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. 1972 Sep;27(5):604–610. doi: 10.1136/thx.27.5.604

Two unusual organisms, Aspergillus terreus and Metschnikowia pulcherrima, associated with the lung disease of ankylosing spondylitis

W P U Kennedy 1, L J R Milne 2, W Blyth 3, G K Crompton 1
PMCID: PMC470565  PMID: 4628429

Abstract

Two male patients with ankylosing spondylitis and upper lobe fibrosis and cavitation are described. A pneumonic disease in one was associated with mycological and serological evidence of infection with Aspergillus terreus but no other aspergillus species. A large pulmonary mycetoma developed in the second patient and among a number of other fungal isolates was found the yeast Metschnikowia pulcherrima. The association of ankylosing spondylitis with bronchopulmonary aspergillosis is considered; A. terreus is described for the first time as a human pulmonary pathogen, and the possible pathogenicity of M. pulcherrima in the debilitated human subject is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adelson H. T., Malcolm J. A. Endocavitary treatment of pulmonary mycetomas. Am Rev Respir Dis. 1968 Jul;98(1):87–92. doi: 10.1164/arrd.1968.98.1.87. [DOI] [PubMed] [Google Scholar]
  2. CAMPBELL M. J., CLAYTON Y. M. BRONCHOPULMONARY ASPERGILLOSIS. A CORRELATION OF THE CLINICAL AND LABORATORY FINDINGS IN 272 PATIENTS INVESTIGATED FOR BRONCHOPULMONARY ASPERGILLOSIS. Am Rev Respir Dis. 1964 Feb;89:186–196. doi: 10.1164/arrd.1964.89.2.186. [DOI] [PubMed] [Google Scholar]
  3. DAVIS C. L., SCHAEFER W. B. Cutaneous aspergillosis in a cow. J Am Vet Med Assoc. 1962 Dec 1;141:1339–1343. [PubMed] [Google Scholar]
  4. Davies D. Lung fibrosis and cavitation mimicking tuberculosis. Tubercle. 1970 Sep;51(3):246–254. doi: 10.1016/0041-3879(70)90016-4. [DOI] [PubMed] [Google Scholar]
  5. EDWARDS G., LATOUCHE C. J. THE TREATMENT OF BRONCHOPULMONARY MYCOSES WITH A NEW ANTIBIOTIC--PIMARICIN. Lancet. 1964 Jun 20;1(7347):1349–1353. doi: 10.1016/s0140-6736(64)92038-0. [DOI] [PubMed] [Google Scholar]
  6. GROCOTT R. G. A stain for fungi in tissue sections and smears using Gomori's methenamine-silver nitrate technic. Am J Clin Pathol. 1955 Aug;25(8):975–979. doi: 10.1093/ajcp/25.8_ts.0975. [DOI] [PubMed] [Google Scholar]
  7. LONGBOTTOM J. L., PEPYS J. PULMONARY ASPERGILLOSIS: DIAGNOSTIC AND IMMUNOLOGICAL SIGNIFICANCE OF ANTIGENS AND C-SUBSTANCE IN ASPERGILLUS FUMIGATUS. J Pathol Bacteriol. 1964 Jul;88:141–151. doi: 10.1002/path.1700880119. [DOI] [PubMed] [Google Scholar]
  8. Leggat P. O., De Kretser D. M. Aspergillus pneumonia in association with an aspergilloma. Br J Dis Chest. 1968 Jul;62(3):147–150. doi: 10.1016/s0007-0971(68)80005-1. [DOI] [PubMed] [Google Scholar]
  9. Mahgoub el-S, Ismail S. A., el-Hassan A. M. Cervical lymphadenopathy caused by Aspergillus terreus. Br Med J. 1969 Mar 15;1(5645):689–690. doi: 10.1136/bmj.1.5645.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pore R. S., Larsh H. W. Experimental pathology of Aspergillus terreus-flavipes group species. Sabouraudia. 1968 Feb;6(2):89–93. [PubMed] [Google Scholar]

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