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. Author manuscript; available in PMC: 2015 Nov 24.
Published in final edited form as: Mol Psychiatry. 2014 Aug;19(8):853. doi: 10.1038/mp.2014.85

Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala

RM Birn 1,2,3,4,5,12, AJ Shackman 6,7,8,12, JA Oler 2,3,4, LE Williams 2,3,4, DR McFarlin 2,3,4,5, GM Rogers 2, SE Shelton 2, AL Alexander 1,5, DS Pine 9, MJ Slattery 2, RJ Davidson 2,3,5,10,11, AS Fox 2,3,4,5,10,11, NH Kalin 2,3,4,5,10
PMCID: PMC4657549  NIHMSID: NIHMS737428  PMID: 25055941

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(a) Children with anxiety disorders. The bottom-left panel shows the Ce seed (cyan in red ring). The upper-left panel depicts a coronal slice through the human dlPFC cluster (dark orange). The bottom-right panel shows the location of the dlPFC cluster relative to the architectonic subdivisions of the human dlPFC. (b) Monkeys with a more anxious temperament. Conventions are similar to those in (a). The bottom-right panels were adapted with permission from Badre and D’Esposito.1 For more information on this topic, please refer to the article by Birn et al. on pages 915–922.

References

  • 1.Badre D, D’Esposito M. Is the rostro-caudal axis of the frontal lobe hierarchical? Nat Rev Neurosci. 2009;10:659–669. doi: 10.1038/nrn2667. [DOI] [PMC free article] [PubMed] [Google Scholar]

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