Abstract
Axenomycins are a new group of macrolide antibiotics isolated from the fermentation broth of Streptomyces lisandri n.sp. They exhibit anthelmintic activity against tapeworms (Cestoda). Three different fractions, A, B, and D, have been obtained, the most active fraction being axenomycin D. The activities of the axenomycin complex and axenomycin D against Hymenolepis nana in mice, Taenia pisiformis, Dipylidium caninum, and Diphyllobothrium sp. in dogs, and Moniezia expansa, M. benedeni, and Avitellina centripunctata in lambs were studied in experimentally and naturally infected animals. Axenomycins were effective and well tolerated by the oral route. Worm reduction rates after a single oral dose were 90 to 100% with 5 to 10 mg of axenomycin D/kg and 50 to 100% with 20 mg of axenomycin complex/kg.
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Selected References
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- Cassinelli G., Cotta E., D'Amico G., Della Bruna C., Grein A., Mazzoleni R., Ricciardi M. L., Tintinelli R. Thaimycins, new anthelmintic and antiprotozoal antibiotics produced by Streptomyces michiganensis var. amylolyticus var. nova. Arch Mikrobiol. 1970;70(3):197–210. doi: 10.1007/BF00407710. [DOI] [PubMed] [Google Scholar]
- Gibson T. E. Advances in veterinary anthelmintic medication. Adv Parasitol. 1969;7:349–373. doi: 10.1016/s0065-308x(08)60439-x. [DOI] [PubMed] [Google Scholar]
- HAMMILL R. L., HOEHN M. ANTHELMYCIN, A NEW ANTIBIOTIC WITH ANTHELMINTIC PROPERTIES. J Antibiot (Tokyo) 1964 May;17:100–103. [PubMed] [Google Scholar]
- KELLEY G. W., HARRIS L., ALEXANDER M. A., OLSEN L. S. Hygromycin B for removing Thysanosoma actinoides, fringed tapeworms from feedlot lambs. J Am Vet Med Assoc. 1960 May 15;136:505–507. [PubMed] [Google Scholar]
- Keeling J. E. The chemotherapy of cestode infections. Adv Chemother. 1968;3:109–152. [PubMed] [Google Scholar]
- Lämmler G. Chemotherapy of trematode infections. Adv Chemother. 1968;3:153–251. [PubMed] [Google Scholar]
- Probst G. W., Hoehn M. M., Woods B. L. Anthelvencins, new antibiotics with anthelmintic properties. Antimicrob Agents Chemother (Bethesda) 1965;5:789–795. [PubMed] [Google Scholar]
- Ulivelli A. A proposito della terapia antibiotica (con paromomicina) in alcune cestodiasi. G Mal Infett Parassit. 1967 May;19(5):308–310. [PubMed] [Google Scholar]