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. 1973 Sep;4(3):214–221. doi: 10.1128/aac.4.3.214

Bacteriocin of a Group A Streptococcus: Partial Purification and Properties

J R Tagg a,1, R S D Read a, A R McGiven a,2
PMCID: PMC444531  PMID: 4586138

Abstract

The production of bacteriocin-like inhibition by certain strains of group A streptococci was demonstrated during the growth of these organisms on solid nutrient media. Active bacteriocin could not be recovered from broth cultures, possibly because of its inactivation by streptococcal proteinase. The bacteriocin, streptocin A, produced by Streptococcus pyogenes strain FF-22 was partially purified by chemical precipitation and chromatography on carboxymethyl-cellulose. Streptocin A inhibited the growth of various gram-positive organisms but none of a wide range of different gram-negative strains. The bacteriocin was inactivated by proteolytic enzymes and, although labile in alkali, it was extremely stable to heating in mild acids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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