Abstract
Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 μg/ml inhibited six of 13 strains and, at 3 μg/ml, 10 of 13 strains.
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- Bach M. C., Zinner S. H., Wilcox C., Finland M. Efficacy of standard disc-diffusion test as applied to susceptibility of Staphylococcus aureus to tetracycline and minocycline. J Lab Clin Med. 1972 Feb;79(2):316–325. [PubMed] [Google Scholar]
- Barrett F. F., McGehee R. F., Jr, Finland M. Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations. N Engl J Med. 1968 Aug 29;279(9):441–448. doi: 10.1056/NEJM196808292790901. [DOI] [PubMed] [Google Scholar]
- Benner E. J., Kayser F. H. Growing clinical significance of methcillin-resistant Staphylococcus aureus. Lancet. 1968 Oct 5;2(7571):741–744. doi: 10.1016/s0140-6736(68)90947-1. [DOI] [PubMed] [Google Scholar]
- Bernard B., Yin E. J., Simon H. J. Clinical pharmacologic studies with minocycline. J Clin Pharmacol New Drugs. 1971 Sep-Oct;11(5):332–348. [PubMed] [Google Scholar]
- Bulger R. J., Feigl P., Nielson K. Comparison of treatments with several antibiotics in experimental infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 1972 Dec;126(6):674–678. doi: 10.1093/infdis/126.6.674. [DOI] [PubMed] [Google Scholar]
- Carleton J., Phair J. P. The slow bactericidal effect of tetracycline and minocycline on wall-defective staphylococcus. J Infect Dis. 1972 Oct;126(4):457–459. doi: 10.1093/infdis/126.4.457. [DOI] [PubMed] [Google Scholar]
- Drew W. L., Barry A. L., O'Toole R., Sherris J. C. Reliability of the Kirby-Bauer disc diffusion method for detecting methicillin-resistant strains of Staphylococcus aureus. Appl Microbiol. 1972 Aug;24(2):240–247. doi: 10.1128/am.24.2.240-247.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fedorko J., Katz S., Allnoch H. In vitro activity of minocycline, a new tetracycline. Am J Med Sci. 1968 Apr;255:252–258. doi: 10.1097/00000441-196804000-00006. [DOI] [PubMed] [Google Scholar]
- Klastersky J., Daneau D. Bacteriological evaluation of minocycline, a new tetracycline. Chemotherapy. 1972;17(1):51–58. doi: 10.1159/000220838. [DOI] [PubMed] [Google Scholar]
- Leibowitz B. J., Hakes J. L., Cahn M. M., Levy E. J. Doxycycline blood levels in normal subjects after intravenous and oral administration. Curr Ther Res Clin Exp. 1972 Dec;14(12):820–832. [PubMed] [Google Scholar]
- Lorian V. The mode of action of antibiotics on gram-negative bacilli. Arch Intern Med. 1971 Oct;128(4):623–632. [PubMed] [Google Scholar]
- Macdonald H., Kelly R. G., Allen E. S., Noble J. F., Kanegis L. A. Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther. 1973 Sep-Oct;14(5):852–861. doi: 10.1002/cpt1973145852. [DOI] [PubMed] [Google Scholar]
- O'Toole R. D., Drew W. L., Dahlgren B. J., Beaty H. N. An outbreak of methicillin-resistant Staphylococcus aureus infection. Observations in hospital and nursing home. JAMA. 1970 Jul 13;213(2):257–263. [PubMed] [Google Scholar]
- Steigbigel N. H., Reed C. W., Finland M. Absorption and excretion of five tetracycline analogues in normal young men. Am J Med Sci. 1968 May;255:296–312. doi: 10.1097/00000441-196805000-00005. [DOI] [PubMed] [Google Scholar]
- Steigbigel N. H., Reed C. W., Finland M. Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro. Am J Med Sci. 1968 Mar;255:179–195. doi: 10.1097/00000441-196803000-00005. [DOI] [PubMed] [Google Scholar]