Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Sep 27;91(20):9200–9202. doi: 10.1073/pnas.91.20.9200

Protease-activated receptors start a family.

S R Coughlin 1
PMCID: PMC44779  PMID: 7937741

Full text

PDF
9201

Images in this article

9201Image
on p.9201

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bahou W. F., Coller B. S., Potter C. L., Norton K. J., Kutok J. L., Goligorsky M. S. The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation. J Clin Invest. 1993 Apr;91(4):1405–1413. doi: 10.1172/JCI116344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chen J., Ishii M., Wang L., Ishii K., Coughlin S. R. Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J Biol Chem. 1994 Jun 10;269(23):16041–16045. [PubMed] [Google Scholar]
  3. Coller B. S., Ward P., Ceruso M., Scudder L. E., Springer K., Kutok J., Prestwich G. D. Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M. Biochemistry. 1992 Dec 1;31(47):11713–11720. doi: 10.1021/bi00162a007. [DOI] [PubMed] [Google Scholar]
  4. Gerszten R. E., Chen J., Ishii M., Ishii K., Wang L., Nanevicz T., Turck C. W., Vu T. K., Coughlin S. R. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature. 1994 Apr 14;368(6472):648–651. doi: 10.1038/368648a0. [DOI] [PubMed] [Google Scholar]
  5. Hoffman M., Church F. C. Response of blood leukocytes to thrombin receptor peptides. J Leukoc Biol. 1993 Aug;54(2):145–151. doi: 10.1002/jlb.54.2.145. [DOI] [PubMed] [Google Scholar]
  6. Huang R. S., Sorisky A., Church W. R., Simons E. R., Rittenhouse S. E. "Thrombin" receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides. J Biol Chem. 1991 Oct 5;266(28):18435–18438. [PubMed] [Google Scholar]
  7. Hung D. T., Vu T. K., Wheaton V. I., Charo I. F., Nelken N. A., Esmon N., Esmon C. T., Coughlin S. R. "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. J Clin Invest. 1992 Feb;89(2):444–450. doi: 10.1172/JCI115604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hung D. T., Wong Y. H., Vu T. K., Coughlin S. R. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem. 1992 Oct 15;267(29):20831–20834. [PubMed] [Google Scholar]
  9. Ishii K., Hein L., Kobilka B., Coughlin S. R. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J Biol Chem. 1993 May 5;268(13):9780–9786. [PubMed] [Google Scholar]
  10. Liu L. W., Vu T. K., Esmon C. T., Coughlin S. R. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem. 1991 Sep 15;266(26):16977–16980. [PubMed] [Google Scholar]
  11. Mathews I. I., Padmanabhan K. P., Ganesh V., Tulinsky A., Ishii M., Chen J., Turck C. W., Coughlin S. R., Fenton J. W., 2nd Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry. 1994 Mar 22;33(11):3266–3279. doi: 10.1021/bi00177a018. [DOI] [PubMed] [Google Scholar]
  12. McNamara C. A., Sarembock I. J., Gimple L. W., Fenton J. W., 2nd, Coughlin S. R., Owens G. K. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest. 1993 Jan;91(1):94–98. doi: 10.1172/JCI116206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ngaiza J. R., Jaffe E. A. A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells. Biochem Biophys Res Commun. 1991 Sep 30;179(3):1656–1661. doi: 10.1016/0006-291x(91)91765-5. [DOI] [PubMed] [Google Scholar]
  14. Nystedt S., Emilsson K., Wahlestedt C., Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9208–9212. doi: 10.1073/pnas.91.20.9208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Okumura T., Hasitz M., Jamieson G. A. Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surface. J Biol Chem. 1978 May 25;253(10):3435–3443. [PubMed] [Google Scholar]
  16. Rasmussen U. B., Vouret-Craviari V., Jallat S., Schlesinger Y., Pagès G., Pavirani A., Lecocq J. P., Pouysségur J., Van Obberghen-Schilling E. cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett. 1991 Aug 19;288(1-2):123–128. doi: 10.1016/0014-5793(91)81017-3. [DOI] [PubMed] [Google Scholar]
  17. Roldan A. L., Cubellis M. V., Masucci M. T., Behrendt N., Lund L. R., Danø K., Appella E., Blasi F. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J. 1990 Feb;9(2):467–474. doi: 10.1002/j.1460-2075.1990.tb08132.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rydel T. J., Ravichandran K. G., Tulinsky A., Bode W., Huber R., Roitsch C., Fenton J. W., 2nd The structure of a complex of recombinant hirudin and human alpha-thrombin. Science. 1990 Jul 20;249(4966):277–280. doi: 10.1126/science.2374926. [DOI] [PubMed] [Google Scholar]
  19. Sato H., Takino T., Okada Y., Cao J., Shinagawa A., Yamamoto E., Seiki M. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature. 1994 Jul 7;370(6484):61–65. doi: 10.1038/370061a0. [DOI] [PubMed] [Google Scholar]
  20. Scarborough R. M., Naughton M. A., Teng W., Hung D. T., Rose J., Vu T. K., Wheaton V. I., Turck C. W., Coughlin S. R. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem. 1992 Jul 5;267(19):13146–13149. [PubMed] [Google Scholar]
  21. Vassallo R. R., Jr, Kieber-Emmons T., Cichowski K., Brass L. F. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem. 1992 Mar 25;267(9):6081–6085. [PubMed] [Google Scholar]
  22. Vu T. K., Hung D. T., Wheaton V. I., Coughlin S. R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22;64(6):1057–1068. doi: 10.1016/0092-8674(91)90261-v. [DOI] [PubMed] [Google Scholar]
  23. Vu T. K., Wheaton V. I., Hung D. T., Charo I., Coughlin S. R. Domains specifying thrombin-receptor interaction. Nature. 1991 Oct 17;353(6345):674–677. doi: 10.1038/353674a0. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES