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. 1967 Apr;46(4):580–589. doi: 10.1172/JCI105559

The Anticoagulant Activity of Lysosomal Cationic Proteins from Polymorphonuclear Leukocytes *

Hussain I Saba 1,2,†, Harold R Roberts 1,2, John C Herion 1,2,‡
PMCID: PMC442041  PMID: 6021205

Abstract

A cationic protein fraction from rabbit polymorphonuclear leukocyte lysosomes has been shown to exert a potent anticoagulant effect on human blood in vitro. The anticoagulant activity is detectable in the whole blood clotting time, the recalcification time of platelet-rich plasma, the prothrombin time, the partial thromboplastin time, and the thromboplastin generation test. The lysosomal cationic proteins do not inhibit any of the known specific procoagulants. They appear to inhibit clotting by blocking the formation of intrinsic thromboplastin possibly by interfering with the role of phospholipids in the reaction involving Factors V and X and calcium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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