Abstract
An impactor method was used to assess the amount of beclomethasone dipropionate in particles less than 5 microns produced by two nebulisers (Pari Inhalierboy, Medix Traveller compressor with cirrhus nebuliser chamber) and two spacer devices (Volumatic and Nebuhaler). After nebulisation of 3 ml (150 micrograms) beclomethasone dipropionate the amount of drug in particles less than 5 microns was 16 micrograms (GSD 1.1) with the Pari Inhalierboy, and 27 micrograms (1.4) with the Medix Traveller with cirrhus nebuliser. This was less than the amount in particles less than 5 microns after three metered dose inhaler actuations (150 micrograms) from the Nebuhaler (58.2 (1) micrograms) or the Volumatic spacer (46.5 (1) micrograms). The greater amount of beclomethasone dipropionate in small particles with administration from a metered dose inhaler with a spacer device means that considerably more drug is likely to reach the airways than when the same dose is given by the two nebulisers studied.
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- Carlsen K. H., Leegaard J., Larsen S., Orstavik I. Nebulised beclomethasone dipropionate in recurrent obstructive episodes after acute bronchiolitis. Arch Dis Child. 1988 Dec;63(12):1428–1433. doi: 10.1136/adc.63.12.1428. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maayan C., Itzhaki T., Bar-Yishay E., Gross S., Tal A., Godfrey S. The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate. Pediatr Pulmonol. 1986 Jan-Feb;2(1):9–14. doi: 10.1002/ppul.1950020106. [DOI] [PubMed] [Google Scholar]
- Mundy A. R. Artificial urinary sphincters. Arch Dis Child. 1986 Jan;61(1):1–3. doi: 10.1136/adc.61.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C., Clark A. R., Milner A. D. Why nebulise for more than five minutes? Arch Dis Child. 1989 Sep;64(9):1270–1273. doi: 10.1136/adc.64.9.1270. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C., Milner A. D., Swarbrick A. Spacer device with face mask attachment for giving bronchodilators to infants with asthma. BMJ. 1989 Jan 21;298(6667):160–161. doi: 10.1136/bmj.298.6667.160. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Storr J., Lenney C. A., Lenney W. Nebulised beclomethasone dipropionate in preschool asthma. Arch Dis Child. 1986 Mar;61(3):270–273. doi: 10.1136/adc.61.3.270. [DOI] [PMC free article] [PubMed] [Google Scholar]