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. 1974 Sep;29(5):571–573. doi: 10.1136/thx.29.5.571

Response of patients receiving high dose beclomethasone dipropionate

J F Costello 1,1, T J H Clark 1
PMCID: PMC470201  PMID: 4372745

Abstract

Costello, J. F. and Clark, T. J. H. (1974).Thorax, 29, 571-573. Response of patients receiving high dose beclomethasone dipropionate. Beclomethasone dipropionate was inhaled by 16 patients with asthma in a dose of 1 mg daily for periods up to 24 weeks. No evidence of adrenal suppression was found in these patients as judged by basal cortisol levels. A further group of five patients with asthma inhaled 2 mg daily of beclomethasone dipropionate for periods up to 10 weeks and no evidence of adrenal suppression was found. A separate group of five patients was found to respond to increasing doses of beclomethasone dipropionate by increasing their forced expiratory volume in the first second. The results suggest that increased doses of beclomethasone dipropionate may provide additional benefit while continuing to avoid unwanted systemic side effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown H. M., Storey G., George W. H. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J. 1972 Mar 4;1(5800):585–590. doi: 10.1136/bmj.1.5800.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Choo-Kang Y. F., Cooper E. J., Tribe A. E., Grant I. W. Beclomethasone dipropionate by inhalation in the treatment of airways obstruction. Br J Dis Chest. 1972 Apr;66(2):101–106. [PubMed] [Google Scholar]
  3. Clark T. J. Effect of beclomethasone dipropionate delivered by aerosol in patients with asthma. Lancet. 1972 Jun 24;1(7765):1361–1364. doi: 10.1016/s0140-6736(72)91094-x. [DOI] [PubMed] [Google Scholar]
  4. Gaddie J., Petrie G. R., Reid I. W., Skinner C., Sinclair D. J., Palmer K. N. Aerosol beclomethasone dipropionate: a dose-response study in chronic bronchial asthma. Lancet. 1973 Aug 11;2(7824):280–281. doi: 10.1016/s0140-6736(73)90788-5. [DOI] [PubMed] [Google Scholar]
  5. Lal S., Harris D. M., Bhalla K. K., Singhal S. N., Butler A. G. Comparison of beclomethasone dipropionate aerosol and prednisolone in reversible airways obstruction. Br Med J. 1972 Aug 5;3(5822):314–317. doi: 10.1136/bmj.3.5822.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Maberly D. J., Gibson G. J., Butler A. G. Recovery of adrenal function after substitution of beclomethasone dipropionate for oral corticosteroids. Br Med J. 1973 Mar 31;1(5856):778–779. doi: 10.1136/bmj.1.5856.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. WOOD J. B., FRANKLAND A. W., JAMES V. H., LANDON J. A RAPID TEST OF ADRENOCORTICAL FUNCTION. Lancet. 1965 Jan 30;1(7379):243–245. doi: 10.1016/s0140-6736(65)91526-6. [DOI] [PubMed] [Google Scholar]

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