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. 1994 Dec 20;91(26):12448–12452. doi: 10.1073/pnas.91.26.12448

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.

L Cohen 1, R Mohr 1, Y Y Chen 1, M Huang 1, R Kato 1, D Dorin 1, F Tamanoi 1, A Goga 1, D Afar 1, N Rosenberg 1, et al.
PMCID: PMC45455  PMID: 7809057

Abstract

We report the characterization of a member of the ras gene family that is overexpressed in cells transformed by abl tyrosine kinase oncogenes. The gene, named kir (for kinase-inducible ras-like), is induced at the transcriptional level. kir mRNA has a rapid turnover and encodes a protein of 33 kDa with guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. kir was cloned by differential screening of genes present in fully malignant versus growth factor-independent cell lines expressing wild-type or mutant forms of BCR/ABL. BCR/ABL and v-Abl induce transcription of the kir gene via specific signaling pathway(s), but kir overexpression alone is not sufficient to mediate transformation.

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