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. 1978 Feb;33(1):89–93. doi: 10.1136/thx.33.1.89

Cyclophosphamide pneumonitis.

G J Mark, A Lehimgar-Zadeh, B D Ragsdale
PMCID: PMC470852  PMID: 644545

Abstract

Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis. Although it has been reported previously in patients being treated for lymphoma, it occurred in this case in a man under treatment for glomerulonephritis. The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease. There may be an interval of one or more months after discontinuation of cyclophosphamide therapy before clinical or radiological improvement occurs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. André R., Rochant H., Dreyfus B., Duhamel G., Péchère J. C. Fibrose interstitielle diffuse du poumon au cours d'une maladie de Hodgkin traitée par des doses élevées d'endoxan. Bull Mem Soc Med Hop Paris. 1967 Nov 3;118(12):1133–1141. [PubMed] [Google Scholar]
  2. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1972. N Engl J Med. 1972 Jun 29;286(26):1405–1411. doi: 10.1056/NEJM197206292862611. [DOI] [PubMed] [Google Scholar]
  3. Dohner V. A., Ward H. P., Standord R. E. Alveolitis during procarbazine, vincristine and cyclophosphamide therapy. Chest. 1972 Nov;62(5):636–639. doi: 10.1378/chest.62.5.636. [DOI] [PubMed] [Google Scholar]
  4. Karnofsky D. A. Symposium on immunosuppressive drugs. Late effects of immunosuppressive anticancer drugs. Fed Proc. 1967 May-Jun;26(3):925–933. [PubMed] [Google Scholar]
  5. Maxwell I. Letter: Reversible pulmonary edema following cyclophosphamide treatment. JAMA. 1974 Jul 8;229(2):137–138. doi: 10.1001/jama.1974.03230400013005. [DOI] [PubMed] [Google Scholar]
  6. Meschan I., DeArmas C. R., Scharyj M. Adult bronchopulmonary dysplasia: the similarity in roentgen and histopathologic appearance between some cases of oxygen toxicity, radiation pneumonitis, and postcytotoxic nonspecific bronchopneumonia. Radiology. 1969 Mar;92(3):612–615. doi: 10.1148/92.3.612. [DOI] [PubMed] [Google Scholar]
  7. Patel A. R., Shah P. C., Rhee H. L., Sassoon H., Rao K. P. Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer. 1976 Oct;38(4):1542–1549. doi: 10.1002/1097-0142(197610)38:4<1542::aid-cncr2820380416>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  8. Rodin A. E., Haggard M. E., Travis L. B. Lung changes and chemotherapeutic agents in childhood. Report of a case associated with cyclophosphamide therapy. Am J Dis Child. 1970 Oct;120(4):337–340. doi: 10.1001/archpedi.1970.02100090111012. [DOI] [PubMed] [Google Scholar]
  9. Rosenow E. C., 3rd The spectrum of drug-induced pulmonary disease. Ann Intern Med. 1972 Dec;77(6):977–991. doi: 10.7326/0003-4819-77-6-977. [DOI] [PubMed] [Google Scholar]
  10. Stutz F. H., Tormey D. C., Blom J. Nonbacterial pneumonitis with multidrug antineoplastic therapy in breast carcinoma. Can Med Assoc J. 1973 Mar 17;108(6):710–714. [PMC free article] [PubMed] [Google Scholar]
  11. Topilow A. A., Rothenberg S. P., Cottrell T. S. Interstitial pneumonia after prolonged treatment with cyclophosphamide. Am Rev Respir Dis. 1973 Jul;108(1):114–117. doi: 10.1164/arrd.1973.108.1.114. [DOI] [PubMed] [Google Scholar]

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