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. 1985 Feb;40(2):85–90. doi: 10.1136/thx.40.2.85

Neurone specific enolase: a useful diagnostic serum marker for small cell carcinoma of the lung.

T Esscher, L Steinholtz, J Bergh, E Nöu, K Nilsson, S Påhlman
PMCID: PMC459994  PMID: 2983452

Abstract

Among lung cancers small cell carcinoma is the most sensitive to chemotherapy and radiation. This has emphasised the importance of an accurate diagnosis of this cell type, and the present study examined the use of serum neurone specific enolase (NSE) as a diagnostic marker for small cell carcinoma. NSE was measured in pretreatment sera from 103 patients with small cell carcinoma and in sera from relevant controls, including patients with other lung cancers, non-malignant lung diseases, and healthy adults. Serum NSE concentration was raised (greater than 25 ng/ml) in 72% of patients with small cell carcinoma. Ninety one per cent of patients with extensive disease and 50% of patients with limited disease were serum NSE positive. Patients with extensive disease in general had higher serum NSE concentrations than patients with limited disease. No definite difference in serum NSE positivity could be shown between oat cell and intermediate cell subtypes. Out of 51 patients with other lung cancers, four (8%) had a raised serum concentration, whereas all patients with non-malignant diseases and healthy individuals had normal serum NSE concentrations. Serum NSE determination seems to be a valuable tool for the diagnosis of small cell carcinoma.

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Selected References

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  1. Ariyoshi Y., Kato K., Ishiguro Y., Ota K., Sato T., Suchi T. Evaluation of serum neuron-specific enolase as a tumor marker for carcinoma of the lung. Gan. 1983 Apr;74(2):219–225. [PubMed] [Google Scholar]
  2. Carney D. N., Broder L., Edelstein M., Gazdar A. F., Hansen M., Havemann K., Matthews M. J., Sorenson G. D., Videløv L. Experimental studies of the biology of human small cell lung cancer. Cancer Treat Rep. 1983 Jan;67(1):27–35. [PubMed] [Google Scholar]
  3. Carney D. N., Marangos P. J., Ihde D. C., Bunn P. A., Jr, Cohen M. H., Minna J. D., Gazdar A. F. Serum neuron-specific enolase: a marker for disease extent and response to therapy of small-cell lung cancer. Lancet. 1982 Mar 13;1(8272):583–585. doi: 10.1016/s0140-6736(82)91748-2. [DOI] [PubMed] [Google Scholar]
  4. Fletcher L., Rider C. C., Taylor C. B. Enolase isoenzymes. III. Chromatographic and immunological characteristics of rat brain enolase. Biochim Biophys Acta. 1976 Nov 8;452(1):245–252. doi: 10.1016/0005-2744(76)90077-2. [DOI] [PubMed] [Google Scholar]
  5. Hardy J. D., Ewing H. P., Neely W. A., Stauss H. K., Vance R. B. Lung carcinoma: survey of 2286 cases with emphasis on small cell type. Ann Surg. 1981 May;193(5):539–548. doi: 10.1097/00000658-198105000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ishiguro Y., Kato K., Shimizu A., Ito T., Nagaya M. High levels of immunoreactive nervous system-specific enolase in sera of patients with neuroblastoma. Clin Chim Acta. 1982 May 20;121(2):173–180. doi: 10.1016/0009-8981(82)90056-0. [DOI] [PubMed] [Google Scholar]
  7. Marangos P. J., Zis A. P., Clark R. L., Goodwin F. K. Neuronal, non-neuronal and hybrid forms of enolase in brain: structural, immunological and functional comparisons. Brain Res. 1978 Jul 7;150(1):117–133. doi: 10.1016/0006-8993(78)90657-1. [DOI] [PubMed] [Google Scholar]
  8. Marangos P. J., Zomzely-Neurath C., Goodwin F. K. Structural and immunological properties of neuron specific protein (NSP) from rat, cat and human brain: comparison to bovine 14-3-2. J Neurochem. 1977 May;28(5):1097–1107. doi: 10.1111/j.1471-4159.1977.tb10674.x. [DOI] [PubMed] [Google Scholar]
  9. Odelstad L., Påhlman S., Läckgren G., Larsson E., Grotte G., Nilsson K. Neuron specific enolase: a marker for differential diagnosis of neuroblastoma and Wilms' tumor. J Pediatr Surg. 1982 Aug;17(4):381–385. doi: 10.1016/s0022-3468(82)80494-6. [DOI] [PubMed] [Google Scholar]
  10. Prinz R. A., Marangos P. J. Serum neuron-specific enolase: a serum marker for nonfunctioning pancreatic islet cell carcinoma. Am J Surg. 1983 Jan;145(1):77–81. doi: 10.1016/0002-9610(83)90170-8. [DOI] [PubMed] [Google Scholar]
  11. Påhlman S., Esscher T., Bergh J., Steinholtz L., Nöu E., Nilsson K. Neuron-specific enolase as a marker for neuroblastoma and small-cell carcinoma of the lung. Tumour Biol. 1984;5(2):119–126. [PubMed] [Google Scholar]
  12. Påhlman S., Esscher T., Bergvall P., Odelstad L. Purification and characterization of human neuron-specific enolase: radioimmunoassay development. Tumour Biol. 1984;5(2):127–139. [PubMed] [Google Scholar]
  13. Rider C. C., Taylor C. B. Evidence for a new form of enolase in rat brain. Biochem Biophys Res Commun. 1975 Sep 16;66(2):814–820. doi: 10.1016/0006-291x(75)90582-3. [DOI] [PubMed] [Google Scholar]

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