Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1984 Mar;39(3):185–191. doi: 10.1136/thx.39.3.185

Cutaneous vasculitis and immune complexes in severe bronchiectasis.

A M Hilton, P S Hasleton, A Bradlow, B C Leahy, K M Cooper, M Moore
PMCID: PMC459759  PMID: 6710426

Abstract

Four patients with severe bronchiectasis (chronic bronchial suppuration) are described who developed cutaneous lesions associated with exacerbations of their respiratory disease. The skin abnormalities consisted of purpuric lesions in three patients and an erythematous vasculitis in one. Circulating immune complexes were present in all patients and in three skin biopsy specimens showed deposition of C3, IgG, and IgA in dermal blood vessels. Haemophilus influenzae had been isolated from the sputum of all four patients and in two patients was present at the time the cutaneous lesions appeared. It is suggested that local immune complex deposition was responsible for the skin lesions which occurred during acute exacerbations of bronchiectasis.

Full text

PDF
187

Images in this article

186Image
on p.186
190Image
on p.190
190Image
on p.190

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brentjens J. R., O'Connell D. W., Pawlowski I. B., Hsu K. C., Andres G. A. Experimental immune complex disease of the lung. The pathogenesis of a laboratory model resembling certain human interstitial lung diseases. J Exp Med. 1974 Jul 1;140(1):105–125. doi: 10.1084/jem.140.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Butland R. J., Cole P., Citron K. M., Turner-Warwick M. Chronic bronchial suppuration and inflammatory bowel disease. Q J Med. 1981;50(197):63–75. [PubMed] [Google Scholar]
  3. Cairns S. A., Mallick N. P., Lawler W., Williams G. Squamous cell carcinoma of bronchus presenting with Henoch-Schönlein purpura. Br Med J. 1978 Aug 12;2(6135):474–475. doi: 10.1136/bmj.2.6135.474-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper K. M., Moore M. Heterogeneity of circulating immune complexes in chronic lung diseases. J Clin Lab Immunol. 1982 Apr;7(3):155–161. [PubMed] [Google Scholar]
  5. Cooper K. M., Moore M., Hilton A. M. C1q binding activity in the sera of patients with chronic lung diseases. Clin Exp Immunol. 1981 Jul;45(1):18–28. [PMC free article] [PubMed] [Google Scholar]
  6. Cream J. J. Clinical and immunological aspects of cutaneous vasculitis. Q J Med. 1976 Apr;45(178):255–276. [PubMed] [Google Scholar]
  7. Dreisin R. B., Schwarz M. I., Theofilopoulos A. N., Stanford R. E. Circulating immune complexes in the idiopathic interstitial pneumonias. N Engl J Med. 1978 Feb 16;298(7):353–357. doi: 10.1056/NEJM197802162980701. [DOI] [PubMed] [Google Scholar]
  8. Dufourcq J., Clin B., Lemanceau B. NMR Study of ganglion-blocking and curare-like dimethoniums conformation in aqueous solutions. FEBS Lett. 1972 May 1;22(2):205–209. doi: 10.1016/0014-5793(72)80046-2. [DOI] [PubMed] [Google Scholar]
  9. Haslam P. L., Thompson B., Mohammed I., Townsend P. J., Hodson M. E., Holborow E. J., Turner-Warwick M. Circulating immune complexes in patients with cryptogenic fibrosing alveolitis. Clin Exp Immunol. 1979 Sep;37(3):381–390. [PMC free article] [PubMed] [Google Scholar]
  10. Hay F. C., Nineham L. J., Roitt I. M. Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase C1q. Clin Exp Immunol. 1976 Jun;24(3):396–400. [PMC free article] [PubMed] [Google Scholar]
  11. Hilton A. M., Doyle L. Immunological abnormalities in bronchiectasis with chronic bronchial suppuration. Br J Dis Chest. 1978 Jul;72(3):207–216. doi: 10.1016/0007-0971(78)90043-8. [DOI] [PubMed] [Google Scholar]
  12. Hilton A. M., Moore M., Howat J. M. Detection of circulating anticomplementary factors in chronic lung diseases. Clin Exp Immunol. 1978 Feb;31(2):237–243. [PMC free article] [PubMed] [Google Scholar]
  13. Hobbs J. R., Turner-Warwick M. Assay of circulating immunoglobulins in patients with fibrosing alveolitis. Clin Exp Immunol. 1967 Nov;2(6):645–652. [PMC free article] [PubMed] [Google Scholar]
  14. Mathieu J. P., Stack B. H., Dick W. C., Buchanan W. W. Pulmonary infection and rheumatoid arthritis. Br J Dis Chest. 1978 Jan;72(1):57–61. doi: 10.1016/0007-0971(78)90007-4. [DOI] [PubMed] [Google Scholar]
  15. Samayoa E. A., McDuffie F. C., Nelson A. M., Go V. L., Luthra H. S., Brumfield H. W. Immunoglobulin complexes in sera of patients with malignancy. Int J Cancer. 1977 Jan;19(1):12–17. doi: 10.1002/ijc.2910190103. [DOI] [PubMed] [Google Scholar]
  16. Scherzer H., Ward P. A. Lung and dermal vascular injury produced by preformed immune complexes. Am Rev Respir Dis. 1978 Mar;117(3):551–557. doi: 10.1164/arrd.1978.117.3.551. [DOI] [PubMed] [Google Scholar]
  17. Schroeter A. L., Copeman P. W., Jordon R. E., Sams W. M., Jr, Winkelmann R. K. Immunofluorescence of cutaneous vasculitis associated with systemic disease. Arch Dermatol. 1971 Sep;104(3):254–259. [PubMed] [Google Scholar]
  18. Theofilopoulos A. N. Immune complexes in cancer. N Engl J Med. 1982 Nov 4;307(19):1208–1210. doi: 10.1056/NEJM198211043071910. [DOI] [PubMed] [Google Scholar]
  19. Turner-Warwick M., Haslam P. Antibodies in some chronic fibrosing lung diseases. I. Non organ-specific autoantibodies. Clin Allergy. 1971 Mar;1(1):83–95. doi: 10.1111/j.1365-2222.1971.tb02450.x. [DOI] [PubMed] [Google Scholar]
  20. Turner-Warwick M., Haslam P., Weeks J. Antibodies in some chronic fibrosing lung diseases. II. Immunofluorescent studies. Clin Allergy. 1971 Jun;1(2):209–219. doi: 10.1111/j.1365-2222.1971.tb03020.x. [DOI] [PubMed] [Google Scholar]
  21. Volanakis J. E., Stroud R. M. Rabbit C1q: purification, functional and structural studies. J Immunol Methods. 1972 Nov;2(1):25–34. doi: 10.1016/0022-1759(72)90014-2. [DOI] [PubMed] [Google Scholar]
  22. Walker W. C. Pulmonary infections and rheumatoid arthritis. Q J Med. 1967 Apr;36(142):239–251. [PubMed] [Google Scholar]
  23. Zubler R. H., Lange G., Lambert P. H., Miescher P. A. Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol. 1976 Jan;116(1):232–235. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES