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. 1969 May;22(3):304–311. doi: 10.1136/jcp.22.3.304

Effects of three cobra venoms on blood coagulation, platelet aggregation, and fibrinolysis

N MacKay 1,2, J C Ferguson 1,2, G P McNicol 1,2
PMCID: PMC474066  PMID: 5814735

Abstract

The effects of the venoms of Naja melanoleuca, Naja nigricollis, and Ophiophagus hannah on blood coagulation, platelet aggregation, and fibrinolysis were studied in vitro. All three venoms were shown to be anticoagulant. This action appeared to be due to an effect on both the extrinsic and blood thromboplastin mechanisms. Platelet aggregation in Chandler's tubes and adenosine diphosphate reactivity were inhibited by the three venoms, although in the case of Ophiophagus hannah venom they were inhibited only with intermediate concentrations. The three venoms possessed proteolytic properties, but when incorporated into purified caseinolytic systems and euglobulin clot lysis systems inhibition of plasmin activity was observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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