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. 1975 Aug;30(4):430–435. doi: 10.1136/thx.30.4.430

Interaction of corticosteroids and catecholamines in the treatment of asthma.

G M Shenfield, M E Hodson, S W Clarke, J W Paterson
PMCID: PMC470304  PMID: 1179326

Abstract

Twelve patients with airways obstruction (due to asthma and/or chronic bronchitis) were given a trial of prednisone therapy to assess reversibility. Six asthmatic patients responded well but no predictive criteria were found. In three patients improvement in forced expiratory volume in 1 second (FEV1) was detectable at 6 hours but not at 3 hours. One patient took 36 hours to show any sign of improvement. None of the patients who improved reached their peak FEV1 before six days treatment with prednisone, which suggests that a 'trial of steroids' should last for at least one week. Potentiation, as measured by either a greater peak rise or a more sustained increase in FEV1 after isoprenaline, was observed in five of the six asthmatic patients responding to steroids. It is concluded that potentiation of catecholmines is one of the mechanisms by which corticosteroids may act in asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altura B. M. Role of glucocorticoids in local regulation of blood flow. Am J Physiol. 1966 Dec;211(6):1393–1397. doi: 10.1152/ajplegacy.1966.211.6.1393. [DOI] [PubMed] [Google Scholar]
  2. Andersson R., Bergh N. P., Svedmyr N. Metabolic actions in human bronchial muscle associated with ACTH induced relaxation. Scand J Respir Dis. 1972;53(2):125–128. [PubMed] [Google Scholar]
  3. Aviado D. M., Carrillo L. R. Antiasthmatic action of corticosteroids: a review of the literature on their mechanism of action. J Clin Pharmacol J New Drugs. 1970 Jan-Feb;10(1):3–11. [PubMed] [Google Scholar]
  4. Aviado D. M., Carrillo L. R. Hormones and pulmonary effects of tobacco. I. Corticosteroids and their antiasthmatic action. Arch Environ Health. 1969 Jun;18(6):925–933. doi: 10.1080/00039896.1969.10665516. [DOI] [PubMed] [Google Scholar]
  5. Bass H. Endogenous regulation of the pulmonary response to isoproterenol. Chest. 1972 Jan;61(1):14–17. doi: 10.1378/chest.61.1.14. [DOI] [PubMed] [Google Scholar]
  6. Baxter J. D., Forsham P. H. Tissue effects of glucocorticoids. Am J Med. 1972 Nov;53(5):573–589. doi: 10.1016/0002-9343(72)90154-4. [DOI] [PubMed] [Google Scholar]
  7. Breckenridge B. M. Cyclic AMP and drug action. Annu Rev Pharmacol. 1970;10:19–34. doi: 10.1146/annurev.pa.10.040170.000315. [DOI] [PubMed] [Google Scholar]
  8. CARRYER H. M., KOELSCHE G. A., PRICKMAN L. E., MAYTUM C. K., LAKE C. F., WILLIAMS H. L. Effects of cortisone on bronchial asthma and hay fever occurring in subjects sensitive to ragweed pollen. Proc Staff Meet Mayo Clin. 1950 Aug 16;25(17):482–486. [PubMed] [Google Scholar]
  9. Carrillo L. R., Aviado D. M. Mechanisms for the bronchodilator effects of corticosteroids in the sensitized rabbit. J Pharmacol Exp Ther. 1968 Dec;164(2):302–311. [PubMed] [Google Scholar]
  10. Ellul-Micallef R., Borthwick R. C., McHardy G. J. Time course of response to corticosteroids in chronic bronchial asthma. Clin Sci. 1972 Dec;43(6):15P–15P. doi: 10.1042/cs043015pa. [DOI] [PubMed] [Google Scholar]
  11. FLANAGAN E. G., PEMBERTON J. Vital capacity and timed vital capacity in normal men over forty. J Appl Physiol. 1956 Sep;9(2):291–296. doi: 10.1152/jappl.1956.9.2.291. [DOI] [PubMed] [Google Scholar]
  12. FOWLER N. O., CHOU N. H. Potentiation of smooth muscle contraction by adrenal steroids. Circ Res. 1961 Jan;9:153–156. doi: 10.1161/01.res.9.1.153. [DOI] [PubMed] [Google Scholar]
  13. FRANKLIN W., MICHELSON A. L., LOWELL F. C., SCHILLER I. W. Bronchodilators and corticosteroids in the treatment of obstructive pulmonary emphysema. N Engl J Med. 1958 Apr 17;258(16):774–778. doi: 10.1056/NEJM195804172581602. [DOI] [PubMed] [Google Scholar]
  14. Feldman D., Funder J. W., Edelman I. S. Subcellular mechanisms in the action of adrenal steroids. Am J Med. 1972 Nov;53(5):545–560. doi: 10.1016/0002-9343(72)90152-0. [DOI] [PubMed] [Google Scholar]
  15. Freedman S., Prowse K. How many blows make an F.E.V.1.0? Lancet. 1966 Sep 17;2(7464):618–619. doi: 10.1016/s0140-6736(66)91928-3. [DOI] [PubMed] [Google Scholar]
  16. Geddes B. A., Lefcoe N. M. Respiratory smooth muscle relaxing effect of commercial steroid preparations. Am Rev Respir Dis. 1973 Mar;107(3):395–399. doi: 10.1164/arrd.1973.107.3.395. [DOI] [PubMed] [Google Scholar]
  17. Gillespie J. S. Uptake of noradrenaline by smooth muscle. Br Med Bull. 1973 May;29(2):136–141. doi: 10.1093/oxfordjournals.bmb.a070983. [DOI] [PubMed] [Google Scholar]
  18. Gregg I. Reversibility of airways obstruction in asthma. Respiration. 1969;26(Suppl):123–130. doi: 10.1159/000192646. [DOI] [PubMed] [Google Scholar]
  19. Kalsner S. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta. Circ Res. 1969 Mar;24(3):383–395. doi: 10.1161/01.res.24.3.383. [DOI] [PubMed] [Google Scholar]
  20. LEFCOE N. M. The effect of hydrocortisone hemisuccinate on tracheal smooth muscle of the guinea pig and cat. J Allergy. 1956 Jul;27(4):352–358. doi: 10.1016/0021-8707(56)90074-0. [DOI] [PubMed] [Google Scholar]
  21. LUKAS D. S. Some effects of adrenocorticotropic hormone and cortisone on pulmonary function of patients with obstructive emphysema. Am Rev Tuberc. 1951 Sep;64(3):279–294. doi: 10.1164/art.1951.64.3.279. [DOI] [PubMed] [Google Scholar]
  22. MENDLOWITZ M., GITLOW S., NAFTCHI N. Work of digital vasoconstriction produced by infused norepinephrine in Cushing's syndrome. J Appl Physiol. 1958 Sep;13(2):252–256. doi: 10.1152/jappl.1958.13.2.252. [DOI] [PubMed] [Google Scholar]
  23. NASMYTH P. A. The effect of corticosteroids on the isolated mammalian heart and its response to adrenaline. J Physiol. 1957 Dec 31;139(3):323–336. doi: 10.1113/jphysiol.1957.sp005894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. SCHAYER R. W. A UNIFIED THEORY OF GLUCOCORTICOID ACTION. Perspect Biol Med. 1964;7:71–84. doi: 10.1353/pbm.1964.0006. [DOI] [PubMed] [Google Scholar]

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