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. 1974 Sep;29(5):534–538. doi: 10.1136/thx.29.5.534

Cardiorespiratory effects of protamine after cardiopulmonary bypass in man

J Jastrzebski 1,2,3, M K Sykes 1,2,3, D G Woods 1,2,3
PMCID: PMC470194  PMID: 4428453

Abstract

Jastrzebski, J., Sykes, M. K., and Woods, D. G. (1974).Thorax, 29, 534-538. Cardiorespiratory effects of protamine after cardiopulmonary bypass in man. The cardiorespiratory changes following the injection of protamine sulphate (6 mg/kg) were studied in 15 patients who had undergone cardiopulmonary bypass. There was a transient fall in arterial pressure and a more prolonged increase in pulmonary artery pressure. There was a significant fall in arterial oxygen tension which was mainly due to a reduction in mixed venous oxygen tension resulting from a fall in cardiac output. Dead space/tidal volume ratio and percentage shunt did not change significantly.

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Selected References

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