Abstract
We report results of HLA-A, B, C, and DR typing in groups of white Caucasians of English descent and black West Indians of African descent with sarcoidosis. In the English patients we found a significantly increased frequency of Cw7, which was not found in the West Indian patients. Our results also suggest that DR3 and, in particular, inheritance of the B8/Cw7/DR3 haplotype is associated with good prognosis in English patients with sarcoidosis. There was no association between any HLA antigen and prognosis in the West Indian patients in this study.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bergholtz B. O., Thorsby E. HLA-D restriction of the macrophage-dependent response of immune human T lymphocytes to PPD in vitro: inhibition by anti-HLA-DR antisera. Scand J Immunol. 1978;8(1):63–73. doi: 10.1111/j.1365-3083.1978.tb00496.x. [DOI] [PubMed] [Google Scholar]
- Farid N. R., Bear J. C. The human major histocompatibility complex and endocrine disease. Endocr Rev. 1981 Winter;2(1):50–86. doi: 10.1210/edrv-2-1-50. [DOI] [PubMed] [Google Scholar]
- Hedfors E., Möller E. HL-A antigens in sarcoidosis. Tissue Antigens. 1973;3(2):95–98. doi: 10.1111/j.1399-0039.1973.tb00983.x. [DOI] [PubMed] [Google Scholar]
- Lawley T. J., Hall R. P., Fauci A. S., Katz S. I., Hamburger M. I., Frank M. M. Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects. N Engl J Med. 1981 Jan 22;304(4):185–192. doi: 10.1056/NEJM198101223040401. [DOI] [PubMed] [Google Scholar]
- Olenchock S. A., Heise E. R., Marx J. J., Jr, Mentnech M. S., Mull J. C., Spurgeon D. E., Hancock J. S., Elliott J. A., Pearson D. J., Price C. D. HLA-B8 in sarcoidosis. Ann Allergy. 1981 Sep;47(3):151–153. [PubMed] [Google Scholar]
- Smith M. J., Turton C. W., Mitchell D. N., Turner-Warwick M., Morris L. M., Lawler S. D. Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax. 1981 Apr;36(4):296–298. doi: 10.1136/thx.36.4.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spagnuolo P. J., Ellner J. J., Bouknight R., Tomford J. W., Kleinhenz M. E., Edmonds K. L. Interrelationships of immunoregulatory cells and serum factors in sarcoidosis. J Immunol. 1980 Sep;125(3):1071–1077. [PubMed] [Google Scholar]
- Woodrow J. C., Nichol F. E., Zaphiropoulos G. DR antigens and rheumatoid arthritis: a study of two populations. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1287–1288. doi: 10.1136/bmj.283.6302.1287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van Rood J. J., van Leeuwen A., Ploem J. S. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Nature. 1976 Aug 26;262(5571):795–797. doi: 10.1038/262795a0. [DOI] [PubMed] [Google Scholar]