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. 1972 Jul;27(4):429–432. doi: 10.1136/thx.27.4.429

Clinical trial of bromhexine in severe chronic bronchitics during winter

S W Clarke 1,2,3,1, G M Craig 1,2,3, E J B Makin 1,2,3
PMCID: PMC469946  PMID: 4561679

Abstract

In a double-blind, controlled cross-over trial, the effect of the mucolytic drug bromhexine (24 mg or 48 mg daily) was compared with a placebo over a period of 14 weeks in 21 severe chronic bronchitics (mean FEV1·0 0·8 1.). Each of the three treatment regimes was continued for four weeks with intervening single weeks on placebo tablets. As the subjects were outpatients, sodium fluorescein incorporated in the tablets was used as a drug marker. Satisfactory data were obtained in 18 patients. There was no significant improvement in clinical condition or ventilatory capacity nor change in sputum properties throughout the period of study. No side effects or significant change in blood values were detected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christensen S. B., Kjer J., Ryskjaer S., Arseth-Hansen P., Christensen F. Mucolytic treatment of chronic bronchitis during two winter periods. Scand J Respir Dis. 1971;52(1):48–57. [PubMed] [Google Scholar]
  2. Clarke S. W., Jones J. G., Oliver D. R. Resistance to two-phase gas-liquid flow in airways. J Appl Physiol. 1970 Oct;29(4):464–471. doi: 10.1152/jappl.1970.29.4.464. [DOI] [PubMed] [Google Scholar]
  3. Gent M., Knowlson P. A., Rime F. J. Effect of bromhexine on ventilatory capacity in patients with a variety of chest diseases. Lancet. 1969 Nov 22;2(7630):1094–1096. doi: 10.1016/s0140-6736(69)90702-8. [DOI] [PubMed] [Google Scholar]
  4. Hamilton W. F., Palmer K. N., Gent M. Expectorant action of bromhexine in chronic obstructive bronchitis. Br Med J. 1970 Aug 1;3(5717):260–261. doi: 10.1136/bmj.3.5717.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Langlands J. The dynamics of cough in health and in chronic bronchitis. Thorax. 1967 Jan;22(1):88–96. doi: 10.1136/thx.22.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Sturgess J. M., Palfrey A. J., Reid L. The viscosity of bronchial secretion. Clin Sci. 1970 Jan;38(1):145–156. doi: 10.1042/cs0380145. [DOI] [PubMed] [Google Scholar]
  7. Thompson R. H., Stowers J. M. The use of a drug marker in a clinical trial. Scott Med J. 1971 May;16(5):259–260. doi: 10.1177/003693307101600505. [DOI] [PubMed] [Google Scholar]

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