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. 1977 Apr;32(2):194–197. doi: 10.1136/thx.32.2.194

Effect of lung function and mode of inhalation on penetration of aerosol into the human lung.

D Pavia, M L Thomson, S W Clarke, H S Shannon
PMCID: PMC470568  PMID: 867333

Abstract

The method using radioactive tracer particles has been applied to study the effect of the mode of inhalation of aerosols on the depth of deposition in the lungs of 50 patients with airways obstruction. The findings show that the penetration of particles is directly related to: (1) volume inspired per breath (VI); (2) forced expiratory volume in one second (FEV1); and inversely related to (3) flow rate during inhalation (V). In mathematical terms, alveolar deposition (%) = 40-3 (VI)+10-98 (FEV1)--0-75 (V)+40-4; for this regression F = 4-41 and P less than 0-01.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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