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. 1988 Jan;43(1):65–70. doi: 10.1136/thx.43.1.65

Cigarette smoke inhalation patterns and bronchial reactivity.

D R Taylor 1, W D Reid 1, P D Paré 1, J A Fleetham 1
PMCID: PMC461101  PMID: 3353877

Abstract

The manner in which a cigarette is smoked varies considerably between individuals and may be an important determinant of the altered bronchial reactivity observed in cigarette smokers. Twenty smokers were examined to determine the relationship between cigarette smoke inhalation patterns and bronchial reactivity. Inhalation patterns were measured non-invasively with a respiratory inductive plethysmograph and these were related to the provocative concentration of histamine that caused a 20% fall in FEV1 (PC20) and to the cough threshold for inhaled citric acid. Histamine PC20 values were inversely correlated with depth and rate of inhalation. Cough threshold was inversely correlated with greater cigarette consumption and with depth of inhalation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BICKERMAN H. A., BARACH A. L. The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents. Am J Med Sci. 1954 Aug;228(2):156–163. doi: 10.1097/00000441-195408000-00005. [DOI] [PubMed] [Google Scholar]
  2. Brain J. D., Valberg P. A. Deposition of aerosol in the respiratory tract. Am Rev Respir Dis. 1979 Dec;120(6):1325–1373. doi: 10.1164/arrd.1979.120.6.1325. [DOI] [PubMed] [Google Scholar]
  3. Brown N. E., McFadden E. R., Jr, Ingram R. H., Jr Airway responses to inhaled histamine in asymptomatic smokers and nonsmokers. J Appl Physiol Respir Environ Exerc Physiol. 1977 Apr;42(4):508–513. doi: 10.1152/jappl.1977.42.4.508. [DOI] [PubMed] [Google Scholar]
  4. Buczko G. B., Day A., Vanderdoelen J. L., Boucher R., Zamel N. Effects of cigarette smoking and short-term smoking cessation on airway responsiveness to inhaled methacholine. Am Rev Respir Dis. 1984 Jan;129(1):12–14. doi: 10.1164/arrd.1984.129.1.12. [DOI] [PubMed] [Google Scholar]
  5. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  6. Eschenbacher W. L., Boushey H. A., Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis. 1984 Feb;129(2):211–215. [PubMed] [Google Scholar]
  7. Gerrard J. W., Cockcroft D. W., Mink J. T., Cotton D. J., Poonawala R., Dosman J. A. Increased nonspecific bronchial reactivity in cigarette smokers with normal lung function. Am Rev Respir Dis. 1980 Oct;122(4):577–581. doi: 10.1164/arrd.1980.122.4.577. [DOI] [PubMed] [Google Scholar]
  8. Juniper E. F., Frith P. A., Dunnett C., Cockcroft D. W., Hargreave F. E. Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax. 1978 Dec;33(6):705–710. doi: 10.1136/thx.33.6.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kennedy S. M., Elwood R. K., Wiggs B. J., Paré P. D., Hogg J. C. Increased airway mucosal permeability of smokers. Relationship to airway reactivity. Am Rev Respir Dis. 1984 Jan;129(1):143–148. doi: 10.1164/arrd.1984.129.1.143. [DOI] [PubMed] [Google Scholar]
  10. Lam S., Wong R., Yeung M. Nonspecific bronchial reactivity in occupational asthma. J Allergy Clin Immunol. 1979 Jan;63(1):28–34. doi: 10.1016/0091-6749(79)90158-1. [DOI] [PubMed] [Google Scholar]
  11. Malo J. L., Filiatrault S., Martin R. R. Bronchial responsiveness to inhaled methacholine in young asymptomatic smokers. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jun;52(6):1464–1470. doi: 10.1152/jappl.1982.52.6.1464. [DOI] [PubMed] [Google Scholar]
  12. McFadden E. R., Jr Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma. N Engl J Med. 1975 Mar 13;292(11):555–559. doi: 10.1056/NEJM197503132921103. [DOI] [PubMed] [Google Scholar]
  13. McIntyre E. L., Ruffin R. E., Alpers J. H. Lack of short-term effects of cigarette smoking on bronchial sensitivity to histamine and methacholine. Eur J Respir Dis. 1982 Nov;63(6):535–542. [PubMed] [Google Scholar]
  14. Pavia D., Thomson M. L., Clarke S. W., Shannon H. S. Effect of lung function and mode of inhalation on penetration of aerosol into the human lung. Thorax. 1977 Apr;32(2):194–197. doi: 10.1136/thx.32.2.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pounsford J. C., Saunders K. B. Diurnal variation and adaptation of the cough response to citric acid in normal subjects. Thorax. 1985 Sep;40(9):657–661. doi: 10.1136/thx.40.9.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sheppard D., Rizk N. W., Boushey H. A., Bethel R. A. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis. 1983 Jun;127(6):691–694. doi: 10.1164/arrd.1983.127.6.691. [DOI] [PubMed] [Google Scholar]
  17. Taylor R. G., Joyce H., Gross E., Holland F., Pride N. B. Bronchial reactivity to inhaled histamine and annual rate of decline in FEV1 in male smokers and ex-smokers. Thorax. 1985 Jan;40(1):9–16. doi: 10.1136/thx.40.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Thomson N. C. The effect of different pharmacological agents on respiratory reflexes in normal and asthmatic subjects. Clin Sci (Lond) 1979 Mar;56(3):235–241. doi: 10.1042/cs0560235. [DOI] [PubMed] [Google Scholar]
  19. Tobin M. J., Jenouri G., Sackner M. A. Subjective and objective measurement of cigarette smoke inhalation. Chest. 1982 Dec;82(6):696–700. doi: 10.1378/chest.82.6.696. [DOI] [PubMed] [Google Scholar]
  20. Tobin M. J., Sackner M. A. Monitoring smoking patterns of low and high tar cigarettes with inductive plethysmography. Am Rev Respir Dis. 1982 Aug;126(2):258–264. doi: 10.1164/arrd.1982.126.2.258. [DOI] [PubMed] [Google Scholar]
  21. Turner J. A., Sillett R. W., McNicol M. W. Effect of cigar smoking on carboxyhaemoglobin and plasma nicotine concentrations in primary pipe and cigar smokers and ex-cigarette smokers. Br Med J. 1977 Nov 26;2(6099):1387–1389. doi: 10.1136/bmj.2.6099.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wanner A., Brodnan J. M., Perez J., Henke K. G., Kim C. S. Variability of airway responsiveness to histamine aerosol in normal subjects. Role of deposition. Am Rev Respir Dis. 1985 Jan;131(1):3–7. doi: 10.1164/arrd.1985.131.S5.S3. [DOI] [PubMed] [Google Scholar]
  23. Warner K. E. Toward less hazardous cigarettes. JAMA. 1979 May 18;241(20):2143–2144. [PubMed] [Google Scholar]
  24. White J. R., Froeb H. F. Small-airways dysfunction in nonsmokers chronically exposed to tobacco smoke. N Engl J Med. 1980 Mar 27;302(13):720–723. doi: 10.1056/NEJM198003273021304. [DOI] [PubMed] [Google Scholar]

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