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. 1986 Jan;41(1):17–24. doi: 10.1136/thx.41.1.17

Effect of cigarette smoking, pulmonary inflammation, and lung disease on concentrations of carcinoembryonic antigen in serum and secretions.

R A Stockley, J Shaw, A G Whitfield, T P Whitehead, C A Clarke, D Burnett
PMCID: PMC460246  PMID: 3704962

Abstract

A specific radioimmunoassay for carcinoembryonic antigen was used to investigate aspects of its measurement in lung disease. The results confirm that serum carcinoembryonic antigen concentrations are higher in healthy smokers and patients with chronic obstructive bronchitis than in healthy non smokers (p less than 0.01). Corticosteroid treatment reduced the concentration in nine patients with bronchitis (p less than 0.05). Other inflammatory lung diseases (bronchiectasis, pneumonia, fibrosing alveolitis) are not associated with a raised serum carcinoembryonic antigen concentration. The sputum concentrations were about 100 times those found in serum and there was a positive correlation (r = 0.611 2p less than 0.01) between the concentrations in sputum and serum in patients with bronchitis. No preferential rise in sputum concentration was found in current smokers or patients with lung carcinoma (n = 16). A higher ratio of carcinoembryonic antigen to albumin concentration (p less than 0.05) was, however, found in lavage fluid obtained from the tumour site than in fluid from "normal" lung in the same patients, suggesting an increase in carcinoembryonic antigen secretion in the vicinity of the tumour. Despite this "local" effect the sputum concentration does not, however, appear to be a useful marker of lung carcinoma and the measurement could not be used as a screening test.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Booth S. N., Lakin G., Dykes P. W., Burnett D., Bradwell A. R. Cancer-associated proteins in effusion fluids. J Clin Pathol. 1977 Jun;30(6):537–540. doi: 10.1136/jcp.30.6.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burnett D., Booth S. N., Bradwell A. R. Fibrin/fibrinogen degradation products in pleural exudate. Lancet. 1976 Sep 4;1(7984):523–523. doi: 10.1016/s0140-6736(76)90821-7. [DOI] [PubMed] [Google Scholar]
  3. Clarke C., Hine K. R., Dykes P. W., Whitehead T. P., Whitfield A. G. Carcinoembryonic antigen and smoking. J R Coll Physicians Lond. 1980 Oct;14(4):227–228. [PMC free article] [PubMed] [Google Scholar]
  4. Coligan J. E., Henkart P. A., Todd C. W., Terry W. D. Heterogeneity of the carcinoembryonic antigen. Immunochemistry. 1973 Sep;10(9):591–599. doi: 10.1016/0019-2791(73)90160-2. [DOI] [PubMed] [Google Scholar]
  5. Coligan J. E., Lautenschleger J. T., Egan M. L., Todd C. W. Isolation and characterization of carcinoembryonic antigen. Immunochemistry. 1972 Apr;9(4):377–386. doi: 10.1016/0019-2791(72)90308-4. [DOI] [PubMed] [Google Scholar]
  6. Egan M. L., Lautenschleger J. T., Coligan J. E., Todd C. W. Radioimmune assay of carcinoembryonic antigen. Immunochemistry. 1972 Mar;9(3):289–299. doi: 10.1016/0019-2791(72)90093-6. [DOI] [PubMed] [Google Scholar]
  7. Hine K. R., Booth S. N., Leonard J. C., Dykes P. W. Carcinoembryonic antigen concentrations in undiagnosed patients. Lancet. 1978 Dec 23;2(8104-5):1337–1340. doi: 10.1016/s0140-6736(78)91975-x. [DOI] [PubMed] [Google Scholar]
  8. Jones J. G., Minty B. D., Lawler P., Hulands G., Crawley J. C., Veall N. Increased alveolar epithelial permeability in cigarette smokers. Lancet. 1980 Jan 12;1(8159):66–68. doi: 10.1016/s0140-6736(80)90493-6. [DOI] [PubMed] [Google Scholar]
  9. Laurence D. J., Stevens U., Bettelheim R., Darcy D., Leese C., Turberville C., Alexander P., Johns E. W., Neville A. M. Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma. Br Med J. 1972 Sep 9;3(5827):605–609. doi: 10.1136/bmj.3.5827.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lemarie C., Lavandier M., Renoux M., Renoux G. Carcinoembryonic antigen in bronchoalveolar lavage fluid. N Engl J Med. 1980 Sep 4;303(10):586–587. [PubMed] [Google Scholar]
  11. Merrill W. W., Goodman M., Matthay R. A., Naegel G. P., Vandevoorde J. P., Myl A. D., Reynolds H. Y. Quantitation of carcinoembryonic antigen in the lung lining fluid of normal smokers and nonsmokers. Am Rev Respir Dis. 1981 Jan;123(1):29–31. doi: 10.1164/arrd.1981.123.1.29. [DOI] [PubMed] [Google Scholar]
  12. Pusztaszeri G., Mach J. P. Carcinoembryonic antigen (CEA) in non digestive cancerous and normal tissues. Immunochemistry. 1973 Mar;10(3):197–204. doi: 10.1016/0019-2791(73)90008-6. [DOI] [PubMed] [Google Scholar]
  13. Rittgers R. A., Loewenstein M. S., Feinerman A. E., Kupchik H. Z., Marcel B. R., Koff R. S., Zamcheck N. Carcinoembryonic antigen levels in benign and malignant pleural effusions. Ann Intern Med. 1978 May;88(5):631–634. doi: 10.7326/0003-4819-88-5-631. [DOI] [PubMed] [Google Scholar]
  14. Stevens D. P., Mackay I. R., Cullen K. J. Carcinoembryonic antigen in an unselected elderly population: a four year follow up. Br J Cancer. 1975 Aug;32(2):147–151. doi: 10.1038/bjc.1975.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Stevens D. P., Mackay I. R. Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet. 1973 Dec 1;2(7840):1238–1239. doi: 10.1016/s0140-6736(73)90975-6. [DOI] [PubMed] [Google Scholar]
  16. Stockley R. A., Hill S. L., Morrison H. M. Effect of antibiotic treatment on sputum elastase in bronchiectatic outpatients in a stable clinical state. Thorax. 1984 Jun;39(6):414–419. doi: 10.1136/thx.39.6.414. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stockley R. A. Measurement of soluble proteins in lung secretions. Thorax. 1984 Apr;39(4):241–247. doi: 10.1136/thx.39.4.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wiggins J., Elliott J. A., Stevenson R. D., Stockley R. A. Effect of corticosteroids on sputum sol-phase protease inhibitors in chronic obstructive pulmonary disease. Thorax. 1982 Sep;37(9):652–656. doi: 10.1136/thx.37.9.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wiggins J., Hill S. L., Stockley R. A. Lung secretion sol-phase proteins: comparison of sputum with secretions obtained by direct sampling. Thorax. 1983 Feb;38(2):102–107. doi: 10.1136/thx.38.2.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wiggins J., Stockley R. A. Variability in sputum sol phase proteins in chronic obstructive bronchitis. The value of using albumin for standardization. Am Rev Respir Dis. 1983 Jul;128(1):60–64. doi: 10.1164/arrd.1983.128.1.60. [DOI] [PubMed] [Google Scholar]
  21. Wiggins J., Stockley R. A. Variability in the secretory IgA system in sputum sol phase in stable chronic obstructive bronchitis. Eur J Respir Dis. 1984 Aug;65(6):433–440. [PubMed] [Google Scholar]
  22. von Kleist S., Chavanel G., Burtin P. Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2492–2494. doi: 10.1073/pnas.69.9.2492. [DOI] [PMC free article] [PubMed] [Google Scholar]

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