Abstract
Nocardia organisms were cultured from the sputum of 11 patients at the central hospitals in Harare, Zimbabwe, over a 12 month period. Pulmonary nocardiosis was diagnosed in one further patient on the basis of direct microscopy. Among the nine patients available for follow up, pulmonary nocardiosis was considered to be the major clinical problem in six. The patients usually presented with a chronic pulmonary infection with fever and cough without evidence of dissemination of underlying systemic disease. The chest radiograph showed consolidation in any part of the lung, and this was seen to extend slowly over several months. Prolonged diagnostic delay was a frequent problem. Haemoptysis, alcohol abuse, and empirical treatment for tuberculosis commonly featured in the history. Treatment with sulphonamides was generally successful in those patients who complied. Nocardiosis is a treatable lung disease that may be more common in developing countries than is currently recognised.
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- Aron R., Gordon W. Pulmonary nocardiosis. case report and evaluation of current therapy. S Afr Med J. 1972 Jan 8;46(2):29–32. [PubMed] [Google Scholar]
- Beaman B. L., Burnside J., Edwards B., Causey W. Nocardial infections in the United States, 1972-1974. J Infect Dis. 1976 Sep;134(3):286–289. doi: 10.1093/infdis/134.3.286. [DOI] [PubMed] [Google Scholar]
- Curry W. A. Human nocardiosis. A clinical review with selected case reports. Arch Intern Med. 1980 Jun;140(6):818–826. doi: 10.1001/archinte.140.6.818. [DOI] [PubMed] [Google Scholar]
- Frazier A. R., Rosenow E. C., 3rd, Roberts G. D. Nocardiosis. A review of 25 cases occurring during 24 months. Mayo Clin Proc. 1975 Nov;50(11):657–663. [PubMed] [Google Scholar]
- HOSTY T. S., McDURMONT C., AJELLO L., GEORG L. K., BRUMFIELD G. L., CALIX A. A. Prevalence of Nocardia asteroides in sputa examined by a tuberculosis diagnostic laboratory. J Lab Clin Med. 1961 Jul;58:107–114. [PubMed] [Google Scholar]
- Kinyoun J. J. A NOTE ON UHLENHUTHS METHOD FOR SPUTUM EXAMINATION, FOR TUBERCLE BACILLI. Am J Public Health (N Y) 1915 Sep;5(9):867–870. doi: 10.2105/ajph.5.9.867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C., Silva M., Hazen E., Rosenheim S. H. Necrotizing nocardial pneumonitis. Ann Intern Med. 1967 Feb;66(2):274–284. doi: 10.7326/0003-4819-66-2-274. [DOI] [PubMed] [Google Scholar]
- Orchard V. A., Goodfellow M. The selective isolation of nocardia from soil using antibiotics. J Gen Microbiol. 1974 Nov;85(1):160–162. doi: 10.1099/00221287-85-1-160. [DOI] [PubMed] [Google Scholar]
- Osoagbaka O. U., Njoku-Obi A. N. Nocardiosis in pulmonary diseases in parts of Nigeria. I. Preliminary observations on five cases. J Trop Med Hyg. 1985 Dec;88(6):367–372. [PubMed] [Google Scholar]
- Petrillo V. F., Severo L. C., Londero A. T., Porto N. S. Pulmonary nocardiosis report of the first two Brazilian cases. Mycopathologia. 1978 Dec 29;66(1-2):17–20. doi: 10.1007/BF00429587. [DOI] [PubMed] [Google Scholar]
- RAICH R. A., CASEY F., HALL W. H. Pulmonary and cutaneous nocardiosis. The significance of the laboratory isolation of Nocardia. Am Rev Respir Dis. 1961 Apr;83:505–509. doi: 10.1164/arrd.1961.83.4.505. [DOI] [PubMed] [Google Scholar]
- Randhawa H. S., Mishra S. K., Sandhu R. S., Mazumdar P. R., Jain R. C., Rao P. U., Parkash D., Viswanathan R., Subramanian S., Sharma V. N. Prevalence of nocardiosis in bronchopulmonary diseases. Indian J Med Res. 1973 May;61(5):689–699. [PubMed] [Google Scholar]
- Smego R. A., Jr, Moeller M. B., Gallis H. A. Trimethoprim-sulfamethoxazole therapy for Nocardia infections. Arch Intern Med. 1983 Apr;143(4):711–718. [PubMed] [Google Scholar]
- Stevens D. A. Clinical and clinical laboratory aspects of nocardial infection. J Hyg (Lond) 1983 Dec;91(3):377–384. doi: 10.1017/s0022172400060423. [DOI] [PMC free article] [PubMed] [Google Scholar]