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. 1993 Apr 15;90(8):3544–3548. doi: 10.1073/pnas.90.8.3544

A virion-specific inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1.

Z Matsuda 1, X Yu 1, Q C Yu 1, T H Lee 1, M Essex 1
PMCID: PMC46337  PMID: 7682710

Abstract

A potential new approach for gene therapy against human immunodeficiency virus type 1 (HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-1 by using Vpx, a virion-associated protein of HIV-2 and simian immunodeficiency virus. Vpx was incorporated into HIV-1 virions and the resulting cell-free virus lost infectivity in CD4+ human T cells. This demonstrates the therapeutic potential of an accessory gene-based virion-specific inhibitory molecule. Vpx and its derivatives can be regarded as a new class of anti-HIV-1 molecule.

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Selected References

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