Arch Biochem Biophys. 1954 Nov;53(1):258–281. doi: 10.1016/0003-9861(54)90250-7. [DOI] [PubMed] [Google Scholar]
  18. Lewis R. A., Wilkins L. THE EFFECT OF ADRENOCORTICOTROPHIC HORMONE IN CONGENITAL ADRENAL HYPERPLASIA WITH VIRILISM AND IN CUSHING'S SYNDROME TREATED WITH METHYL TESTOSTERONE. J Clin Invest. 1949 Mar;28(2):394–400. doi: 10.1172/JCI102082. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MEYER A. S., RODGERS O. G., PINCUS G. Cow adrenal perfusion of 21-desoxycortisone. Acta Endocrinol (Copenh) 1954 Aug;16(4):293–299. doi: 10.1530/acta.0.0160293. [DOI] [PubMed] [Google Scholar]
  20. POLLEY H. F., MASON H. L. Rheumatoid arthritis; effects of certain steroids other than cortisone and of some adrenal cortex extracts. J Am Med Assoc. 1950 Aug 26;143(17):1474–1481. doi: 10.1001/jama.1950.02910520016007. [DOI] [PubMed] [Google Scholar]
  21. SYNDOR K. L., KELLEY V. C., RAILE R. B., ELY R. S., SAYERS G. Blood adrenocorticotrophin in children with congenital adrenal hyperplasia. Proc Soc Exp Biol Med. 1953 Apr;82(4):695–697. doi: 10.3181/00379727-82-20222. [DOI] [PubMed] [Google Scholar]
  22. WILKINS L., LEWIS R. A., KLEIN R., ROSEMBERG E. The suppression of androgen secretion by cortisone in a case of congenital adrenal hyperplasia. Bull Johns Hopkins Hosp. 1950 Apr;86(4):249–252. [PubMed] [Google Scholar]
  23. ZONDEK B., FINKELSTEIN M. A neutral fluorogenic substance in human urine and its increased excretion in pregnancy and pseudohermaphroditism. Acta Endocrinol (Copenh) 1952 Dec;11(4):297–305. doi: 10.1530/acta.0.0110297. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES