Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1974 Oct;6(4):411–414. doi: 10.1128/aac.6.4.411

Activity of Tetracycline, Doxycycline, and Minocycline Against Methicillin-Susceptible and -Resistant Staphylococci

J N Minuth 1,2, T M Holmes 1,2, D M Musher 1,2
PMCID: PMC444661  PMID: 4157335

Abstract

Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 μg/ml inhibited six of 13 strains and, at 3 μg/ml, 10 of 13 strains.

Full text

PDF
412

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach M. C., Zinner S. H., Wilcox C., Finland M. Efficacy of standard disc-diffusion test as applied to susceptibility of Staphylococcus aureus to tetracycline and minocycline. J Lab Clin Med. 1972 Feb;79(2):316–325. [PubMed] [Google Scholar]
  2. Barrett F. F., McGehee R. F., Jr, Finland M. Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations. N Engl J Med. 1968 Aug 29;279(9):441–448. doi: 10.1056/NEJM196808292790901. [DOI] [PubMed] [Google Scholar]
  3. Benner E. J., Kayser F. H. Growing clinical significance of methcillin-resistant Staphylococcus aureus. Lancet. 1968 Oct 5;2(7571):741–744. doi: 10.1016/s0140-6736(68)90947-1. [DOI] [PubMed] [Google Scholar]
  4. Bernard B., Yin E. J., Simon H. J. Clinical pharmacologic studies with minocycline. J Clin Pharmacol New Drugs. 1971 Sep-Oct;11(5):332–348. [PubMed] [Google Scholar]
  5. Bulger R. J., Feigl P., Nielson K. Comparison of treatments with several antibiotics in experimental infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 1972 Dec;126(6):674–678. doi: 10.1093/infdis/126.6.674. [DOI] [PubMed] [Google Scholar]
  6. Carleton J., Phair J. P. The slow bactericidal effect of tetracycline and minocycline on wall-defective staphylococcus. J Infect Dis. 1972 Oct;126(4):457–459. doi: 10.1093/infdis/126.4.457. [DOI] [PubMed] [Google Scholar]
  7. Drew W. L., Barry A. L., O'Toole R., Sherris J. C. Reliability of the Kirby-Bauer disc diffusion method for detecting methicillin-resistant strains of Staphylococcus aureus. Appl Microbiol. 1972 Aug;24(2):240–247. doi: 10.1128/am.24.2.240-247.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fedorko J., Katz S., Allnoch H. In vitro activity of minocycline, a new tetracycline. Am J Med Sci. 1968 Apr;255:252–258. doi: 10.1097/00000441-196804000-00006. [DOI] [PubMed] [Google Scholar]
  9. Klastersky J., Daneau D. Bacteriological evaluation of minocycline, a new tetracycline. Chemotherapy. 1972;17(1):51–58. doi: 10.1159/000220838. [DOI] [PubMed] [Google Scholar]
  10. Leibowitz B. J., Hakes J. L., Cahn M. M., Levy E. J. Doxycycline blood levels in normal subjects after intravenous and oral administration. Curr Ther Res Clin Exp. 1972 Dec;14(12):820–832. [PubMed] [Google Scholar]
  11. Lorian V. The mode of action of antibiotics on gram-negative bacilli. Arch Intern Med. 1971 Oct;128(4):623–632. [PubMed] [Google Scholar]
  12. Macdonald H., Kelly R. G., Allen E. S., Noble J. F., Kanegis L. A. Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther. 1973 Sep-Oct;14(5):852–861. doi: 10.1002/cpt1973145852. [DOI] [PubMed] [Google Scholar]
  13. O'Toole R. D., Drew W. L., Dahlgren B. J., Beaty H. N. An outbreak of methicillin-resistant Staphylococcus aureus infection. Observations in hospital and nursing home. JAMA. 1970 Jul 13;213(2):257–263. [PubMed] [Google Scholar]
  14. Steigbigel N. H., Reed C. W., Finland M. Absorption and excretion of five tetracycline analogues in normal young men. Am J Med Sci. 1968 May;255:296–312. doi: 10.1097/00000441-196805000-00005. [DOI] [PubMed] [Google Scholar]
  15. Steigbigel N. H., Reed C. W., Finland M. Susceptibility of common pathogenic bacteria to seven tetracycline antibiotics in vitro. Am J Med Sci. 1968 Mar;255:179–195. doi: 10.1097/00000441-196803000-00005. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES