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. 1965 Mar;18(2):150–156. doi: 10.1136/jcp.18.2.150

Systemic Weber-Christian disease

R D G Milner 1,2,1, M J Mitchinson 1,2
PMCID: PMC472856  PMID: 14276147

Abstract

A patient suffering from Weber-Christian panniculitis was found at necropsy to have similar lesions in the visceral adipose tissue. When the lesions occur internally, diagnosis during life is complicated by the difficulty of examining visceral adipose tissue and the disease may often go unrecognized, but patients suffering from Weber-Christian panniculitis should be investigated bearing in mind the possibility of internal lesions. Only 11 cases confirmed by necropsy appear to have been reported hitherto. The aetiology remains obscure. It is suggested that the name `systemic Weber-Christian disease' be applied when the lesions occur in adipose tissue other than the panniculus adiposus and that the term `Weber-Christian panniculitis' be used when the lesions are confined to the subcutaneous adipose tissue.

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Selected References

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  1. ARNOLD H. A., BAINBOROUGH A. R. WEBER-CHRISTIAN DISEASE WITH VISCERAL INVOLVEMENT; CASE REPORT AND REVIEW OF THE LITERATURE. Can Med Assoc J. 1963 Nov 30;89:1138–1142. [PMC free article] [PubMed] [Google Scholar]
  2. BEERMAN H. Weber-Christian syndrome. Am J Med Sci. 1953 Apr;225(4):446–462. [PubMed] [Google Scholar]
  3. CRANE J. T., AGUILAR M. J., GRIMES O. F. Isolated lipodystrophy, a form of mesenteric tumor. Am J Surg. 1955 Aug;90(2):169–179. doi: 10.1016/0002-9610(55)90748-0. [DOI] [PubMed] [Google Scholar]
  4. DELOR C. J., MARTZ R. W. Weber-Christian disease with bone involvement. Ann Intern Med. 1955 Sep;43(3):591–598. doi: 10.7326/0003-4819-43-3-591. [DOI] [PubMed] [Google Scholar]
  5. HALLAHAN J. D., KLEIN T. Relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); review of literature and report of case. Ann Intern Med. 1951 May;34(5):1179–1201. doi: 10.7326/0003-4819-34-5-1179. [DOI] [PubMed] [Google Scholar]
  6. HANRAHAN F. R., Jr, IPPOLITO V., DILWORTH R. W. Weber-Christian disease: Report of two cases, one with autopsy. Ohio State Med J. 1951 May;47(5):427–429. [PubMed] [Google Scholar]
  7. HAUGE B. N., CHRISTIANSEN T. Weber-Christian's disease: a survey with report of a case. Acta Med Scand. 1954;150(3):193–198. [PubMed] [Google Scholar]
  8. HERRINGTON J. L., Jr, EDWARDS W. H., GROSSMAN L. A. Mesenteric manifestations of Weber-Christian disease. Ann Surg. 1961 Dec;154:949–955. [PMC free article] [PubMed] [Google Scholar]
  9. HUTT M. S., PINNIGER J. L. Adrenal failure due to bilateral suprarenal infarction associated with systemic nodular panniculitis and endarteritis. J Clin Pathol. 1956 Nov;9(4):316–322. doi: 10.1136/jcp.9.4.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MACDONALD H. R. Weber-Christian disease: relapsing febrile nodular non-suppurative panniculitis. Br J Clin Pract. 1957 Apr;11(4):264–266. [PubMed] [Google Scholar]
  11. RICCI C., MICHELETTI P. C., COSCIA G. C. [Immuno-protein research in the Weber-Christian syndrome]. Minerva Med. 1961 Oct 27;52:3725–3728. [PubMed] [Google Scholar]
  12. RITAMA V., KRUSIUS F. E. [Generalised lipogranulomatosis (Weber-Christian syndrome); report of a case with autopsy]. Ann Med Intern Fenn. 1953;42(2):133–148. [PubMed] [Google Scholar]
  13. ROGERS C. E., DEMETRAKOPOULOS N. J., HYAMNS V. Isolated lipodystrophy affecting the mesentery, the retroperitoneal area and the small intestine. Ann Surg. 1961 Feb;153:277–282. doi: 10.1097/00000658-196115320-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SCHOEN I., REINGOLD I. M., MEISTER L. Relapsing nodular nonsuppurative panniculitis with lung involvement: clinical and autopsy findings, with notes on pathogenesis. Ann Intern Med. 1958 Sep;49(3):687–698. doi: 10.7326/0003-4819-49-3-687. [DOI] [PubMed] [Google Scholar]
  15. SHUMAN C. R. Relapsing panniculitis (Weber-Christian disease); review of literature and report of a case including treatment with cortisone. AMA Arch Intern Med. 1951 May;87(5):669–681. doi: 10.1001/archinte.1951.03810050045005. [DOI] [PubMed] [Google Scholar]
  16. STEINBERG B. Systemic nodular panniculitis. Am J Pathol. 1953 Nov-Dec;29(6):1059–1081. [PMC free article] [PubMed] [Google Scholar]
  17. Spain D. M., Foley J. M. Nonsuppurative Nodular Panniculitis (Weber-Christian's Disease). Am J Pathol. 1944 Jul;20(4):783–787. [PMC free article] [PubMed] [Google Scholar]
  18. TEDESCHI C. G., BOTTA G. C. Retractile mesenteritis. N Engl J Med. 1962 May 17;266:1035–1040. doi: 10.1056/NEJM196205172662005. [DOI] [PubMed] [Google Scholar]

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