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. 1994 Jul 19;91(15):6819–6823. doi: 10.1073/pnas.91.15.6819

The history of a genetic system.

A Popadić 1, W W Anderson 1
PMCID: PMC44289  PMID: 7518922

Abstract

Although the chromosomal polymorphism for inversions in Drosophila pseudoobscura is one of the best studied systems in population genetics, the identity of the ancestral gene arrangement has remained unresolved for more than 50 years. There are more than 40 gene arrangements, and 4 of them (Standard, Hypothetical, Santa Cruz, and Tree Line) have been considered as candidates for the ancestral type. We propose a framework of competing hypotheses to distinguish among the alternatives. Two conclusions come from contrasting each hypothesis with the results from DNA sequencing and restriction mapping. First, not only Standard but also Hypothetical can be excluded as the ancestral gene arrangement. Second, although either Tree Line or Santa Cruz could be the ancestral type, the available data provide greater support for Santa Cruz.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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