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. 1970 Jan;25(1):110–115. doi: 10.1136/thx.25.1.110

Phagocytic potential of pulmonary alveolar epithelium with particular reference to surfactant metabolism

B Corrin 1
PMCID: PMC472132  PMID: 5418003

Abstract

Finely divided thorium and carbon were injected into the rat lung via the trachea and their uptake was studied electron microscopically. Small amounts of thorium were found in the lamellar vacuoles of the granular pneumocytes. Their presence was maximal at 24 hours and they later disappeared from these cells. This phenomenon is thought to represent a passive inflow as the vacuoles open on to the alveolar surface to discharge their content of surfactant, rather than evidence that the granular pneumocyte is concerned in surfactant disposal. An explanation reconciling the secretory nature of the vacuoles with their previously demonstrated content of lysosomal enzymes is advanced. Small quantities of thorium dioxide were ingested by the squamous pneumocytes and a little transferred to interstitial macrophages, but this is a minor route of disposal, the bulk of the material being ingested by alveolar macrophages. The limited phagocytic potential of the alveolar epithelium contrasts with that of the alveolar macrophages and is not taken to support the concept of an epithelial derivation of alveolar macrophages.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Azzopardi A., Thurlbeck W. M. The histochemistry of the nonciliated bronchiolar epithelial cell. Am Rev Respir Dis. 1969 Apr;99(4):516–525. doi: 10.1164/arrd.1969.99.4P1.516. [DOI] [PubMed] [Google Scholar]
  2. BENSCH K., SCHAEFER K., AVERY M. E. GRANULAR PNEUMOCYTES: ELECTRON MICROSCOPIC EVIDENCE OF THEIR EXOCRINIC FUNCTION. Science. 1964 Sep 18;145(3638):1318–1319. doi: 10.1126/science.145.3638.1318-a. [DOI] [PubMed] [Google Scholar]
  3. BUCKINGHAM S., AVERY M. E. Time of appearance of lung surfactant in the foetal mouse. Nature. 1962 Feb 17;193:688–689. doi: 10.1038/193688a0. [DOI] [PubMed] [Google Scholar]
  4. Buckingham S., Heinemann H. O., Sommers S. C., McNary W. F. Phospholipid synthesis in the large pulmonary alveolar cell. Its relation to lung surfactants. Am J Pathol. 1966 Jun;48(6):1027–1041. [PMC free article] [PubMed] [Google Scholar]
  5. Choy A. E., Cravioto H. A study of aryl sulfatase and acid phosphatase in the developing nervous system of the rat. J Histochem Cytochem. 1968 Sep;16(9):582–589. doi: 10.1177/16.9.582. [DOI] [PubMed] [Google Scholar]
  6. Corrin B., Clark A. E. Lysosomal aryl sulphatase in pulmonary alveolar cells. Histochemie. 1968;15(2):95–98. doi: 10.1007/BF00306361. [DOI] [PubMed] [Google Scholar]
  7. Faulkner C. S., 2nd The role of the granular pneumonocyte in surfactant metabolism an autoradiographic study. Arch Pathol. 1969 May;87(5):521–525. [PubMed] [Google Scholar]
  8. Goldenberg V. E., Buckingham S., Sommers S. C. Pilocarpine stimulation of granular pneumocyte secretion. Lab Invest. 1969 Feb;20(2):147–158. [PubMed] [Google Scholar]
  9. KARRER H. E. The ultrastructure of mouse lung: the alveolar macrophage. J Biophys Biochem Cytol. 1958 Nov 25;4(6):693–700. doi: 10.1083/jcb.4.6.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KING E. J., HARRISON C. V., MOHANTY G. P., YOGANATHAN M. The effect of aluminium and of aluminium containing 5 per cent. of quartz in the lungs of rats. J Pathol Bacteriol. 1958 Apr;75(2):429–434. doi: 10.1002/path.1700750222. [DOI] [PubMed] [Google Scholar]
  11. KLAUS M., REISS O. K., TO OLEY W. H., PIEL C., CLEMENTS J. A. Alveolar epithelial cell mitochondria as source of the surface-active lung lining. Science. 1962 Sep 7;137(3532):750–751. doi: 10.1126/science.137.3532.750. [DOI] [PubMed] [Google Scholar]
  12. Kluge T., Hovig T. Ultrastructural localization of thorotrast in the reticuloendothelial system. Am J Pathol. 1969 Mar;54(3):355–371. [PMC free article] [PubMed] [Google Scholar]
  13. Niden A. H. Bronchiolar and large alveolar cell in pulmonary phospholipid metabolism. Science. 1967 Dec 8;158(3806):1323–1324. doi: 10.1126/science.158.3806.1323. [DOI] [PubMed] [Google Scholar]
  14. POLICARD A., COLLET A., PREGERMAIN S. Etude au microscope électronique du granulome pulmonaire silicotique expérimental. Presse Med. 1957 Jan 23;65(7):121–124. [PubMed] [Google Scholar]
  15. Sorokin S P. A morphologic and cytochemical study on the great alveolar cell. J Histochem Cytochem. 1966 Dec;14(12):884–897. doi: 10.1177/14.12.884. [DOI] [PubMed] [Google Scholar]

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