Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1988 Jun;43(6):456–461. doi: 10.1136/thx.43.6.456

Relation of perceived nasal and bronchial hyperresponsiveness to FEV1, basophil counts, and methacholine response.

F Kauffmann 1, F Neukirch 1, I Annesi 1, M Korobaeff 1, M F Doré 1, J Lellouch 1
PMCID: PMC461310  PMID: 3420556

Abstract

Perceived nasal and bronchial hyperresponsiveness to tobacco smoke and cold air were assessed in 912 working men in the Paris area. Baseline lung function measurements and peripheral leucocyte counts with standard differential counts were performed. At least one perceived nasal or bronchial hyperresponsiveness symptom was reported by 15.7%. Current smoking was significantly less frequent among those with cough induced by tobacco smoke. Rhinitis induced by cold air was associated with lower FEV1 (p less than 0.01) and the association remained after adjustment for smoking, asthma, and wheezing (p = 0.06). Symptoms induced by cold air were related to circulating basophils. Neither perceived nasal nor perceived bronchial hyperresponsiveness was significantly related to the airway response to methacholine in a sample of the group (n = 324) surveyed again five years later. The result suggest that the symptom of rhinitis provoked by cold air is a possible "new" risk factor or marker for chronic airflow limitation.

Full text

PDF
458

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Annesi I., Neukirch F., Orvoen-Frija E., Oryszczyn M. P., Korobaeff M., Doré M. F., Kauffmann F. The relevance of hyperresponsiveness but not of atopy to FEV1 decline. Preliminary results in a working population. Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):397–400. [PubMed] [Google Scholar]
  2. Annesi I., Neukirch F., Orvoen-Frija E., Oryszczyn M. P., Korobaeff M., Kauffman F. Respiratory symptoms and bronchial reactivity. Br Med J (Clin Res Ed) 1986 Nov 8;293(6556):1237–1238. doi: 10.1136/bmj.293.6556.1237-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bell N. H. Vitamin D-endocrine system. J Clin Invest. 1985 Jul;76(1):1–6. doi: 10.1172/JCI111930. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloom J. W., Halonen M., Dunn A. M., Pinnas J. L., Burrows B. Pneumococcus-specific immunoglobulin E in cigarette smokers. Clin Allergy. 1986 Jan;16(1):25–32. doi: 10.1111/j.1365-2222.1986.tb01950.x. [DOI] [PubMed] [Google Scholar]
  5. Burrows B., Lebowitz M. D., Barbee R. A., Knudson R. J., Halonen M. Interactions of smoking and immunologic factors in relation to airways obstruction. Chest. 1983 Dec;84(6):657–661. doi: 10.1378/chest.84.6.657. [DOI] [PubMed] [Google Scholar]
  6. Cockcroft D. W., Berscheid B. A., Murdock K. Y. Unimodal distribution of bronchial responsiveness to inhaled histamine in a random human population. Chest. 1983 May;83(5):751–754. doi: 10.1378/chest.83.5.751. [DOI] [PubMed] [Google Scholar]
  7. Cookson W. O., Ryan G., MacDonald S., Musk A. W. Atopy, non-allergic bronchial reactivity, and past history as determinants of work related symptoms in seasonal grain handlers. Br J Ind Med. 1986 Jun;43(6):396–400. doi: 10.1136/oem.43.6.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Eisen E. A., Robins J. M., Greaves I. A., Wegman D. H. Selection effects of repeatability criteria applied to lung spirometry. Am J Epidemiol. 1984 Nov;120(5):734–742. doi: 10.1093/oxfordjournals.aje.a113941. [DOI] [PubMed] [Google Scholar]
  9. Fletcher C. M., Pride N. B. Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the Ciba symposium. Thorax. 1984 Feb;39(2):81–85. doi: 10.1136/thx.39.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kauffmann F., Neukirch F., Korobaeff M., Marne M. J., Claude J. R., Lellouch J. Eosinophils, smoking, and lung function. An epidemiologic survey among 912 working men. Am Rev Respir Dis. 1986 Dec;134(6):1172–1175. doi: 10.1164/arrd.1986.134.6.1172. [DOI] [PubMed] [Google Scholar]
  11. Kauffmann F., Neukirch F., Martin J. P., Claude J. R. Relationships between functional measurements and childhood respiratory diseases according to the age of onset. Eur J Respir Dis. 1987 Feb;70(2):78–85. [PubMed] [Google Scholar]
  12. Kauffmann F., Querleux E., Drouet D., Lellouch J., Brille D. Evolution du VEMS en 12 ans et tabagisme chez 556 travailleurs de la région parisienne. Bull Eur Physiopathol Respir. 1979 Sep-Oct;15(5):723–737. [PubMed] [Google Scholar]
  13. Kimura I., Moritani Y., Tanizaki Y. Basophils in bronchial asthma with reference to reagin-type allergy. Clin Allergy. 1973 Jun;3(2):195–202. doi: 10.1111/j.1365-2222.1973.tb01321.x. [DOI] [PubMed] [Google Scholar]
  14. Lebowitz M. D. Smoking habits and changes in smoking habits as they relate to chronic conditions and respiratory symptoms. Am J Epidemiol. 1977 Jun;105(6):534–543. doi: 10.1093/oxfordjournals.aje.a112417. [DOI] [PubMed] [Google Scholar]
  15. Lehrer S. B., Barbandi F., Taylor J. P., Salvaggio J. E. Tobacco smoke "sensitivity"--is there an immunologic basis? J Allergy Clin Immunol. 1984 Feb;73(2):240–245. doi: 10.1016/s0091-6749(84)80014-7. [DOI] [PubMed] [Google Scholar]
  16. Mortagy A. K., Howell J. B., Waters W. E. Respiratory symptoms and bronchial reactivity: identification of a syndrome and its relation to asthma. Br Med J (Clin Res Ed) 1986 Aug 30;293(6546):525–529. doi: 10.1136/bmj.293.6546.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Neukirch F. E., Kauffmann F., Korobaeff M., Liard R. Common cold with cough on the day of examination: a factor that should be taken into account in epidemiological studies on pulmonary function. Int J Epidemiol. 1985 Dec;14(4):635–636. doi: 10.1093/ije/14.4.635. [DOI] [PubMed] [Google Scholar]
  18. Pride N. B., Taylor R. G., Lim T. K., Joyce H., Watson A. Bronchial hyperresponsiveness as a risk factor for progressive airflow obstruction in smokers. Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):369–375. [PubMed] [Google Scholar]
  19. Pride N. Smoking, allergy and airways obstruction: revival of the 'Dutch hypothesis'. Clin Allergy. 1986 Jan;16(1):3–6. doi: 10.1111/j.1365-2222.1986.tb01946.x. [DOI] [PubMed] [Google Scholar]
  20. Weiss S. T., Speizer F. E. Increased levels of airways responsiveness as a risk factor for development of chronic obstructive lung disease. What are the issues? Chest. 1984 Jul;86(1):3–4. doi: 10.1378/chest.86.1.3. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES