Abstract
In order to determine the effect of drugs on bronchial hyperreactivity in subjects with asthma, 12 atopic asthmatic volunteers underwent bronchial challenge with either histamine or methacholine on three separate days. Before the challenges no medication was given on the first day, on the second 400 microgram of aerosol fenoterol and on the third 5 mg of oral fenoterol were administered. The aerosol fenoterol caused the dose response curves to both histamine and methacholine to be shifted to the right in all subjects. The oral dose produced no significant change from the control values. The slope of the dose response curves was not altered by either the oral or the aerosol drug. It is concluded that aerosol but not oral fenoterol in the clinical dosage, causes a change in the sensitivity but not in the reactivity of the airway of patients with atopic asthma.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson S. D., Rozea P. J., Dolton R., Lindsay D. A. Inhaled and oral bronchodilator therapy in exercise induced asthma. Aust N Z J Med. 1975 Dec;5(6):544–550. doi: 10.1111/j.1445-5994.1975.tb03860.x. [DOI] [PubMed] [Google Scholar]
- Anderson S. D., Seale J. P., Rozea P., Bandler L., Theobald G., Lindsay D. A. Inhaled and oral salbutamol in exercise-induced asthma. Am Rev Respir Dis. 1976 Sep;114(3):493–500. doi: 10.1164/arrd.1976.114.3.493. [DOI] [PubMed] [Google Scholar]
- Chai H., Farr R. S., Froehlich L. A., Mathison D. A., McLean J. A., Rosenthal R. R., Sheffer A. L., Spector S. L., Townley R. G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. doi: 10.1016/0091-6749(75)90107-4. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Protective effect of drugs on histamine-induced asthma. Thorax. 1977 Aug;32(4):429–437. doi: 10.1136/thx.32.4.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Juniper E. F., Frith P. A., Dunnett C., Cockcroft D. W., Hargreave F. E. Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax. 1978 Dec;33(6):705–710. doi: 10.1136/thx.33.6.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris J. F., Koski A., Johnson L. C. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis. 1971 Jan;103(1):57–67. doi: 10.1164/arrd.1971.103.1.57. [DOI] [PubMed] [Google Scholar]
- Orehek J., Gayrard P., Smith A. P., Grimaud C., Charpin J. Airway response to carbachol in normal and asthmatic subjects: distinction between bronchial sensitivity and reactivity. Am Rev Respir Dis. 1977 Jun;115(6):937–943. doi: 10.1164/arrd.1977.115.6.937. [DOI] [PubMed] [Google Scholar]
- VanArsdel P. P., Jr, Schaffrin R. M., Rosenblatt J., Sprenkle A. C., Altman L. C. Evaluation of oral fenoterol in chronic asthmatic patients. Chest. 1978 Jun;73(6 Suppl):997–998. doi: 10.1378/chest.73.6_supplement.997. [DOI] [PubMed] [Google Scholar]