Abstract
Cephamycin A was found to be more active in vivo than cephamycin B. In comparison with cephamycin C, cephamycin A was more active against gram-positive organisms but less active against gram-negative organisms. Given subcutaneously, cephamycin C had good in vivo gram-negative activity, comparing favorably with cephalothin and cephaloridine against cephalosporin-susceptible organisms. In general, against the gram-negative organisms, it was more active than cephalothin or cephalosporin C and about as active as cephaloridine. In addition, cephamycin C protected mice against β-lactamase-producing Proteus cultures, including clinically isolated strains. The compound is remarkably nontoxic. Cephamycin C was detected in the serum and recovered from the urine of treated mice to about the same extent as cephaloridine. Like cephaloridine and cephalosporin C, cephamycin C must be excreted mainly by glomerular filtration, because the use of probenecid did not enhance the therapeutic effectiveness nor concentrations of these agents in the sera of treated mice.
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Selected References
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- Kislak J. W., Steinhauer B. W., Finland M. Cephaloridine activity in vitro and absorption and urinary excretion in normal young men. Am J Med Sci. 1966 Apr;251(4):433–448. [PubMed] [Google Scholar]
- Miller A. K., Celozzi E., Pelak B. A., Stapley E. O., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. 3. In vitro studies. Antimicrob Agents Chemother. 1972 Oct;2(4):281–286. doi: 10.1128/aac.2.4.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saslaw S. Cephalosporins. Med Clin North Am. 1970 Sep;54(5):1217–1228. [PubMed] [Google Scholar]
- Stapley E. O., Jackson M., Hernandez S., Zimmerman S. B., Currie S. A., Mochales S., Mata J. M., Woodruff H. B., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n. Antimicrob Agents Chemother. 1972 Sep;2(3):122–131. doi: 10.1128/aac.2.3.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stewart G. T., Boyd J. F., Butcher B. T. The place of the cephalosporins in medicine. Postgrad Med J. 1970 Oct;(Suppl):133–137. [PubMed] [Google Scholar]