Abstract
Plasma fibrinogen and plasminogen levels were measured in 122 male and 56 female healthy adult subjects and in 64 men with ischaemic heart disease. Plasma fibrinogen levels were found to rise markedly and progressively with age in both male and female healthy subjects; plasminogen showed only a slight rise with age. No sex differences were found for either fibrinogen or plasminogen. The correlation between plasminogen and fibrinogen levels was low, reaching the 5% level of significance only in men. Patients with ischaemic heart disease were found to have significantly increased fibrinogen and plasminogen levels in the 31-45 years age group only.
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Selected References
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- ALKJAERSIG N., FLETCHER A. P., SHERRY S. The mechanism of clot dissolution by plasmin. J Clin Invest. 1959 Jul;38(7):1086–1095. doi: 10.1172/JCI103885. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EASTHAM R. D., MORGAN E. H. PLASMA-FIBRINOGEN LEVELS IN CORONARY-ARTERY DISEASE. Lancet. 1963 Dec 7;2(7319):1196–1197. doi: 10.1016/s0140-6736(63)92923-4. [DOI] [PubMed] [Google Scholar]
- EGEBERG O. Clotting factor levels in patients with coronary atherosclerosis. Scand J Clin Lab Invest. 1962;14:253–258. [PubMed] [Google Scholar]
- HUME R. The relationship to age and cerebral vascular accidents of fibrin and fibrinolytic activity. J Clin Pathol. 1961 Mar;14:167–171. doi: 10.1136/jcp.14.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hedner U., Nilsson I. M. Determination of plasminogen in human plasma by a casein method. Thromb Diath Haemorrh. 1965 Nov 15;14(3-4):545–561. [PubMed] [Google Scholar]
- JACOBSEN C. D. THE CASEINOLYTIC METHOD FOR DETERMINATION OF PLASMINOGEN-PLASMIN IN HUMAN PLASMA AND SERUM. Scand J Clin Lab Invest. 1964;16:372–382. doi: 10.3109/00365516409060529. [DOI] [PubMed] [Google Scholar]
- KATZ A. M., McDONALD L., DAVIES B., EDGILL M. Fibrinolysis and blood coagulation in ischaemic heart-disease. Lancet. 1963 Apr 13;1(7285):801–802. doi: 10.1016/s0140-6736(63)91505-8. [DOI] [PubMed] [Google Scholar]
- McDONALD L. Coagulability of the blood in ischaemic heart-disease. Lancet. 1957 Sep 7;273(6993):457–460. doi: 10.1016/s0140-6736(57)90768-7. [DOI] [PubMed] [Google Scholar]
- Merskey C., Gordon H., Lackner H., Schrire V., Kaplan B. J., Sougin-Mibashan R., Nossel H. L., Moodie A. Blood Coagulation and Fibrinolysis in Relation to Coronary Heart Disease. Br Med J. 1960 Jan 23;1(5168):219–227. doi: 10.1136/bmj.1.5168.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NAIMI S., GOLDSTEIN R., PROGER S. Studies of coagulation and fibrinolysis of the arterial and venous blood in normal subjects and patients with atherosclerosis. Circulation. 1963 May;27:904–918. doi: 10.1161/01.cir.27.5.904. [DOI] [PubMed] [Google Scholar]
- NAKAMURA R. M., KUNITAKE G. M., FUJITA K., REILLY E. B. PLASMA-FIBRINOGEN LEVELS AFTER LONG-TERM WARFARIN THERAPY. Lancet. 1964 Oct 10;2(7363):821–822. doi: 10.1016/s0140-6736(64)90604-x. [DOI] [PubMed] [Google Scholar]
- PILGERAM L. O. Relation of plasma fibrinogen concentration changes to human arteriosclerosis. J Appl Physiol. 1961 Jul;16:660–664. doi: 10.1152/jappl.1961.16.4.660. [DOI] [PubMed] [Google Scholar]
- RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
- REMMERT L. F., COHEN P. P. Partial purification and properties of a proteolytic enzyme of human serum. J Biol Chem. 1949 Nov;181(1):431–448. [PubMed] [Google Scholar]
- SHERRY S., FLETCHER A. P., ALKJAERSIG N. Fibrinolysis and fibrinolytic activity in man. Physiol Rev. 1959 Apr;39(2):343–382. doi: 10.1152/physrev.1959.39.2.343. [DOI] [PubMed] [Google Scholar]