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. 1990 Oct;45(10):728–732. doi: 10.1136/thx.45.10.728

Jet and ultrasonic nebuliser output: use of a new method for direct measurement of aerosol output.

J H Dennis 1, S C Stenton 1, J R Beach 1, A J Avery 1, E H Walters 1, D J Hendrick 1
PMCID: PMC462714  PMID: 2247862

Abstract

Output from jet nebulisers is calibrated traditionally by weighing them before and after nebulisation, but the assumption that the weight difference is a close measure of aerosol generation could be invalidated by the concomitant process of evaporation. A method has been developed for measuring aerosol output directly by using a solute (fluoride) tracer and aerosol impaction, and this has been compared with the traditional weight loss method for two Wright, six Turbo, and four Micro-Cirrus jet nebulisers and two Microinhaler ultrasonic nebulisers. The weight loss method overestimated true aerosol output for all jet nebulisers. The mean aerosol content, expressed as a percentage of the total weight loss, varied from as little as 15% for the Wright jet nebulisers to 54% (range 45-61%) for the Turbo and Micro-Cirrus jet nebulisers under the operating conditions used. In contrast, there was no discrepancy between weight loss and aerosol output for the ultrasonic nebulisers. These findings, along with evidence of both concentrating and cooling effects from jet nebulisation, confirm that total output from jet nebulisers contains two distinct fractions, vapour and aerosol. The vapour fraction, but not the aerosol fraction, was greatly influenced by reservoir temperature within the nebuliser; so the ratio of aerosol output to total weight loss varied considerably with temperature. It is concluded that weight loss is an inappropriate method of calibrating jet nebuliser aerosol output, and that this should be measured directly.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bland J. M., Altman D. G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307–310. [PubMed] [Google Scholar]
  2. Clay M. M., Clarke S. W. Wastage of drug from nebulisers: a review. J R Soc Med. 1987 Jan;80(1):38–39. doi: 10.1177/014107688708000115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clay M. M., Pavia D., Newman S. P., Clarke S. W. Factors influencing the size distribution of aerosols from jet nebulisers. Thorax. 1983 Oct;38(10):755–759. doi: 10.1136/thx.38.10.755. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clay M. M., Pavia D., Newman S. P., Lennard-Jones T., Clarke S. W. Assessment of jet nebulisers for lung aerosol therapy. Lancet. 1983 Sep 10;2(8350):592–594. doi: 10.1016/s0140-6736(83)90679-7. [DOI] [PubMed] [Google Scholar]
  5. Cockcroft D. W., Hurst T. S., Gore B. P. Importance of evaporative water losses during standardized nebulized inhalation provocation tests. Chest. 1989 Sep;96(3):505–508. doi: 10.1378/chest.96.3.505. [DOI] [PubMed] [Google Scholar]
  6. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. doi: 10.1111/j.1365-2222.1977.tb01448.x. [DOI] [PubMed] [Google Scholar]
  7. Connolly M. J., Avery A. J., Walters E. H., Hendrick D. J. The relationship between bronchial responsiveness to methacholine and bronchial responsiveness to histamine in asthmatic subjects. Pulm Pharmacol. 1988;1(1):53–58. doi: 10.1016/0952-0600(88)90011-7. [DOI] [PubMed] [Google Scholar]
  8. Crosby N. T., Dennis A. L., Stevens J. G. An evaluation of some methods for the determination of fluoride in potable waters and other aqueous solutions. Analyst. 1968 Oct;93(111):643–652. doi: 10.1039/an9689300643. [DOI] [PubMed] [Google Scholar]
  9. Donna E., Danta I., Kim C. S., Wanner A. Relationship between deposition of and responsiveness to inhaled methacholine in normal and asymptomatic subjects. J Allergy Clin Immunol. 1989 Feb;83(2 Pt 1):456–461. doi: 10.1016/0091-6749(89)90133-4. [DOI] [PubMed] [Google Scholar]
  10. Hickey A. J., Byron P. R. Effect of solution flow rate on the output of two modified commercially available jet nebulizers. J Pharm Sci. 1987 Apr;76(4):338–340. doi: 10.1002/jps.2600760415. [DOI] [PubMed] [Google Scholar]
  11. Kongerud J., Søyseth V., Johansen B. Room temperature influences output from the Wright jet nebulizer. Eur Respir J. 1989 Jul;2(7):681–684. [PubMed] [Google Scholar]
  12. Mercer T. T. Production and characterization of aerosols. Arch Intern Med. 1973 Jan;131(1):39–50. [PubMed] [Google Scholar]
  13. Newman S. P., Pellow P. G., Clarke S. W. In vitro comparison of DeVilbiss jet and ultrasonic nebulizers. Chest. 1987 Dec;92(6):991–994. doi: 10.1378/chest.92.6.991. [DOI] [PubMed] [Google Scholar]
  14. Nieminen M. M., Holli H., Lahdensuo A., Muittari A., Karvonen J. Aerosol deposition in automatic dosimeter nebulization. Eur J Respir Dis. 1987 Sep;71(3):145–152. [PubMed] [Google Scholar]
  15. O'Callaghan C., Clarke A. R., Milner A. D. Inaccurate calculation of drug output from nebulisers. Eur J Pediatr. 1989 Feb;148(5):473–474. doi: 10.1007/BF00595919. [DOI] [PubMed] [Google Scholar]
  16. Ryan G., Dolovich M. B., Obminski G., Cockcroft D. W., Juniper E., Hargreave F. E., Newhouse M. T. Standardization of inhalation provocation tests: influence of nebulizer output, particle size, and method of inhalation. J Allergy Clin Immunol. 1981 Feb;67(2):156–161. doi: 10.1016/0091-6749(81)90012-9. [DOI] [PubMed] [Google Scholar]
  17. Schöni M. H., Kraemer R. Osmolality changes in nebulizer solutions. Eur Respir J. 1989 Oct;2(9):887–892. [PubMed] [Google Scholar]
  18. Tillery M. I., Wood G. O., Ettinger H. J. Generation and characterization of aerosols and vapors for inhalation experiments. Environ Health Perspect. 1976 Aug;16:25–40. doi: 10.1289/ehp.761625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tsanakas J. N., Wilson A. J., Boon A. W. Evaluation of nebulisers for bronchial challenge tests. Arch Dis Child. 1987 May;62(5):506–508. doi: 10.1136/adc.62.5.506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. WRIGHT B. M. A new nebuliser. Lancet. 1958 Jul 5;2(7036):24–25. doi: 10.1016/s0140-6736(58)90009-6. [DOI] [PubMed] [Google Scholar]
  21. Wood J. A., Wilson R. S., Bray C. Changes in salbutamol concentration in the reservoir solution of a jet nebulizer. Br J Dis Chest. 1986 Apr;80(2):164–169. doi: 10.1016/0007-0971(86)90037-9. [DOI] [PubMed] [Google Scholar]

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