Abstract
Amphotericin B was found to potentiate the antifungal effects of mycophenolic acid glucuronide, tetracycline, and actinomycin D by increasing the penetration of these antibiotics through the fungal cytoplasmic membrane. Because the fungi were over 100 times more susceptible than animal cells to these effects of amphotericin B, these observations might have clinical application.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Battaner E., Vazquez D. Inhibitors of protein synthesis by ribosomes of the 80-S type. Biochim Biophys Acta. 1971 Dec 16;254(2):316–330. doi: 10.1016/0005-2787(71)90840-9. [DOI] [PubMed] [Google Scholar]
- Franklin T. J., Cook J. M. The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem J. 1969 Jul;113(3):515–524. doi: 10.1042/bj1130515. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartwell L. H. Macromolecule synthesis in temperature-sensitive mutants of yeast. J Bacteriol. 1967 May;93(5):1662–1670. doi: 10.1128/jb.93.5.1662-1670.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kinsky S. C. Antibiotic interaction with model membranes. Annu Rev Pharmacol. 1970;10:119–142. doi: 10.1146/annurev.pa.10.040170.001003. [DOI] [PubMed] [Google Scholar]
- Medoff G., Comfort M., Kobayashi G. S. Synergistic action of amphotericin B and 5-fluorocytosine against yeast-like organisms. Proc Soc Exp Biol Med. 1971 Nov;138(2):571–574. doi: 10.3181/00379727-138-35943. [DOI] [PubMed] [Google Scholar]
- Medoff G., Kobayashi G. S., Kwan C. N., Schlessinger D., Venkov P. Potentiation of rifampicin and 5-fluorocytosine as antifungal antibiotics by amphotericin B (yeast-membrane permeability-ribosomal RNA-eukaryotic cell-synergism). Proc Natl Acad Sci U S A. 1972 Jan;69(1):196–199. doi: 10.1073/pnas.69.1.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sweeney M. J., Hoffmann D. H., Poore G. A. Possible in situ activation of mycophenolic acid by beta-glucuronidase. Cancer Res. 1971 Apr;31(4):477–478. [PubMed] [Google Scholar]