Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1964 Aug;43(8):1668–1676. doi: 10.1172/JCI105042

Renal Tubular Effects of Hydrocortisone and Aldosterone in Normal Hydropenic Man: Comment on Sites of Action *

Stuart L Yunis 1,†, D Danny Bercovitch 1,†, Richard M Stein 1, Marvin F Levitt 1, Marvin H Goldstein 1
PMCID: PMC441966  PMID: 14201550

Full text

PDF
1671

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARGER A. C., BERLIN R. D., TULENKO J. F. Infusion of aldosterone, 9-alpha-fluorohydrocortisone and antidiuretic hormone into the renal artery of normal and adrenalectomized, unanesthetized dogs: effect on electrolyte and water excretion. Endocrinology. 1958 Jun;62(6):804–815. doi: 10.1210/endo-62-6-804. [DOI] [PubMed] [Google Scholar]
  2. BARTTER F. C. The role of aldosterone in normal homeostasis and in certain disease states. Metabolism. 1956 Jul;5(4):369–383. [PubMed] [Google Scholar]
  3. BERLINER R. W., KENNEDY T. J., Jr, HILTON J. G. Renal mechanisms for excretion of potassium. Am J Physiol. 1950 Aug 1;162(2):348–367. doi: 10.1152/ajplegacy.1950.162.2.348. [DOI] [PubMed] [Google Scholar]
  4. BERLINER R. W., LEVINSKY N. G., DAVIDSON D. G., EDEN M. Dilution and concentration of the urine and the action of antidiuretic hormone. Am J Med. 1958 May;24(5):730–744. doi: 10.1016/0002-9343(58)90377-2. [DOI] [PubMed] [Google Scholar]
  5. CRABBE J. The role of aldosterone in the renal concentration mechanism, in man. Clin Sci. 1962 Aug;23:39–46. [PubMed] [Google Scholar]
  6. DETTBARN W. D., GROSS F. Water and salt loading in adrenalectomised dogs treated with cortexone, aldosterone, and 9alpha-fluorocortisol. Acta Endocrinol (Copenh) 1956 Aug;22(4):335–370. doi: 10.1530/acta.0.0220335. [DOI] [PubMed] [Google Scholar]
  7. DINGMAN J. F., FINKENSTAEDT J. T., LAIDLAW J. C., RENOLD A. E., JENKINS D., MERRILL J. P., THORN G. W. Influence of intravenously administered adrenal steroids on sodium and water excretion in normal and Addisonian subjects. Metabolism. 1958 Sep;7(5):608–623. [PubMed] [Google Scholar]
  8. GARROD O., BURSTON R. A. The diuretic response to ingested water in Addison's disease and panhypopituitarism and the effect of cortisone thereon. Clin Sci. 1952 May;11(2):113–128. [PubMed] [Google Scholar]
  9. GARROD O., DAVIES S. A., CAHILL G., Jr The action of cortisone and desoxycorticosterone acetate on glomerular filtration rate and sodium and water exchange in the adrenalectomized dog. J Clin Invest. 1955 Jun;34(6):761–776. doi: 10.1172/JCI103131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GILL J. R., Jr, GANN D. S., BARTTER F. C. Restoration of water diuresis in addisonian patients by expansion of the volume of extracellular fluid. J Clin Invest. 1962 May;41:1078–1085. doi: 10.1172/JCI104558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GOODMAN B., COHEN J. A., LEVITT M. F., KAHN M. RENAL CONCENTRATION IN THE NORMAL DOG: EFFECT OF AN ACUTE REDUCTION IN SALT EXCRETION. Am J Physiol. 1964 May;206:1123–1130. doi: 10.1152/ajplegacy.1964.206.5.1123. [DOI] [PubMed] [Google Scholar]
  12. JAENIKE J. R. Acute effects of the administration of vasopressin during water diuresis in the dog. J Clin Invest. 1963 Feb;42:161–170. doi: 10.1172/JCI104702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. JAENIKE J. R. The influence of vasopressin on the permeability of the mammalian collecting duct to urea. J Clin Invest. 1961 Jan;40:144–151. doi: 10.1172/JCI104228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. JAENIKE J. R. Urea enhancement of water reabsorption in the renal medulla. Am J Physiol. 1960 Dec;199:1205–1210. doi: 10.1152/ajplegacy.1960.199.6.1205. [DOI] [PubMed] [Google Scholar]
  15. JICK H., SNYDER J. G., FINKELSTEIN E. M., COHEN J. L., MOORE E. W., MORRISON R. S. ON THE RENAL SITE AND MODE OF ACTION OF GLUCOCORTICOID IN CIRRHOSIS. J Clin Invest. 1963 Oct;42:1561–1568. doi: 10.1172/JCI104841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. KEKWICK A., PAWAN G. L. Oral aldosterone; effect in a case of Addison's disease. Lancet. 1954 Jul 24;267(6830):162–164. doi: 10.1016/s0140-6736(54)90138-5. [DOI] [PubMed] [Google Scholar]
  17. KLEEMAN C. R., MAXWELL M. H., ROCKNEY R. E. Mechanisms of impaired water excretion in adrenal and pituitary insufficiency. I. The role of altered glomerular filtration rate and solute excretion. J Clin Invest. 1958 Dec;37(12):1799–1808. doi: 10.1172/JCI103773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. KNIGHT R. P., Jr, KORNFELD D. S., GLASER G. H., BONDY P. K. Effects of intravenous hydrocortisone on electrolytes of serum and urine in man. J Clin Endocrinol Metab. 1955 Feb;15(2):176–181. doi: 10.1210/jcem-15-2-176. [DOI] [PubMed] [Google Scholar]
  19. LASSITER W. E., GOTTSCHALK C. W., MYLLE M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol. 1961 Jun;200:1139–1147. doi: 10.1152/ajplegacy.1961.200.6.1139. [DOI] [PubMed] [Google Scholar]
  20. LEVINSKY N. G., BERLINER R. W. The role of urea in the urine concentrating mechanism. J Clin Invest. 1959 May;38(5):741–748. doi: 10.1172/JCI103854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LEVINSKY N. G., DAVIDSON D. G., BERLINER R. W. Effects of reduced glomerular filtration on urine concentration in the presence of antidiuretic hormone. J Clin Invest. 1959 May;38(5):730–740. doi: 10.1172/JCI103853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. LEVITT M. F., LEVY M. S., POLIMEROS D. The effect of a fall in filtration rate on solute and water excretion in hydropenic man. J Clin Invest. 1959 Mar;38(3):463–473. doi: 10.1172/JCI103822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. LINDEMAN R. D., VAN BUREN H. C., RAISZ L. G. Effects of steroids on water diuresis and vasopressin sensitivity. J Clin Invest. 1961 Jan;40:152–158. doi: 10.1172/JCI104229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MAUDE D. L., WESSON L. G., Jr RENAL WATER REABSORPTION DURING SALINE AND UREA OSMOTIC DIURESIS IN THE DOG. Am J Physiol. 1963 Sep;205:477–482. doi: 10.1152/ajplegacy.1963.205.3.477. [DOI] [PubMed] [Google Scholar]
  25. MILLS J. N., THOMAS S., WILLIAMSON K. S. The acute effect of hydrocortisone, deoxycorticosterone and aldosterone upon the excretion of sodium, potassium and acid by the human kidney. J Physiol. 1960 May;151:312–331. doi: 10.1113/jphysiol.1960.sp006440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. MILLS J. N., THOMAS S., WILLIAMSON K. S. The effects of intravenous aldosterone and hydrocortisone on the urinary electrolytes of the recumbent human subject. J Physiol. 1961 May;156:415–423. doi: 10.1113/jphysiol.1961.sp006684. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. OLEESKY S., STANBURY S. W. Effect of oral cortisone on water diuresis in Addison's disease and hypopituitarism. Lancet. 1951 Oct 13;2(6685):664–666. doi: 10.1016/s0140-6736(51)92932-7. [DOI] [PubMed] [Google Scholar]
  28. PRUNTY F. T., McSWINEY R. R., MILLS I. H., SMITH M. A. The effects of aldosterone in Addison's disease and adrenal pseudohermaphroditism. Lancet. 1954 Sep 25;267(6839):620–624. doi: 10.1016/s0140-6736(54)90402-x. [DOI] [PubMed] [Google Scholar]
  29. RAISZ L. G., MCNEELY W. F., SAXON L., ROSENBAUM J. D. The effects of cortisone and hydrocortisone on water diuresis and renal function in man. J Clin Invest. 1957 Jun;36(6 Pt 1):767–779. doi: 10.1172/JCI103481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. SLESSOR A. Studies concerning the mechanism of water retention in Addison's disease and in hypopituitarism. J Clin Endocrinol Metab. 1951 Jul;11(7):700–723. doi: 10.1210/jcem-11-7-700. [DOI] [PubMed] [Google Scholar]
  31. STEINMETZ P. R., SMITH H. W. UREA AND THE RENAL CONCENTRATING OPERATION IN MAN. Am J Med. 1963 Dec;35:727–736. doi: 10.1016/0002-9343(63)90236-5. [DOI] [PubMed] [Google Scholar]
  32. STEIN R. M., LEVITT B. H., GOLDSTEIN M. H., PORUSH J. G., EISNER G. M., LEVITT M. F. The effects of salt restriction on the renal concentrating operation in normal, hydropenic man. J Clin Invest. 1962 Dec;41:2101–2111. doi: 10.1172/JCI104668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. SULLIVAN L. P., WILDE W. S., MALVIN R. L. Renal transport sites for K, H and NH3. Effect of impermeant anions on their transport. Am J Physiol. 1960 Feb;198:244–254. doi: 10.1152/ajplegacy.1960.198.2.244. [DOI] [PubMed] [Google Scholar]
  34. Sonnenblick E. H., Cannon P. J., Laragh J. H. THE NATURE OF THE ACTION OF INTRAVENOUS ALDOSTERONE: EVIDENCE FOR A ROLE OF THE HORMONE IN URINARY DILUTION. J Clin Invest. 1961 Jun;40(6):903–913. doi: 10.1172/JCI104329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. ULLRICH K. J., SCHMIDT-NIELSON B., O'DELL R., PEHLING G., GOTTSCHALK C. W., LASSITER W. E., MYLLE M. Micropuncture study of composition of proximal and distal tubular fluid in rat kidney. Am J Physiol. 1963 Apr;204:527–531. doi: 10.1152/ajplegacy.1963.204.4.527. [DOI] [PubMed] [Google Scholar]
  36. VANDER A. J., MALVIN R. L., WILDE W. S., McMURRAY V. M., LAPIDES J., SULLIVAN L. P. Effects of adrenalectomy and aldosterone on proximal and distal tubular sodium reabsorption. Proc Soc Exp Biol Med. 1958 Nov;99(2):323–325. doi: 10.3181/00379727-99-24338. [DOI] [PubMed] [Google Scholar]
  37. VANDER A. J., WILDE W. S., MALVIN R. L. Stop flow analysis of aldosterone and steroidal antagonist SC-8109 on renal tubular sodium transport kinetics. Proc Soc Exp Biol Med. 1960 Mar;103:525–527. doi: 10.3181/00379727-103-25581. [DOI] [PubMed] [Google Scholar]
  38. WIRZ H., HARGITAY B., KUHN W. Lokalisation des Konzentrierungsprozesses in der Niere durch direkte Kryoskopie. Helv Physiol Pharmacol Acta. 1951 Jun;9(2):196–207. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES