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. 1984 Jan;39(1):14–18. doi: 10.1136/thx.39.1.14

High prevalence of familial sarcoidosis in an Irish population.

N J Brennan, P Crean, J P Long, M X Fitzgerald
PMCID: PMC459714  PMID: 6695348

Abstract

Previous studies in the Republic of Ireland have demonstrated a high national prevalence of sarcoidosis. Observations in our sarcoid clinic suggested a high prevalence of the disease among siblings and prompted a survey to quantify this phenomenon. The study group comprised 114 index patients with biopsy proved sarcoidosis and a total sibling pool of 534 individuals. Eleven of the index patients (9.6%) were found to have at least one sibling with sarcoidosis. Of the 13 siblings thus identified, eight had biopsy proof of the disease, while the remaining five showed highly suggestive clinical and radiological evidence of sarcoidosis. There was no significant difference in the mode of presentation between the sibling pairs or between familial and non-familial cases and there was an equal distribution of like sex and unlike sex pairs. In only two instances was the temporal profile of onset of the disease suggestive of intrafamilial spread of a transmissible agent. The high prevalence of sarcoidosis among siblings reported here (2.4%) suggests that genetic factors significantly predispose to the development of sarcoidosis and that family members of affected patients should be screened for this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer H. J., Löfgren S. International study of pulmonary sarcoidosis in mass chest radiography. Acta Med Scand Suppl. 1964;425:103–105. doi: 10.1111/j.0954-6820.1964.tb05712.x. [DOI] [PubMed] [Google Scholar]
  2. Brewerton D. A., Cockburn C., James D. C., James D. G., Neville E. HLA antigens in sarcoidosis. Clin Exp Immunol. 1977 Feb;27(2):227–229. [PMC free article] [PubMed] [Google Scholar]
  3. Davies B. H. Infectivity of tuberculosis. Thorax. 1980 Jul;35(7):481–482. doi: 10.1136/thx.35.7.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eisenberg H., Terasaki P. I., Sharma O. P., Mickey M. R., Jr HLA association studies in black sarcoidosis patients. Tissue Antigens. 1978 May;11(5):484–486. doi: 10.1111/j.1399-0039.1978.tb01289.x. [DOI] [PubMed] [Google Scholar]
  5. Hall G., Naish P., Sharma O. P., Doe W., James D. G. The epidemiology of sarcoidosis. Postgrad Med J. 1969 Apr;45(522):241–250. doi: 10.1136/pgmj.45.522.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harrison P. V., Ive F. A. Sarcoidosis in husband and wife. N Y State J Med. 1978 Nov;78(13):2130–2130. [PubMed] [Google Scholar]
  7. Headings V. E., Weston D., Young R. C., Jr, hackney R. L., Jr Familial sarcoidosis with multiple occurrences in eleven families: a possible mechanism of inheritance. Ann N Y Acad Sci. 1976;278:377–385. doi: 10.1111/j.1749-6632.1976.tb47049.x. [DOI] [PubMed] [Google Scholar]
  8. Hedfors E., Möller E. HL-A antigens in sarcoidosis. Tissue Antigens. 1973;3(2):95–98. doi: 10.1111/j.1399-0039.1973.tb00983.x. [DOI] [PubMed] [Google Scholar]
  9. James D. G., Neville E., Piyasena K. H., Walker A. N., Hamlyn A. N. Possible genetic influences in familial sarcoidosis. Postgrad Med J. 1974 Nov;50(589):664–670. doi: 10.1136/pgmj.50.589.664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kostina Z. I., Volkova K. I. Semeinyi sarkoidoz. Klin Med (Mosk) 1978 Apr;56(4):129–131. [PubMed] [Google Scholar]
  11. Kueppers F., Mueller-Eckhardt C., Heinrich D., Schwab B., Brackertz D. HL-A antigens of patients with sarcoidosis. Tissue Antigens. 1974;4(1):56–58. doi: 10.1111/j.1399-0039.1974.tb00225.x. [DOI] [PubMed] [Google Scholar]
  12. Logan J. Prevalence of sarcoidosis in the Irish Republic. Acta Med Scand Suppl. 1964;425:126–126. doi: 10.1111/j.0954-6820.1964.tb05720.x. [DOI] [PubMed] [Google Scholar]
  13. McIntyre J. A., McKee K. T., Loadholt C. B., Mercurio S., Lin I. Increased HLA-B7 antigen frequency in South Carolina blacks in association with sarcoidosis. Transplant Proc. 1977 Mar;9(1 Suppl 1):173–176. [PubMed] [Google Scholar]
  14. Möller E., Hedfors E., Wiman L. G. HL-A genotypes and MLR in familial sarcoidosis. Tissue Antigens. 1974;4(4):299–305. doi: 10.1111/j.1399-0039.1974.tb00256.x. [DOI] [PubMed] [Google Scholar]
  15. Persson I., Ryder L. P., Nielsen L. S., Svejgaard A. The HL-A7 histocompatibility antigen in sarcoidosis in relation to tuberculin sensitivity. Tissue Antigens. 1975 Jul;6(1):50–53. doi: 10.1111/j.1399-0039.1975.tb00612.x. [DOI] [PubMed] [Google Scholar]
  16. Renner R. R., Lahiri M., Bragoli A. J. Sarcoidosis in husband and wife. N Y State J Med. 1977 Jan;77(1):118–119. [PubMed] [Google Scholar]
  17. Sharma O. P., Johnson C. S., Balchum O. J. Familial sarcoidosis. Report of four siblings with acute sarcoidosis. Am Rev Respir Dis. 1971 Aug;104(2):255–257. doi: 10.1164/arrd.1971.104.2.255. [DOI] [PubMed] [Google Scholar]
  18. Sharma O. P., Neville E., Walker A. N., James D. G. Familial sarcoidosis: a possible genetic influence. Ann N Y Acad Sci. 1976;278:386–400. doi: 10.1111/j.1749-6632.1976.tb47050.x. [DOI] [PubMed] [Google Scholar]
  19. Smith M. J., Turton C. W., Mitchell D. N., Turner-Warwick M., Morris L. M., Lawler S. D. Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax. 1981 Apr;36(4):296–298. doi: 10.1136/thx.36.4.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stewart I. C., Davidson N. M. Clustering of sarcoidosis. Thorax. 1982 May;37(5):398–399. doi: 10.1136/thx.37.5.398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Turiaf J., Battesti J. P., Jeanjean Y., Fourestier V. Sarcoïdose familiale. 26 cas dans 12 familles. Nouv Presse Med. 1978 Mar 18;7(11):913–915. [PubMed] [Google Scholar]

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