Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1972 Sep;27(5):620–624. doi: 10.1136/thx.27.5.620

Primary diffuse tracheobronchial amyloidosis

H D Attwood 1,2, C G Price 1,2, R J Riddell 1,2
PMCID: PMC470570  PMID: 5083730

Abstract

The case is reported of a woman who died at the age of 36 years from obstructive respiratory failure due to diffuse tracheobronchial amyloidosis which had caused symptoms for six years. When first seen her symptoms of wheezing cough and mucopurulent sputum sometimes streaked with blood were of recent onset, but on bronchogram and bronchoscopy her disease was already widespread. Appearances at bronchography were interpreted as malformation and at bronchoscopy as tracheobronchitis, possibly tuberculous. Bronchoscopic biopsy was necessary to make the diagnosis of amyloidosis. The amyloid gave the usual staining reactions with an apple-green birefringence in polarized light following staining with Congo red. At necropsy an extensive histological survey proved that the amyloid was confined to the trachea and main stem bronchi. There was no associated disease, no family history, and no upset in plasma proteins.

Full text

PDF
622

Images in this article

620Image
on p.620
621Image
on p.621
621Image
on p.621
622Image
on p.622
622Image
on p.622

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Antunes M. L., Vieira da Luz J. M. Primary diffuse tracheo-bronchial amyloidosis. Thorax. 1969 May;24(3):307–311. doi: 10.1136/thx.24.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beck O. A. Diffuse alveolarseptale Lungenamyloidose. Virchows Arch A Pathol Pathol Anat. 1970;350(4):336–352. [PubMed] [Google Scholar]
  3. Cathcart E. S., Mullarkey M., Cohen A. S. Amyloidosis: an expression of immunological tolerance? Lancet. 1970 Sep 26;2(7674):639–640. doi: 10.1016/s0140-6736(70)91403-0. [DOI] [PubMed] [Google Scholar]
  4. Chaudhuri M. R., Parker D. J. A solitary amyloid nodule in the lung. Thorax. 1970 May;25(3):382–386. doi: 10.1136/thx.25.3.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DOOD A. R., MANN J. D. Primary diffuse amyloidosis of the respiratory tract. AMA Arch Pathol. 1959 Jan;67(1):39–42. [PubMed] [Google Scholar]
  6. González-Cueto D. M., Rigoli M., Gioseffi L. M., Lancelle B., Martínez A. Diffuse pulmonary amyloidosis. Am J Med. 1970 May;48(5):668–670. doi: 10.1016/0002-9343(70)90020-3. [DOI] [PubMed] [Google Scholar]
  7. Mainwaring A. R., Williams G., Knight E. O., Bassett H. F. Localized amyloidosis of the lower respiratory tract. Thorax. 1969 Jul;24(4):441–445. doi: 10.1136/thx.24.4.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. NORING O., PAABY H. Diffuse amyloidosis in the lower air passages; report of a case. Acta Pathol Microbiol Scand. 1952;31(4):470–475. doi: 10.1111/j.1699-0463.1952.tb00215.x. [DOI] [PubMed] [Google Scholar]
  9. PROWSE C. B. Amyloidosis of the lower respiratory tract. Thorax. 1958 Dec;13(4):308–320. doi: 10.1136/thx.13.4.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. PROWSE C. B., ELLIOTT R. I. DIFFUSE TRACHEO-BRONCHIAL AMYLOIDOSIS: A RARE VARIANT OF A PROTEAN DISEASE. Thorax. 1963 Dec;18:326–333. doi: 10.1136/thx.18.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SYMMERS W. S. Primary amyloidosis: a review. J Clin Pathol. 1956 Aug;9(3):187–211. doi: 10.1136/jcp.9.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Zundel W. E., Prior A. P. An amyloid lung. Thorax. 1971 May;26(3):357–363. doi: 10.1136/thx.26.3.357. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES