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. 1973 May;28(3):320–330. doi: 10.1136/thx.28.3.320

Lung function in coastal and highland New Guineans—comparison with Europeans

J E Cotes 1,2, M J Saunders 1,2, J E R Adam 1,2, H R Anderson 1,2, A M Hall 1,2
PMCID: PMC470036  PMID: 4724500

Abstract

The lung volumes, ventilatory capacity, and transfer factor of young adult male and female New Guineans living at sea level, after standardization for age, height, and, in the case of transfer factor, the haemoglobin concentration, resemble those of people of Indian and West African descent. The inspiratory capacity and expiratory reserve volume are smaller than for comparable Europeans. The highland New Guineans have a larger total lung capacity and transfer factor than the coastal dwellers due mainly to a larger inspiratory capacity. Compared with representative Europeans, the highlanders have a similar total lung capacity but larger transfer factor. The exceptional lung function of the New Guinea highlanders is not closely related to altitude and is probably determined at least in part by their present mode of life entailing a high level of habitual activity. This factor needs to be taken into account when considering `normal values'.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrew G. M., Becklake M. R., Guleria J. S., Bates D. V. Heart and lung functions in swimmers and nonathletes during growth. J Appl Physiol. 1972 Feb;32(2):245–251. doi: 10.1152/jappl.1972.32.2.245. [DOI] [PubMed] [Google Scholar]
  2. BERGLUND E., BIRATH G., BJURE J., GRIMBY G., KJELLMER I., SANDQVIST L., SODERHOLM B. Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand. 1963 Feb;173:185–192. [PubMed] [Google Scholar]
  3. Beaven G. H., Hornabrook R. W., Fox R. H., Huehns E. R. Occurrence of heterozygotes and homozygotes for the alpha-chain haemoglobin variant Hb-J(Tongariki) in New Guinea. Nature. 1972 Jan 7;235(5332):46–47. doi: 10.1038/235046a0. [DOI] [PubMed] [Google Scholar]
  4. Becklake M. R., Fournier-Massey G., McDonald J. C., Siemiatycki J., Rossiter C. E. Lung function in relation to chest radiographic changes in Quebec asbestos workers. I. Methods, results and conclusions. Bull Physiopathol Respir (Nancy) 1970 Jul-Sep;6(3):637–659. [PubMed] [Google Scholar]
  5. Chuan P. S., Chia M. Respiratory function tests in normal adult Chinese in Singapore. Singapore Med J. 1969 Dec;10(4):265–271. [PubMed] [Google Scholar]
  6. Cleary G. J., Blackburn R. B. Air pollution in native huts in the highlands of New Guinea. Arch Environ Health. 1968 Nov;17(5):785–794. doi: 10.1080/00039896.1968.10665320. [DOI] [PubMed] [Google Scholar]
  7. Cotes J. E., Adam J. R., Anderson H. R., Kay V. F., Patrick J. M., Saunders M. J. Lung function and exercise performance of young adult New Guineans. Hum Biol Oceania. 1972 Aug;1(4):316–317. [PubMed] [Google Scholar]
  8. Cotes J. E., Dabbs J. M., Daley C., Hall A. M., Johnson G. R., Reed J. W., Saunders M. J. Above-average exercise capacity in competition cyclists; relationship to body muscle. J Physiol. 1971 Oct;218 (Suppl):63P–64P. [PubMed] [Google Scholar]
  9. Cotes J. E., Dabbs J. M., Elwood P. C., Hall A. M., McDonald A., Saunders M. J. Iron-deficiency anaemia: its effect on transfer factor for the lung (diffusiong capacity) and ventilation and cardiac frequency during sub-maximal exercise. Clin Sci. 1972 Mar;42(3):325–335. doi: 10.1042/cs0420325. [DOI] [PubMed] [Google Scholar]
  10. Cotes J. E., Ward M. P. Ventilatory capacity in normal Bhutanese. J Physiol. 1966 Oct;186(2):88P–89P. [PMC free article] [PubMed] [Google Scholar]
  11. DeGraff A. C., Jr, Grover R. F., Johnson R. L., Jr, Hammond J. W., Jr, Miller J. M. Diffusing capacity of the lung in Caucasians native to 3,100 m. J Appl Physiol. 1970 Jul;29(1):71–76. doi: 10.1152/jappl.1970.29.1.71. [DOI] [PubMed] [Google Scholar]
  12. Dugdale A. E., Bolton J. M., Ganendran A. Respiratory function among Malaysian aboriginals. Thorax. 1971 Nov;26(6):740–743. doi: 10.1136/thx.26.6.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. GOLDMAN H. I., BECKLAKE M. R. Respiratory function tests; normal values at median altitudes and the prediction of normal results. Am Rev Tuberc. 1959 Apr;79(4):457–467. doi: 10.1164/artpd.1959.79.4.457. [DOI] [PubMed] [Google Scholar]
  14. Guleria J. S., Pande J. N., Sethi P. K., Roy S. B. Pulmonary diffusing capacity at high altitude. J Appl Physiol. 1971 Oct;31(4):536–543. doi: 10.1152/jappl.1971.31.4.536. [DOI] [PubMed] [Google Scholar]
  15. Lawther P. J., Brooks A. G., Waller R. E. Respiratory function measurements in a cohort of medical students. Thorax. 1970 Mar;25(2):172–177. doi: 10.1136/thx.25.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McDermott M., McDermott T. J., Collins M. M. A portable bellows spirometer and timing unit for the measurement of respiratory function. Med Biol Eng. 1968 Jun;6(3):291–302. doi: 10.1007/BF02478783. [DOI] [PubMed] [Google Scholar]
  17. Meade F., Saunders M. J., Hyett F., Reynolds J. A., Pearl N., Cotes J. E. Automatic measurement of lung function. Lancet. 1965 Sep 18;2(7412):573–575. doi: 10.1016/s0140-6736(65)90874-3. [DOI] [PubMed] [Google Scholar]
  18. Miller G. J., Cotes J. E., Hall A. M., Salvosa C. B., Ashworth A. Lung function and exercise performance of healthy Caribbean men and women of African ethnic origin. Q J Exp Physiol Cogn Med Sci. 1972 Jul;57(3):325–341. doi: 10.1113/expphysiol.1972.sp002166. [DOI] [PubMed] [Google Scholar]
  19. Norgan N. G., Ferro-Luzzi A., Durnin J. V. An investigation of a nutritional enigma. Studies on coastal and highland populations in New Guinea. Hum Biol Oceania. 1972 Aug;1(4):318–319. [PubMed] [Google Scholar]
  20. ROUGHTON F. J., FORSTER R. E. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J Appl Physiol. 1957 Sep;11(2):290–302. doi: 10.1152/jappl.1957.11.2.290. [DOI] [PubMed] [Google Scholar]
  21. Remmers J. E., Mithoefer J. C. The carbon monoxide diffusing capacity in permanent residents at high altitudes. Respir Physiol. 1969 Feb;6(2):233–244. doi: 10.1016/0034-5687(69)90061-9. [DOI] [PubMed] [Google Scholar]
  22. Reuschlein P. S., Reddan W. G., Burpee J., Gee J. B., Rankin J. Effect of physical training on the pulmonary diffusing capacity during submaximal work. J Appl Physiol. 1968 Feb;24(2):152–158. doi: 10.1152/jappl.1968.24.2.152. [DOI] [PubMed] [Google Scholar]
  23. SHAPIRO W., PATTERSON J. L., Jr Effects of smoking and athletic conditioning on ventilatory mechanics, including observations on the reliability of the forced expirogram. Am Rev Respir Dis. 1962 Feb;85:191–199. doi: 10.1164/arrd.1962.85.2.191. [DOI] [PubMed] [Google Scholar]
  24. Weibel E. R. Morphometric estimation of pulmonary diffusion capacity. V. Comparative morphometry of alveolar lungs. Respir Physiol. 1972 Mar;14(1):26–43. doi: 10.1016/0034-5687(72)90015-1. [DOI] [PubMed] [Google Scholar]
  25. Woolcock A. J., Blackburn C. R. Chronic lung disease in the territory of Papula and New Guinea--an epidemiological study. Australas Ann Med. 1967 Feb;16(1):11–19. doi: 10.1111/imj.1967.16.1.11. [DOI] [PubMed] [Google Scholar]
  26. Woolcock A. J., Blackburn C. R., Freeman M. H., Zylstra W., Spring S. R. Studies of chronic (nontuberculous) lung disease in New Guinea populations. The nature of the disease. Am Rev Respir Dis. 1970 Oct;102(4):575–590. doi: 10.1164/arrd.1970.102.4.575. [DOI] [PubMed] [Google Scholar]
  27. Woolcock A. J., Colman M. H., Blackburn C. R. Factors affecting normal values for ventilatory lung function. Am Rev Respir Dis. 1972 Nov;106(5):692–709. doi: 10.1164/arrd.1972.106.5.692. [DOI] [PubMed] [Google Scholar]

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