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. 1994 May 24;91(11):5027–5029. doi: 10.1073/pnas.91.11.5027

An algorithm to generate low-resolution protein tertiary structures from knowledge of secondary structure.

A Monge 1, R A Friesner 1, B Honig 1
PMCID: PMC43923  PMID: 8197177

Abstract

An algorithm is described to assemble the three-dimensional fold of a protein starting from its secondary structure. A reduced representation of the polypeptide chain is used together with a crude potential based on pair hydrophobicities. The method is shown to be successful in locating the native topology for two 4-alpha-helix bundles, myohemerythrin and cytochrome b-562.

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Selected References

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