Abstract
A method is described for the early clinical evaluation of bronchodilator aerosols. It is simple to perform, and an accurate estimate of potency can be obtained in a small number of patients. Using this method, three new sympathomimetic drugs, Th 1165a, salmefamol, and rimiterol, have been tested. All proved to be active bronchodilators and were equipotent with isoprenaline or salbutamol.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alliott R. J., Lang B. D., Rawson D. R., Leckie W. J. Effects of salbutamol and isoprenaline-phenylephrine in reversible airways obstruction. Br Med J. 1972 Feb 26;1(5799):539–542. doi: 10.1136/bmj.1.5799.539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FAIRBAIRN A. S., FLETCHER C. M., TINKER C. M., WOOD C. H. A comparison of spirometric and peak expiratory flow measurements in men with and without chronic bronchitis. Thorax. 1962 Jun;17:168–174. doi: 10.1136/thx.17.2.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freedman B. J. Trial of new bronchodilator, terbutaline, in asthma. Br Med J. 1971 Mar 20;1(5750):633–636. doi: 10.1136/bmj.1.5750.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUME K. M., GANDEVIA B. Forced expiratory volume before and after isoprenaline. Thorax. 1957 Sep;12(3):276–278. doi: 10.1136/thx.12.3.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUME K. M., RHYS JONES E. The response to bronchodilators in intrinsic asthma. Q J Med. 1961 Apr;30:189–199. [PubMed] [Google Scholar]
- Hoffbrand B. I., Hoffbrand M. I., Hill I. D., Heaf P. J. Trial of bronchodilator drugs given by metered aerosol with a comparison of two bedside methods of estimating airway resistance. Br Med J. 1966 Apr 23;1(5494):1014–1016. doi: 10.1136/bmj.1.5494.1014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Minette A. Spirometric study of the bronchodilating effects of hydroxyphenylorciprenaline (Th 1165 a) in various forms in a group of 124 coal miners suffering from bronchospasm. Respiration. 1970;27(3):276–315. doi: 10.1159/000192688. [DOI] [PubMed] [Google Scholar]
- PAIN M. C., READ J. PATTERNS OF RESPONSE TO BRONCHODILATOR IN YOUNG PATIENTS WITH ASTHMA. Australas Ann Med. 1963 Aug;12:216–220. doi: 10.1111/imj.1963.12.3.216. [DOI] [PubMed] [Google Scholar]
- Paterson J. W., Conolly M. E., Davies D. S., Dollery C. T. Isoprenaline resistance and the use of pressurised aerosols in asthma. Lancet. 1968 Aug 24;2(7565):426–429. doi: 10.1016/s0140-6736(68)90467-4. [DOI] [PubMed] [Google Scholar]
- Warrell D. A., Robertson D. G., Howes J. N., Conolly M. E., Paterson J. W., Beilin L. J., Dollery C. T. Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma. Br Med J. 1970 Jan 10;1(5688):65–70. [PMC free article] [PubMed] [Google Scholar]