Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1966 Jan;19(1):29–32. doi: 10.1136/jcp.19.1.29

Folic acid deficiency in leukaemia and lymphomas

D P Rose 1
PMCID: PMC473153  PMID: 5904978

Abstract

Serum folic acid levels and the urinary excretion of Figlu have been studied in patients with leukaemia or lymphomas. The results indicate that folic acid deficiency is a common complication of these diseases. Bone marrow examinations of those with evidence of such a deficiency frequently show megaloblastic erythropoiesis.

The Figlu test appears to be a useful screening test for folic acid deficiency in patients with leukaemia or lymphomas.

Full text

PDF
30

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DYMOCK I. W. ABNORMAL URINARY EXCRETION OF UROCANIC ACID AND FORMIMINOGLUTAMIC ACID IN NEOPLASTIC DISEASE. Lancet. 1964 Jul 18;2(7351):114–115. doi: 10.1016/s0140-6736(64)90123-0. [DOI] [PubMed] [Google Scholar]
  2. GIRDWOOD R. H. Folic-acid-excretion studies in the investigation of malignant disease. Br Med J. 1953 Oct 3;2(4839):741–745. doi: 10.1136/bmj.2.4839.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HOGAN J. A., MANIATIS A., MOLONEY W. C. THE SERUM LACTOBACILLUS CASEI FOLATE CLEARANCE TEST IN VARIOUS HEMATOLOGIC DISORDERS. Blood. 1964 Aug;24:187–197. [PubMed] [Google Scholar]
  4. KERSHAW P. W., GIRDWOOD R. H. SOME INVESTIGATIONS OF FOLIC-ACID DEFICIENCY. Scott Med J. 1964 May;9:201–212. doi: 10.1177/003693306400900503. [DOI] [PubMed] [Google Scholar]
  5. KOHN J., MOLLIN D. L., ROSENBACH L. M. Conventional voltage electrophoresis for formiminoglutamic-acid determination in folic acid deficiency. J Clin Pathol. 1961 Jul;14:345–350. doi: 10.1136/jcp.14.4.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. PITNEY W. R., JOSKE R. A., MACKINNON N. L. Folic acid and other absorption tests in lymphosarcoma, chronic lymphocytic leukaemia, and some related conditions. J Clin Pathol. 1960 Sep;13:440–447. doi: 10.1136/jcp.13.5.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. RAO PBR, LAGERLOF B., EINHORN J., REIZENSTEIN P. Low serum-folic-acid in malignancy. Lancet. 1963 Jun 1;1(7292):1192–1193. doi: 10.1016/s0140-6736(63)92487-5. [DOI] [PubMed] [Google Scholar]
  8. REISNER E. H., Jr The nature and significance of megaloblastic blood formation. Blood. 1958 Apr;13(4):313–338. [PubMed] [Google Scholar]
  9. SWENDSEID M. E., BETHELL F. H., BIRD O. D. The concentration of folic acid in leukocytes; observations on normal subjects and persons with leukemia. Cancer Res. 1951 Nov;11(11):864–867. [PubMed] [Google Scholar]
  10. SWENDSEID M. E., SWANSON A. L., MEYERS M. C., BETHELL F. H. The nutritional status of folic acid in persons with leukemia and its possible relation to effects of aminopterin therapy. Blood. 1952 Mar;7(3):307–310. [PubMed] [Google Scholar]
  11. VILLAMIL A., McCRACKEN B. H. Clinical usefulness of urinary Figlu test in megaloblastic anaemias. Br Med J. 1963 Mar 16;1(5332):717–720. doi: 10.1136/bmj.1.5332.717. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES