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. 1972 Jan;1(1):12–16. doi: 10.1128/aac.1.1.12

Stimulation of the Hexose Monophosphate Shunt in Human Neutrophils by Ascorbic Acid: Mechanism of Action

Lawrence R DeChatelet 1, M Robert Cooper 1, Charles E McCall 1
PMCID: PMC444158  PMID: 4670425

Abstract

The addition of either ascorbic acid or dehydroascorbic acid to a suspension of polymorphonuclear leukocytes caused a dramatic increase in the resting hexose monophosphate shunt activity. A sequence of reactions involving dehydroascorbate, reduced glutathione, and reduced nicotinamide adenine dinucleotide phosphate is described to explain this stimulation. This sequence could provide an alternate method of producing H2O2 and a bactericidal mechanism which is independent of myeloperoxidase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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