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. 1994 Aug 16;91(17):7833–7835. doi: 10.1073/pnas.91.17.7833

Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.

P H Patterson 1
PMCID: PMC44497  PMID: 8058719

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Selected References

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  1. Bamber B. A., Masters B. A., Hoyle G. W., Brinster R. L., Palmiter R. D. Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7839–7843. doi: 10.1073/pnas.91.17.7839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Banner L. R., Patterson P. H. Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7109–7113. doi: 10.1073/pnas.91.15.7109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bartfai T., Schultzberg M. Cytokines in neuronal cell types. Neurochem Int. 1993 May;22(5):435–444. doi: 10.1016/0197-0186(93)90038-7. [DOI] [PubMed] [Google Scholar]
  4. Bazan J. F. Neuropoietic cytokines in the hematopoietic fold. Neuron. 1991 Aug;7(2):197–208. doi: 10.1016/0896-6273(91)90258-2. [DOI] [PubMed] [Google Scholar]
  5. Bienenstock J., Tomioka M., Matsuda H., Stead R. H., Quinonez G., Simon G. T., Coughlin M. D., Denburg J. A. The role of mast cells in inflammatory processes: evidence for nerve/mast cell interactions. Int Arch Allergy Appl Immunol. 1987;82(3-4):238–243. doi: 10.1159/000234197. [DOI] [PubMed] [Google Scholar]
  6. Brown D. R., Quito F. L. Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur J Pharmacol. 1988 Oct 11;155(1-2):159–162. doi: 10.1016/0014-2999(88)90415-3. [DOI] [PubMed] [Google Scholar]
  7. Chalazonitis A., Kalberg J., Twardzik D. R., Morrison R. S., Kessler J. A. Transforming growth factor beta has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor. Dev Biol. 1992 Jul;152(1):121–132. doi: 10.1016/0012-1606(92)90162-a. [DOI] [PubMed] [Google Scholar]
  8. Cheema S. S., Richards L., Murphy M., Bartlett P. F. Leukemia inhibitory factor prevents the death of axotomised sensory neurons in the dorsal root ganglia of the neonatal rat. J Neurosci Res. 1994 Feb 1;37(2):213–218. doi: 10.1002/jnr.490370207. [DOI] [PubMed] [Google Scholar]
  9. Clatterbuck R. E., Price D. L., Koliatsos V. E. Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2222–2226. doi: 10.1073/pnas.90.6.2222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Coulombe J. N., Schwall R., Parent A. S., Eckenstein F. P., Nishi R. Induction of somatostatin immunoreactivity in cultured ciliary ganglion neurons by activin in choroid cell-conditioned medium. Neuron. 1993 May;10(5):899–906. doi: 10.1016/0896-6273(93)90205-6. [DOI] [PubMed] [Google Scholar]
  11. Cunningham E. T., Jr, De Souza E. B. Interleukin 1 receptors in the brain and endocrine tissues. Immunol Today. 1993 Apr;14(4):171–176. doi: 10.1016/0167-5699(93)90281-o. [DOI] [PubMed] [Google Scholar]
  12. Curtis R., Scherer S. S., Somogyi R., Adryan K. M., Ip N. Y., Zhu Y., Lindsay R. M., DiStefano P. S. Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve. Neuron. 1994 Jan;12(1):191–204. doi: 10.1016/0896-6273(94)90163-5. [DOI] [PubMed] [Google Scholar]
  13. Davis S., Aldrich T. H., Valenzuela D. M., Wong V. V., Furth M. E., Squinto S. P., Yancopoulos G. D. The receptor for ciliary neurotrophic factor. Science. 1991 Jul 5;253(5015):59–63. doi: 10.1126/science.1648265. [DOI] [PubMed] [Google Scholar]
  14. Dimitriadou V., Buzzi M. G., Moskowitz M. A., Theoharides T. C. Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells. Neuroscience. 1991;44(1):97–112. doi: 10.1016/0306-4522(91)90253-k. [DOI] [PubMed] [Google Scholar]
  15. Escary J. L., Perreau J., Duménil D., Ezine S., Brûlet P. Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature. 1993 May 27;363(6427):361–364. doi: 10.1038/363361a0. [DOI] [PubMed] [Google Scholar]
  16. Fabry Z., Raine C. S., Hart M. N. Nervous tissue as an immune compartment: the dialect of the immune response in the CNS. Immunol Today. 1994 May;15(5):218–224. doi: 10.1016/0167-5699(94)90247-X. [DOI] [PubMed] [Google Scholar]
  17. Fan G., Katz D. M. Non-neuronal cells inhibit catecholaminergic differentiation of primary sensory neurons: role of leukemia inhibitory factor. Development. 1993 May;118(1):83–93. doi: 10.1242/dev.118.1.83. [DOI] [PubMed] [Google Scholar]
  18. Fann M. J., Patterson P. H. A novel approach to screen for cytokine effects on neuronal gene expression. J Neurochem. 1993 Oct;61(4):1349–1355. doi: 10.1111/j.1471-4159.1993.tb13628.x. [DOI] [PubMed] [Google Scholar]
  19. Fann M. J., Patterson P. H. Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):43–47. doi: 10.1073/pnas.91.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Felten D. L. Neurotransmitter signaling of cells of the immune system: important progress, major gaps. Brain Behav Immun. 1991 Mar;5(1):2–8. doi: 10.1016/0889-1591(91)90003-s. [DOI] [PubMed] [Google Scholar]
  21. Fitzgerald M. Arthritis and the nervous system. Trends Neurosci. 1989 Mar;12(3):86–87. doi: 10.1016/0166-2236(89)90161-6. [DOI] [PubMed] [Google Scholar]
  22. Foreman J. C. Peptides and neurogenic inflammation. Br Med Bull. 1987 Apr;43(2):386–400. doi: 10.1093/oxfordjournals.bmb.a072189. [DOI] [PubMed] [Google Scholar]
  23. Freidin M., Kessler J. A. Cytokine regulation of substance P expression in sympathetic neurons. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3200–3203. doi: 10.1073/pnas.88.8.3200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Friedman B., Scherer S. S., Rudge J. S., Helgren M., Morrisey D., McClain J., Wang D. Y., Wiegand S. J., Furth M. E., Lindsay R. M. Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo. Neuron. 1992 Aug;9(2):295–305. doi: 10.1016/0896-6273(92)90168-d. [DOI] [PubMed] [Google Scholar]
  25. Fukada K. Purification and partial characterization of a cholinergic neuronal differentiation factor. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8795–8799. doi: 10.1073/pnas.82.24.8795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Gearing D. P., Thut C. J., VandeBos T., Gimpel S. D., Delaney P. B., King J., Price V., Cosman D., Beckmann M. P. Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 1991 Oct;10(10):2839–2848. doi: 10.1002/j.1460-2075.1991.tb07833.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gordon J. R., Burd P. R., Galli S. J. Mast cells as a source of multifunctional cytokines. Immunol Today. 1990 Dec;11(12):458–464. doi: 10.1016/0167-5699(90)90176-a. [DOI] [PubMed] [Google Scholar]
  28. Gurney M. E., Yamamoto H., Kwon Y. Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor. J Neurosci. 1992 Aug;12(8):3241–3247. doi: 10.1523/JNEUROSCI.12-08-03241.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Hall A. K., Rao M. S. Cytokines and neurokines: related ligands and related receptors. Trends Neurosci. 1992 Feb;15(2):35–37. doi: 10.1016/0166-2236(92)90022-z. [DOI] [PubMed] [Google Scholar]
  30. Hartung H. P., Toyka K. V. Substance P, the immune system and inflammation. Int Rev Immunol. 1989 Jun;4(3):229–249. doi: 10.3109/08830188909054420. [DOI] [PubMed] [Google Scholar]
  31. Hendry I. A., Murphy M., Hilton D. J., Nicola N. A., Bartlett P. F. Binding and retrograde transport of leukemia inhibitory factor by the sensory nervous system. J Neurosci. 1992 Sep;12(9):3427–3434. doi: 10.1523/JNEUROSCI.12-09-03427.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Ip N. Y., Nye S. H., Boulton T. G., Davis S., Taga T., Li Y., Birren S. J., Yasukawa K., Kishimoto T., Anderson D. J. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell. 1992 Jun 26;69(7):1121–1132. doi: 10.1016/0092-8674(92)90634-o. [DOI] [PubMed] [Google Scholar]
  33. Jonakait G. M. Neural-immune interactions in sympathetic ganglia. Trends Neurosci. 1993 Oct;16(10):419–423. doi: 10.1016/0166-2236(93)90011-a. [DOI] [PubMed] [Google Scholar]
  34. Kimball E. S., Persico F. J., Vaught J. L. Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease. J Immunol. 1988 Nov 15;141(10):3564–3569. [PubMed] [Google Scholar]
  35. Kimball E. S. Substance P, cytokines, and arthritis. Ann N Y Acad Sci. 1990;594:293–308. doi: 10.1111/j.1749-6632.1990.tb40489.x. [DOI] [PubMed] [Google Scholar]
  36. Kishimoto T., Taga T., Akira S. Cytokine signal transduction. Cell. 1994 Jan 28;76(2):253–262. doi: 10.1016/0092-8674(94)90333-6. [DOI] [PubMed] [Google Scholar]
  37. Kowalski M. L., Kaliner M. A. Neurogenic inflammation, vascular permeability, and mast cells. J Immunol. 1988 Jun 1;140(11):3905–3911. [PubMed] [Google Scholar]
  38. Lambracht-Hall M., Dimitriadou V., Theoharides T. C. Migration of mast cells in the developing rat brain. Brain Res Dev Brain Res. 1990 Nov 1;56(2):151–159. doi: 10.1016/0165-3806(90)90077-c. [DOI] [PubMed] [Google Scholar]
  39. Laurenzi M. A., Persson M. A., Dalsgaard C. J., Haegerstrand A. The neuropeptide substance P stimulates production of interleukin 1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide. Scand J Immunol. 1990 Apr;31(4):529–533. doi: 10.1111/j.1365-3083.1990.tb02801.x. [DOI] [PubMed] [Google Scholar]
  40. Leon A., Buriani A., Dal Toso R., Fabris M., Romanello S., Aloe L., Levi-Montalcini R. Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3739–3743. doi: 10.1073/pnas.91.9.3739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Lotz M., Moats T., Villiger P. M. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis. J Clin Invest. 1992 Sep;90(3):888–896. doi: 10.1172/JCI115964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Lotz M., Vaughan J. H., Carson D. A. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science. 1988 Sep 2;241(4870):1218–1221. doi: 10.1126/science.2457950. [DOI] [PubMed] [Google Scholar]
  43. Lütticken C., Wegenka U. M., Yuan J., Buschmann J., Schindler C., Ziemiecki A., Harpur A. G., Wilks A. F., Yasukawa K., Taga T. Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science. 1994 Jan 7;263(5143):89–92. doi: 10.1126/science.8272872. [DOI] [PubMed] [Google Scholar]
  44. Marshall J. S., Gauldie J., Nielsen L., Bienenstock J. Leukemia inhibitory factor production by rat mast cells. Eur J Immunol. 1993 Sep;23(9):2116–2120. doi: 10.1002/eji.1830230911. [DOI] [PubMed] [Google Scholar]
  45. Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature. 1993 Sep 2;365(6441):27–32. doi: 10.1038/365027a0. [DOI] [PubMed] [Google Scholar]
  46. Mayer P., Geissler K., Ward M., Metcalf D. Recombinant human leukemia inhibitory factor induces acute phase proteins and raises the blood platelet counts in nonhuman primates. Blood. 1993 Jun 15;81(12):3226–3233. [PubMed] [Google Scholar]
  47. Metcalf D., Gearing D. P. Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5948–5952. doi: 10.1073/pnas.86.15.5948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Metcalf D., Nicola N. A., Gearing D. P. Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice. Blood. 1990 Jul 1;76(1):50–56. [PubMed] [Google Scholar]
  49. Murphy M., Reid K., Brown M. A., Bartlett P. F. Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons. Development. 1993 Mar;117(3):1173–1182. doi: 10.1242/dev.117.3.1173. [DOI] [PubMed] [Google Scholar]
  50. Nawa H., Yamamori T., Le T., Patterson P. H. Generation of neuronal diversity: analogies and homologies with hematopoiesis. Cold Spring Harb Symp Quant Biol. 1990;55:247–253. doi: 10.1101/sqb.1990.055.01.027. [DOI] [PubMed] [Google Scholar]
  51. Nilsson G., Alving K., Ahlstedt S., Hökfelt T., Lundberg J. M. Peptidergic innervation of rat lymphoid tissue and lung: relation to mast cells and sensitivity to capsaicin and immunization. Cell Tissue Res. 1990 Oct;262(1):125–133. doi: 10.1007/BF00327753. [DOI] [PubMed] [Google Scholar]
  52. O'Dorisio M. S. Neuropeptides and gastrointestinal immunity. Am J Med. 1986 Dec 22;81(6B):74–82. doi: 10.1016/0002-9343(86)90587-5. [DOI] [PubMed] [Google Scholar]
  53. Oppenheim R. W., Prevette D., Yin Q. W., Collins F., MacDonald J. Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science. 1991 Mar 29;251(5001):1616–1618. doi: 10.1126/science.2011743. [DOI] [PubMed] [Google Scholar]
  54. Patterson P. H., Chun L. L. The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3607–3610. doi: 10.1073/pnas.71.9.3607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Patterson P. H., Nawa H. Neuronal differentiation factors/cytokines and synaptic plasticity. Cell. 1993 Jan;72 (Suppl):123–137. doi: 10.1016/s0092-8674(05)80032-7. [DOI] [PubMed] [Google Scholar]
  56. Patterson P. H. The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF? Curr Opin Neurobiol. 1992 Feb;2(1):94–97. doi: 10.1016/0959-4388(92)90169-l. [DOI] [PubMed] [Google Scholar]
  57. Payan D. G., McGillis J. P., Goetzl E. J. Neuroimmunology. Adv Immunol. 1986;39:299–323. doi: 10.1016/s0065-2776(08)60353-3. [DOI] [PubMed] [Google Scholar]
  58. Payan D. G. Substance P: a modulator of neuroendocrine-immune function. Hosp Pract (Off Ed) 1989 Feb 15;24(2):67-73, 76, 78-80. doi: 10.1080/21548331.1989.11703658. [DOI] [PubMed] [Google Scholar]
  59. Rabinovsky E. D., Smith G. M., Browder D. P., Shine H. D., McManaman J. L. Peripheral nerve injury down-regulates CNTF expression in adult rat sciatic nerves. J Neurosci Res. 1992 Jan;31(1):188–192. doi: 10.1002/jnr.490310124. [DOI] [PubMed] [Google Scholar]
  60. Rao M. S., Patterson P. H., Landis S. C. Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors. Development. 1992 Nov;116(3):731–744. doi: 10.1242/dev.116.3.731. [DOI] [PubMed] [Google Scholar]
  61. Rao M. S., Sun Y., Escary J. L., Perreau J., Tresser S., Patterson P. H., Zigmond R. E., Brulet P., Landis S. C. Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons. Neuron. 1993 Dec;11(6):1175–1185. doi: 10.1016/0896-6273(93)90229-k. [DOI] [PubMed] [Google Scholar]
  62. Rohrer H. Cholinergic neuronal differentiation factors: evidence for the presence of both CNTF-like and non-CNTF-like factors in developing rat footpad. Development. 1992 Mar;114(3):689–698. doi: 10.1242/dev.114.3.689. [DOI] [PubMed] [Google Scholar]
  63. Rose T. M., Bruce A. G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8641–8645. doi: 10.1073/pnas.88.19.8641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Schwartz L. B. Mediators of human mast cells and human mast cell subsets. Ann Allergy. 1987 Apr;58(4):226–235. [PubMed] [Google Scholar]
  65. Sendtner M., Kreutzberg G. W., Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature. 1990 May 31;345(6274):440–441. doi: 10.1038/345440a0. [DOI] [PubMed] [Google Scholar]
  66. Sendtner M., Schmalbruch H., Stöckli K. A., Carroll P., Kreutzberg G. W., Thoenen H. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature. 1992 Aug 6;358(6386):502–504. doi: 10.1038/358502a0. [DOI] [PubMed] [Google Scholar]
  67. Sendtner M., Stöckli K. A., Thoenen H. Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration. J Cell Biol. 1992 Jul;118(1):139–148. doi: 10.1083/jcb.118.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Seniuk N., Altares M., Dunn R., Richardson P. M. Decreased synthesis of ciliary neurotrophic factor in degenerating peripheral nerves. Brain Res. 1992 Feb 14;572(1-2):300–302. doi: 10.1016/0006-8993(92)90489-v. [DOI] [PubMed] [Google Scholar]
  69. Serafin W. E., Austen K. F. Mediators of immediate hypersensitivity reactions. N Engl J Med. 1987 Jul 2;317(1):30–34. doi: 10.1056/NEJM198707023170106. [DOI] [PubMed] [Google Scholar]
  70. Shadiack A. M., Hart R. P., Carlson C. D., Jonakait G. M. Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF). J Neurosci. 1993 Jun;13(6):2601–2609. doi: 10.1523/JNEUROSCI.13-06-02601.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Shen M. M., Skoda R. C., Cardiff R. D., Campos-Torres J., Leder P., Ornitz D. M. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 1994 Mar 15;13(6):1375–1385. doi: 10.1002/j.1460-2075.1994.tb06391.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Silverman A. J., Millar R. P., King J. A., Zhuang X., Silver R. Mast cells with gonadotropin-releasing hormone-like immunoreactivity in the brain of doves. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3695–3699. doi: 10.1073/pnas.91.9.3695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Smith G. D., Harmar A. J., McQueen D. S., Seckl J. R. Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat. Neurosci Lett. 1992 Mar 30;137(2):257–260. doi: 10.1016/0304-3940(92)90417-6. [DOI] [PubMed] [Google Scholar]
  74. Stahl N., Boulton T. G., Farruggella T., Ip N. Y., Davis S., Witthuhn B. A., Quelle F. W., Silvennoinen O., Barbieri G., Pellegrini S. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components. Science. 1994 Jan 7;263(5143):92–95. doi: 10.1126/science.8272873. [DOI] [PubMed] [Google Scholar]
  75. Sun Y., Rao M. S., Zigmond R. E., Landis S. C. Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy: the role of cholinergic differentiation factor/leukemia inhibitory factor. J Neurobiol. 1994 Apr;25(4):415–430. doi: 10.1002/neu.480250407. [DOI] [PubMed] [Google Scholar]
  76. Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat Genet. 1994 May;7(1):79–84. doi: 10.1038/ng0594-79. [DOI] [PubMed] [Google Scholar]
  77. Taupin J. L., Morel D., Moreau J. F., Gualde N., Potaux L., Bezian J. H. HILDA/LIF urinary excretion during acute kidney rejection. Transplantation. 1992 Mar;53(3):655–658. doi: 10.1097/00007890-199203000-00031. [DOI] [PubMed] [Google Scholar]
  78. Theoharides T. C. Mast cells: the immune gate to the brain. Life Sci. 1990;46(9):607–617. doi: 10.1016/0024-3205(90)90129-f. [DOI] [PubMed] [Google Scholar]
  79. Unsicker K., Grothe C., Westermann R., Wewetzer K. Cytokines in neural regeneration. Curr Opin Neurobiol. 1992 Oct;2(5):671–678. doi: 10.1016/0959-4388(92)90037-l. [DOI] [PubMed] [Google Scholar]
  80. Waring P. M., Carroll G. J., Kandiah D. A., Buirski G., Metcalf D. Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1993 Jul;36(7):911–915. doi: 10.1002/art.1780360707. [DOI] [PubMed] [Google Scholar]
  81. Waring P., Wycherley K., Cary D., Nicola N., Metcalf D. Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids. J Clin Invest. 1992 Nov;90(5):2031–2037. doi: 10.1172/JCI116083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Weihe E., Millan M. J., Höllt V., Nohr D., Herz A. Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats. Neuroscience. 1989;31(1):77–95. doi: 10.1016/0306-4522(89)90031-6. [DOI] [PubMed] [Google Scholar]

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