Abstract
A 60 year old woman non-smoker with bronchial asthma of 6 years' duration, treated with aminophylline, salbutamol, and oral corticosteroids, was admitted because of increasing dyspnoea and productive cough. On examination she was in moderate respiratory distress with inspiratory and expiratory wheezes. Her chest radiograph was interpreted as normal. Two consecutive sputum examinations requested by a junior doctor reveal "malignant" cells.
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- ALLAN W. B., WHITTLESEY P. The results of the experimental use of sulfur dioxide in the production of material for cell studies in lung cancer. Ann Intern Med. 1960 Feb;52:326–329. doi: 10.7326/0003-4819-52-2-326. [DOI] [PubMed] [Google Scholar]
- Band P., Feldstein M., Saccomanno G., Watson L., King G. Potentiation of cigarette smoking and radiation: evidence from a sputum cytology survey among uranium miners and controls. Cancer. 1980 Mar 15;45(6):1273–1277. doi: 10.1002/1097-0142(19800315)45:6<1273::aid-cncr2820450602>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
- Band P., Feldstein M., Watson L., King G., Saccomanno G. Lung cancer screening programs in Canadian uranium mines. Recent Results Cancer Res. 1982;82:153–158. doi: 10.1007/978-3-642-81768-7_15. [DOI] [PubMed] [Google Scholar]
- Bedrossian C. W., Rybka D. L. Bronchial brushing during fiberoptic bronchoscopy for the cytodiagnosis of lung cancer: comparison with sputum and bronchial washings. Acta Cytol. 1976 Sep-Oct;20(5):446–453. [PubMed] [Google Scholar]
- Berlin N. I., Buncher C. R., Fontana R. S., Frost J. K., Melamed M. R. The National Cancer Institute Cooperative Early Lung Cancer Detection Program. Results of the initial screen (prevalence). Early lung cancer detection: Introduction. Am Rev Respir Dis. 1984 Oct;130(4):545–549. doi: 10.1164/arrd.1984.130.4.545. [DOI] [PubMed] [Google Scholar]
- Clee M. D., Sinclair D. J. Assessment of factors influencing the result of sputum cytology in bronchial carcinoma. Thorax. 1981 Feb;36(2):143–146. doi: 10.1136/thx.36.2.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cortese D. A., Pairolero P. C., Bergstralh E. J., Woolner L. B., Uhlenhopp M. A., Piehler J. M., Sanderson D. R., Bernatz P. E., Williams D. E., Taylor W. F. Roentgenographically occult lung cancer. A ten-year experience. J Thorac Cardiovasc Surg. 1983 Sep;86(3):373–380. [PubMed] [Google Scholar]
- DOLL R., HILL A. B. MORTALITY IN RELATION TO SMOKING: TEN YEARS' OBSERVATIONS OF BRITISH DOCTORS. Br Med J. 1964 May 30;1(5395):1399–1410. doi: 10.1136/bmj.1.5395.1399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duguid H. L., Huish D. W. Clinical Evaluation of Cytodiagnosis in Bronchial Carcinoma. Br Med J. 1963 Aug 3;2(5352):287–291. doi: 10.1136/bmj.2.5352.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eddy D. M. Finding cancer in asymptomatic people. Estimating the benefits, costs and risks. Cancer. 1983 Jun 15;51(12 Suppl):2440–2445. doi: 10.1002/1097-0142(19830615)51:12+<2440::aid-cncr2820511309>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- Erozan Y. S., Frost J. K. Cytopathologic diagnosis of cancer in pulmonary material: a critical histopathologic correlation. Acta Cytol. 1970 Nov-Dec;14(9):560–565. [PubMed] [Google Scholar]
- Evans D. M., Shelley G. Respiratory cytodiagnosis: study in observer variation and its relation to quality of material. Thorax. 1982 Apr;37(4):259–263. doi: 10.1136/thx.37.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Flehinger B. J., Melamed M. R., Zaman M. B., Heelan R. T., Perchick W. B., Martini N. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Memorial Sloan-Kettering study. Am Rev Respir Dis. 1984 Oct;130(4):555–560. doi: 10.1164/arrd.1984.130.4.555. [DOI] [PubMed] [Google Scholar]
- Fontana R. S., Sanderson D. R., Taylor W. F., Woolner L. B., Miller W. E., Muhm J. R., Uhlenhopp M. A. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Mayo Clinic study. Am Rev Respir Dis. 1984 Oct;130(4):561–565. doi: 10.1164/arrd.1984.130.4.561. [DOI] [PubMed] [Google Scholar]
- Frost J. K., Ball W. C., Jr, Levin M. L., Tockman M. S., Baker R. R., Carter D., Eggleston J. C., Erozan Y. S., Gupta P. K., Khouri N. F. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Johns Hopkins study. Am Rev Respir Dis. 1984 Oct;130(4):549–554. doi: 10.1164/arrd.1984.130.4.549. [DOI] [PubMed] [Google Scholar]
- Gagneten C. B., Geller C. E., Del Carmen Saenz M. Diagnosis of bronchogenic carcinoma through the cytologic examination of sputum, with special reference to tumor typing. Acta Cytol. 1976 Nov-Dec;20(6):530–536. [PubMed] [Google Scholar]
- Geddes D. M. The natural history of lung cancer: a review based on rates of tumour growth. Br J Dis Chest. 1979 Jan;73(1):1–17. [PubMed] [Google Scholar]
- Gofin R., Kark J. D., Friedlander Y. Cigarette smoking, blood pressure and pulse rate in the Jerusalem Lipid Research Clinic Prevalence Study. Isr J Med Sci. 1982 Dec;18(12):1217–1222. [PubMed] [Google Scholar]
- HINSON K. F., KUPER S. W. THE DIAGNOSIS OF LUNG CANCER BY EXAMINATION OF SPUTUM. Thorax. 1963 Dec;18:350–353. doi: 10.1136/thx.18.4.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hayata Y., Funatsu H., Kato H., Saito Y., Sawamura K., Furose K. Results of lung cancer screening programs in Japan. Recent Results Cancer Res. 1982;82:163–173. doi: 10.1007/978-3-642-81768-7_17. [DOI] [PubMed] [Google Scholar]
- Jay S. J., Wehr K., Nicholson D. P., Smith A. L. Diagnostic sensitivity and specificity of pulmonary cytology: comparison of techniques used in conjunction with flexible fiber optic bronchoscopy. Acta Cytol. 1980 Jul-Aug;24(4):304–312. [PubMed] [Google Scholar]
- Johnston W. W., Bossen E. H. Ten years of respiratory cytopathology at Duke University Medical Center. I. The cytopathologic diagnosis of lung cancer during the years 1970 to 1974, noting the significance of specimen number and type. Acta Cytol. 1981 Mar-Apr;25(2):103–107. [PubMed] [Google Scholar]
- Johnston W. W., Frable W. J. The cytopathology of the respiratory tract. A review. Am J Pathol. 1976 Aug;84(2):372–424. [PMC free article] [PubMed] [Google Scholar]
- KOSS L. G., MELAMED M. R., GOODNER J. T. PULMONARY CYTOLOGY--A BRIEF SURVEY OF DIAGNOSTIC RESULTS FROM JULY 1ST 1952 UNTIL DECEMBER 31ST, 1960. Acta Cytol. 1964 Mar-Apr;8:104–113. [PubMed] [Google Scholar]
- Kobusch A. B., Simard A., Feldstein M., Vauclair R., Gibbs G. W., Bergeron F., Morissette N., Davis R. Pulmonary cytology in chrysotile asbestos workers. J Chronic Dis. 1984;37(8):599–607. doi: 10.1016/0021-9681(84)90109-7. [DOI] [PubMed] [Google Scholar]
- Kotin P., Paul W. Results of a lung cancer detection program in an asbestos industry. Recent Results Cancer Res. 1982;82:131–137. doi: 10.1007/978-3-642-81768-7_12. [DOI] [PubMed] [Google Scholar]
- Levin M. L., Tockman M. S., Frost J. K., Ball W. C., Jr Lung cancer mortality in males screened by chest X-ray and cytologic sputum examination: a preliminary report. Recent Results Cancer Res. 1982;82:138–146. doi: 10.1007/978-3-642-81768-7_13. [DOI] [PubMed] [Google Scholar]
- Martini N., Melamed M. R. Occult carcinomas of the lung. Ann Thorac Surg. 1980 Sep;30(3):215–223. doi: 10.1016/s0003-4975(10)61248-9. [DOI] [PubMed] [Google Scholar]
- Mitchell D. M., Emerson C. J., Collyer J., Collins J. V. Fibreoptic bronchoscopy: ten years on. Br Med J. 1980 Aug 2;281(6236):360–363. doi: 10.1136/bmj.281.6236.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nasiell M., Kinnman J., Haglund S., Roger V., Nasiell K. Detection of early and roentgenologically occult bronchogenic carcinoma: preliminary report of the Sabbatsberg hospital sputum cytologic screening study. Recent Results Cancer Res. 1982;82:159–162. doi: 10.1007/978-3-642-81768-7_16. [DOI] [PubMed] [Google Scholar]
- Ng A. B., Horak G. C. Factors significant in the diagnostic accuracy of lung cytology in bronchial washing and sputum samples. II. Sputum samples. Acta Cytol. 1983 Jul-Aug;27(4):397–402. [PubMed] [Google Scholar]
- Payne C. R., Stovin P. G., Barker V., McVittie S., Stark J. E. Diagnostic accuracy of cytology and biopsy in primary bronchial carcinoma. Thorax. 1979 Jun;34(3):294–299. doi: 10.1136/thx.34.3.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pilotti S., Rilke F., Gribaudi G., Ravasi G. L. Sputum cytology for the diagnosis of carcinoma of the lung. Acta Cytol. 1982 Sep-Oct;26(5):649–654. [PubMed] [Google Scholar]
- RUSSELL W. O., NEIDHARDT H. W., MOUNTAIN C. F., GRIFFITH K. M., CHANG J. P. Cytodiagnosis of lung cancer: a report of four-year laboratory, clinical study with a review of the literature on lung cancer and pulmonary cytology. Acta Cytol. 1963 Jan-Feb;7:1–44. [PubMed] [Google Scholar]
- Rogot E., Murray J. L. Smoking and causes of death among U.S. veterans: 16 years of observation. Public Health Rep. 1980 May-Jun;95(3):213–222. [PMC free article] [PubMed] [Google Scholar]
- Rosa U. W., Prolla J. C., Gastal E. da S. Cytology in diagnosis of cancer affecting the lung. Results in 1,000 consecutive patients. Chest. 1973 Feb;63(2):203–207. doi: 10.1378/chest.63.2.203. [DOI] [PubMed] [Google Scholar]
- Saccomanno G., Archer V. E., Auerbach O., Saunders R. P., Brennan L. M. Development of carcinoma of the lung as reflected in exfoliated cells. Cancer. 1974 Jan;33(1):256–270. doi: 10.1002/1097-0142(197401)33:1<256::aid-cncr2820330139>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
- Saccomanno G. The contribution of uranium miners to lung cancer histogenesis. Recent Results Cancer Res. 1982;82:43–52. doi: 10.1007/978-3-642-81768-7_5. [DOI] [PubMed] [Google Scholar]
- Saffiotti U., Montesano R., Sellakumar A. R., Borg S. A. Experimental cancer of the lung. Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors. Cancer. 1967 May;20(5):857–864. doi: 10.1002/1097-0142(1967)20:5<857::aid-cncr2820200545>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Sanderson D., Fontana R. Results of Mayo lung project: an interim report. Recent Results Cancer Res. 1982;82:179–186. doi: 10.1007/978-3-642-81768-7_19. [DOI] [PubMed] [Google Scholar]
- Seidenfeld J. J. Screening for bronchogenic carcinoma. Ann Intern Med. 1985 Jun;102(6):851–852. doi: 10.7326/0003-4819-102-6-851. [DOI] [PubMed] [Google Scholar]
- Silverberg E. Cancer statistics, 1984. CA Cancer J Clin. 1984 Jan-Feb;34(1):7–23. doi: 10.3322/canjclin.34.1.7. [DOI] [PubMed] [Google Scholar]
- Spriggs A. I., Cole M., Dunnill M. S. Alveolar-cell carcinoma: a problem in sputum cytodiagnosis. J Clin Pathol. 1982 Dec;35(12):1370–1379. doi: 10.1136/jcp.35.12.1370. [DOI] [PMC free article] [PubMed] [Google Scholar]
- UMIKER W. O. Diagnosis of bronchogenic carcinoma: an evaluation of pulmonary cytology, bronchoscopy and scalene lymph node biopsy. Dis Chest. 1960 Jan;37:82–90. doi: 10.1378/chest.37.1.82. [DOI] [PubMed] [Google Scholar]
- Yoneyama T., Canlas M. S. From "exfoliative" to "diagnostic" cytology. A statistical evaluation of pulmonary cytology. Acta Cytol. 1978 May-Jun;22(3):158–161. [PubMed] [Google Scholar]