Abstract
The oral administration of Crotalaria spectabilis seeds to young rats induces pulmonary hypertension in them associated with right ventricular hypertrophy and an increase in the medial thickness of the pulmonary trunk and muscular pulmonary arteries. This appears to be the first direct demonstration that the oral administration of an agent may bring about pulmonary hypertension.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARNES J. M., MAGEE P. N., SCHOENTAL R. LESIONS IN THE LUNGS AND LIVERS OF RATS POISONED WITH THE PYRROLIZIDINE ALKALOID FULVINE AND ITS N-OXIDE. J Pathol Bacteriol. 1964 Oct;88:521–531. doi: 10.1002/path.1700880215. [DOI] [PubMed] [Google Scholar]
- Heath D., Kay J. M. Medical thickness of pulmonary trunk in rats with cor pulmonale induced by ingestion of Crotalaria spectabilis seeds. Cardiovasc Res. 1967 Jan;1(1):74–79. doi: 10.1093/cvr/1.1.74. [DOI] [PubMed] [Google Scholar]
- LALICH J. J., EHRHART L. A. Monocrotaline-induced pulmonary arteritis in rats. J Atheroscler Res. 1962 Nov-Dec;2:482–492. doi: 10.1016/s0368-1319(62)80020-9. [DOI] [PubMed] [Google Scholar]
- LALICH J. J., MERKOW L. Pulmonary arteritis produced in rat by feeding Crotalaria spectabilis. Lab Invest. 1961 Jul-Aug;10:744–750. [PubMed] [Google Scholar]
- Merkow L., Kleinerman J. An electron microscopic study of pulmonary vasculitis induced by monocrotaline. Lab Invest. 1966 Mar;15(3):547–564. [PubMed] [Google Scholar]
- TAKEOKA O., ANGEVINE D. M., LALICH J. J. Stimulation of mast cells in rats fed various chemicals. Am J Pathol. 1962 May;40:545–554. [PMC free article] [PubMed] [Google Scholar]
- TURNER J. H., LALICH J. J. EXPERIMENTAL COR PULMONALE IN THE RAT. Arch Pathol. 1965 Apr;79:409–418. [PubMed] [Google Scholar]