Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1984 Nov;39(11):862–867. doi: 10.1136/thx.39.11.862

Management of pulmonary aspergilloma in the presence of active tuberculosis.

A O Adeyemo, E O Odelowo, D I Makanjuola
PMCID: PMC459938  PMID: 6390774

Abstract

Eleven cases of pulmonary aspergilloma complicating active cavitating pulmonary tuberculosis are reviewed. Nine of the 10 patients who had combined medical (antituberculosis drugs) and surgical treatment were cured of their disease; one patient, who had bilateral multiple aspergillomas, died from massive haemoptysis after resection of one of the affected lobes. The only medically treated patient who refused surgery had fatal haemoptysis at home. Pulmonary resection is recommended for patients who are fit for operation whenever the diagnosis of aspergilloma is made because most published reports indicate that only a few patients benefit from drug treatment alone.

Full text

PDF
865

Images in this article

863Image
on p.863
864Image
on p.864
864Image
on p.864
864Image
on p.864
864Image
on p.864

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRUCE R. A. A case of pulmonary aspergillosis. Tubercle. 1957 Jun;38(3):203–209. doi: 10.1016/s0041-3879(57)80088-9. [DOI] [PubMed] [Google Scholar]
  2. Benjamin J. J., Koerner S. K., Grunwald R. P., Fell S. C. Bilateral pulmonary resections for aspergillomas. Chest. 1971 Jul;60(1):107–109. doi: 10.1378/chest.60.1.107. [DOI] [PubMed] [Google Scholar]
  3. Bindschadler D. D., Bennett J. E. A pharmacologic guide to the clinical use of amphotericin B. J Infect Dis. 1969 Oct;120(4):427–436. doi: 10.1093/infdis/120.4.427. [DOI] [PubMed] [Google Scholar]
  4. CAMPBELL M. J., CLAYTON Y. M. BRONCHOPULMONARY ASPERGILLOSIS. A CORRELATION OF THE CLINICAL AND LABORATORY FINDINGS IN 272 PATIENTS INVESTIGATED FOR BRONCHOPULMONARY ASPERGILLOSIS. Am Rev Respir Dis. 1964 Feb;89:186–196. doi: 10.1164/arrd.1964.89.2.186. [DOI] [PubMed] [Google Scholar]
  5. Cohen R., Roth F. J., Delgado E., Ahearn D. G., Kalser M. H. Fungal flora of the normal human small and large intestine. N Engl J Med. 1969 Mar 20;280(12):638–641. doi: 10.1056/NEJM196903202801204. [DOI] [PubMed] [Google Scholar]
  6. Davies D., Somner A. R. Pulmonary aspergillomas treated with corticosteroids. Thorax. 1972 Mar;27(2):156–162. doi: 10.1136/thx.27.2.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dieter R. A., Jr, Pifarré R., Neville W. E., Magno M., Jasuja M. Empyema treated with neomycin irrigation and closed-chest drainage. J Thorac Cardiovasc Surg. 1970 Apr;59(4):496–500. [PubMed] [Google Scholar]
  8. English M. P., Henderson A. H. Significance and interpretation of laboratory tests in pulmonary aspergillosis. J Clin Pathol. 1967 Nov;20(6):832–834. doi: 10.1136/jcp.20.6.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Faulkner S. L., Vernon R., Brown P. P., Fisher R. D., Bender H. W., Jr Hemoptysis and pulmonary aspergilloma: operative versus nonoperative treatment. Ann Thorac Surg. 1978 May;25(5):389–392. doi: 10.1016/s0003-4975(10)63570-9. [DOI] [PubMed] [Google Scholar]
  10. Henderson A. H., Pearson J. E. Treatment of bronchopulmonary aspergillosis with observations on the use of natamycin. Thorax. 1968 Sep;23(5):519–523. doi: 10.1136/thx.23.5.519. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Irwin A. Radiology of the aspergilloma. Clin Radiol. 1967 Oct;18(4):432–438. doi: 10.1016/s0009-9260(67)80055-2. [DOI] [PubMed] [Google Scholar]
  12. Israel H. L., Ostrow A. Sarcoidosis and aspergilloma. Am J Med. 1969 Aug;47(2):243–250. doi: 10.1016/0002-9343(69)90150-8. [DOI] [PubMed] [Google Scholar]
  13. Jewkes J., Kay P. H., Paneth M., Citron K. M. Pulmonary aspergilloma: analysis of prognosis in relation to haemoptysis and survey of treatment. Thorax. 1983 Aug;38(8):572–578. doi: 10.1136/thx.38.8.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Karas A., Hankins J. R., Attar S., Miller J. E., McLaughlin J. S. Pulmonary aspergillosis: an analysis of 41 patients. Ann Thorac Surg. 1976 Jul;22(1):1–7. doi: 10.1016/s0003-4975(10)63943-4. [DOI] [PubMed] [Google Scholar]
  15. Kilman J. W., Ahn C., Andrews N. C., Klassen K. Surgery for pulmonary aspergillosis. J Thorac Cardiovasc Surg. 1969 May;57(5):642–647. [PubMed] [Google Scholar]
  16. MACPHERSON P. PULMONARY ASPERGILLOSIS IN ARGYLL. Br J Dis Chest. 1965 Jul;59:148–157. doi: 10.1016/s0007-0971(65)80005-5. [DOI] [PubMed] [Google Scholar]
  17. Mills S. A., Wolfe W. G. Opportunistic infections of the lung. Surg Clin North Am. 1980 Aug;60(4):913–930. doi: 10.1016/s0039-6109(16)42191-2. [DOI] [PubMed] [Google Scholar]
  18. PECORA D. V., TOLL M. W. Pulmonary resection for localized aspergillosis. N Engl J Med. 1960 Oct 20;263:785–787. doi: 10.1056/NEJM196010202631605. [DOI] [PubMed] [Google Scholar]
  19. PLIHAL V., JEDLICKOVA Z., VIKLICKY J., TOMANEK A. MULTIPLE BILATERAL PULMONARY ASPERGILLOMATA. Thorax. 1964 Mar;19:104–111. doi: 10.1136/thx.19.2.104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Parker J. D., Sarosi G. A., Doto I. L., Tosh F. E. Pulmonary aspergillosis in sanatoriums in the south central United States. A national communicable disease center cooperative mycoses study. Am Rev Respir Dis. 1970 Apr;101(4):551–557. doi: 10.1164/arrd.1970.101.4.551. [DOI] [PubMed] [Google Scholar]
  21. RAMIREZ J. PULMONARY ASPERGILLOMA: ENDOBRONCHIAL TREATMENT. N Engl J Med. 1964 Dec 17;271:1281–1285. doi: 10.1056/NEJM196412172712502. [DOI] [PubMed] [Google Scholar]
  22. Rao R. S., Curzon P. G., Muers M. F., Watson D. A. Cavernoscopic evacuation of aspergilloma: an alternative method of palliation for haemoptysis in high risk patients. Thorax. 1984 May;39(5):394–396. doi: 10.1136/thx.39.5.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rémy J., Arnaud A., Fardou H., Giraud R., Voisin C. Treatment of hemoptysis by embolization of bronchial arteries. Radiology. 1977 Jan;122(1):33–37. doi: 10.1148/122.1.33. [DOI] [PubMed] [Google Scholar]
  24. Shneerson J. M., Emerson P. A., Phillips R. H. Radiotherapy for massive haemoptysis from an aspergilloma. Thorax. 1980 Dec;35(12):953–954. doi: 10.1136/thx.35.12.953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Solit R. W., McKeown J. J., Jr, Smullens S., Fraimow W. The surgical implications of intracavitary mycetomas (fungus balls). J Thorac Cardiovasc Surg. 1971 Sep;62(3):411–422. [PubMed] [Google Scholar]
  26. Strutz G. M., Rossi N. P., Ehrenhaft J. L. Pulmonary aspergillosis. J Thorac Cardiovasc Surg. 1972 Dec;64(6):963–968. [PubMed] [Google Scholar]
  27. Takaro T. Mycotic infections of interest to thoracic surgeons. Ann Thorac Surg. 1967 Jan;3(1):71–93. doi: 10.1016/s0003-4975(10)66692-1. [DOI] [PubMed] [Google Scholar]
  28. VILLAR T. G., PIMENTEL J. C., FREITAS E COSTA M. The tumour-like forms of aspergillosis of the lung (pulmonary aspergilloma). A report of five new cases and a review of the Portuguese literature. Thorax. 1962 Mar;17:22–38. doi: 10.1136/thx.17.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Varkey B., Rose H. D. Pulmonary aspergilloma. A rational approach to treatment. Am J Med. 1976 Nov;61(5):626–631. doi: 10.1016/0002-9343(76)90140-6. [DOI] [PubMed] [Google Scholar]
  30. Zimmerman R. A., Miller W. T. Pulmonary aspergillosis. Am J Roentgenol Radium Ther Nucl Med. 1970 Jul;109(3):505–517. doi: 10.2214/ajr.109.3.505. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES