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. 1992 Feb;89(2):681–685. doi: 10.1172/JCI115635

T cell receptor repertoire of infiltrating T cells in lips of Sjögren's syndrome patients.

T Sumida 1, F Yonaha 1, T Maeda 1, E Tanabe 1, T Koike 1, H Tomioka 1, S Yoshida 1
PMCID: PMC442902  PMID: 1531348

Abstract

Infiltrating T cells around salivary glands in the lips of Sjögren's syndrome (SjS) patients are crucial in the pathogenesis of this disease. To analyze the nature of infiltrating T cells, their T cell receptor repertoire was examined with quantitative polymerase chain reaction. The repertoire of V beta transcripts in lips of SjS was not restricted; however, the V beta 2 and V beta 13 genes were predominantly expressed on the T cells of lip specimens in six and four of seven lips, respectively. Predominance of these genes was specific in lips because no predominant V beta transcripts were found in lips from healthy subjects and PBLs from SjS patients. These results indicated that the V beta 2- and V beta 13-positive T cells expanded specifically and preferentially in SjS lips, thereby suggesting the possible role in triggering the autoimmunity of this disease.

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Selected References

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