Skip to main content
Thorax logoLink to Thorax
editorial
. 1994 Aug;49(8):738–742. doi: 10.1136/thx.49.8.738

Role of free radicals in the pathogenesis of cystic fibrosis.

R K Brown, F J Kelly
PMCID: PMC475116  PMID: 8091316

Full text

PDF
742

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ater J. L., Herbst J. J., Landaw S. A., O'Brien R. T. Relative anemia and iron deficiency in cystic fibrosis. Pediatrics. 1983 May;71(5):810–814. [PubMed] [Google Scholar]
  2. Babior B. M. The respiratory burst of phagocytes. J Clin Invest. 1984 Mar;73(3):599–601. doi: 10.1172/JCI111249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Biggs B. G., Vaughan W., Colombo J. L., Sanger W., Purtilo D. T. Cystic fibrosis complicated by acute leukemia. Cancer. 1986 Jun 15;57(12):2441–2443. doi: 10.1002/1097-0142(19860615)57:12<2441::aid-cncr2820571232>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  4. Brigham K. L. Oxidant stress and adult respiratory distress syndrome. Eur Respir J Suppl. 1990 Oct;11:482s–484s. [PubMed] [Google Scholar]
  5. Britigan B. E., Roeder T. L., Rasmussen G. T., Shasby D. M., McCormick M. L., Cox C. D. Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury. J Clin Invest. 1992 Dec;90(6):2187–2196. doi: 10.1172/JCI116104. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bye A. M., Muller D. P., Wilson J., Wright V. M., Mearns M. B. Symptomatic vitamin E deficiency in cystic fibrosis. Arch Dis Child. 1985 Feb;60(2):162–164. doi: 10.1136/adc.60.2.162-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coffman T. J., Cox C. D., Edeker B. L., Britigan B. E. Possible role of bacterial siderophores in inflammation. Iron bound to the Pseudomonas siderophore pyochelin can function as a hydroxyl radical catalyst. J Clin Invest. 1990 Oct;86(4):1030–1037. doi: 10.1172/JCI114805. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Davis T. M., Sawicka E. H. Adenocarcinoma in cystic fibrosis. Thorax. 1985 Mar;40(3):199–200. doi: 10.1136/thx.40.3.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Draper H. H., Squires E. J., Mahmoodi H., Wu J., Agarwal S., Hadley M. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic Biol Med. 1993 Oct;15(4):353–363. doi: 10.1016/0891-5849(93)90035-s. [DOI] [PubMed] [Google Scholar]
  10. Döring G., Albus A., Høiby N. Immunologic aspects of cystic fibrosis. Chest. 1988 Aug;94(2 Suppl):109S–115S. doi: 10.1378/chest.94.2_supplement.109s. [DOI] [PubMed] [Google Scholar]
  11. Feigal R. J., Shapiro B. L. Mitochondrial calcium uptake and oxygen consumption in cystic fibrosis. Nature. 1979 Mar 15;278(5701):276–277. doi: 10.1038/278276a0. [DOI] [PubMed] [Google Scholar]
  12. Fick R. B., Jr, Olchowski J., Squier S. U., Merrill W. W., Reynolds H. Y. Immunoglobulin-G subclasses in cystic fibrosis. IgG2 response to Pseudomonas aeruginosa lipopolysaccharide. Am Rev Respir Dis. 1986 Mar;133(3):418–422. doi: 10.1164/arrd.1986.133.3.418. [DOI] [PubMed] [Google Scholar]
  13. Graff I., Schram-Doumont A., Szpirer C. Defective protein kinase C-mediated actions in cystic fibrosis neutrophils. Cell Signal. 1991;3(3):259–266. doi: 10.1016/0898-6568(91)90052-v. [DOI] [PubMed] [Google Scholar]
  14. Graft D. F., Mischler E., Farrell P. M., Busse W. W. Granulocyte chemiluminescence in adolescent patients with cystic fibrosis. Am Rev Respir Dis. 1982 May;125(5):540–543. doi: 10.1164/arrd.1982.125.5.540. [DOI] [PubMed] [Google Scholar]
  15. Higson F. K., Kohen R., Chevion M. Iron enhancement of ascorbate toxicity. Free Radic Res Commun. 1988;5(2):107–115. doi: 10.3109/10715768809066918. [DOI] [PubMed] [Google Scholar]
  16. Holley A. E., Slater T. F. Measurement of lipid hydroperoxides in normal human blood plasma using HPLC-chemiluminescence linked to a diode array detector for measuring conjugated dienes. Free Radic Res Commun. 1991;15(1):51–63. doi: 10.3109/10715769109049125. [DOI] [PubMed] [Google Scholar]
  17. Homnick D. N., Cox J. H., DeLoof M. J., Ringer T. V. Carotenoid levels in normal children and in children with cystic fibrosis. J Pediatr. 1993 May;122(5 Pt 1):703–707. doi: 10.1016/s0022-3476(06)80008-9. [DOI] [PubMed] [Google Scholar]
  18. Hubbard V. S., Barbero G., Chase H. P. Selenium and cystic fibrosis. J Pediatr. 1980 Mar;96(3 Pt 1):421–422. doi: 10.1016/s0022-3476(80)80685-8. [DOI] [PubMed] [Google Scholar]
  19. Kharazmi A., Rechnitzer C., Schiøtz P. O., Jensen T., Baek L., Høiby N. Priming of neutrophils for enhanced oxidative burst by sputum from cystic fibrosis patients with Pseudomonas aeruginosa infection. Eur J Clin Invest. 1987 Jun;17(3):256–261. doi: 10.1111/j.1365-2362.1987.tb01245.x. [DOI] [PubMed] [Google Scholar]
  20. Knoppert D. C., Spino M., Beck R., Thiessen J. J., MacLeod S. M. Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease. Clin Pharmacol Ther. 1988 Sep;44(3):254–264. doi: 10.1038/clpt.1988.147. [DOI] [PubMed] [Google Scholar]
  21. Langley S. C., Brown R. K., Kelly F. J. Reduced free-radical-trapping capacity and altered plasma antioxidant status in cystic fibrosis. Pediatr Res. 1993 Mar;33(3):247–250. doi: 10.1203/00006450-199303000-00008. [DOI] [PubMed] [Google Scholar]
  22. Matkovics B., Gyurkovits K., László A., Szabó L. Altered peroxide metabolism in erythrocytes from children with cystic fibrosis. Clin Chim Acta. 1982 Oct 13;125(1):59–62. doi: 10.1016/0009-8981(82)90045-6. [DOI] [PubMed] [Google Scholar]
  23. Matthews W. J., Jr, Williams M., Oliphint B., Geha R., Colten H. R. Hypogammaglobulinemia in patients with cystic fibrosis. N Engl J Med. 1980 Jan 31;302(5):245–249. doi: 10.1056/NEJM198001313020501. [DOI] [PubMed] [Google Scholar]
  24. Meyer K. C., Lewandoski J. R., Zimmerman J. J., Nunley D., Calhoun W. J., Dopico G. A. Human neutrophil elastase and elastase/alpha 1-antiprotease complex in cystic fibrosis. Comparison with interstitial lung disease and evaluation of the effect of intravenously administered antibiotic therapy. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):580–585. doi: 10.1164/ajrccm/144.3_Pt_1.580. [DOI] [PubMed] [Google Scholar]
  25. Meyer K. C., Zimmerman J. Neutrophil mediators, Pseudomonas, and pulmonary dysfunction in cystic fibrosis. J Lab Clin Med. 1993 May;121(5):654–661. [PubMed] [Google Scholar]
  26. Owen S., Pearson D., Suarez-Mendez V., O'Driscoll R., Woodcock A. Evidence of free-radical activity in asthma. N Engl J Med. 1991 Aug 22;325(8):586–587. doi: 10.1056/NEJM199108223250816. [DOI] [PubMed] [Google Scholar]
  27. Roberts R. L., Stiehm E. R. Increased phagocytic cell chemiluminescence in patients with cystic fibrosis. Am J Dis Child. 1989 Aug;143(8):944–950. doi: 10.1001/archpedi.1989.02150200104027. [DOI] [PubMed] [Google Scholar]
  28. Salh B., Webb K., Guyan P. M., Day J. P., Wickens D., Griffin J., Braganza J. M., Dormandy T. L. Aberrant free radical activity in cystic fibrosis. Clin Chim Acta. 1989 Apr 28;181(1):65–74. doi: 10.1016/0009-8981(89)90318-5. [DOI] [PubMed] [Google Scholar]
  29. Smith C. V., Hansen T. N., Martin N. E., McMicken H. W., Elliott S. J. Oxidant stress responses in premature infants during exposure to hyperoxia. Pediatr Res. 1993 Sep;34(3):360–365. doi: 10.1203/00006450-199309000-00024. [DOI] [PubMed] [Google Scholar]
  30. Stead R. J., Redington A. N., Hinks L. J., Clayton B. E., Hodson M. E., Batten J. C. Selenium deficiency and possible increased risk of carcinoma in adults with cystic fibrosis. Lancet. 1985 Oct 19;2(8460):862–863. doi: 10.1016/s0140-6736(85)90127-8. [DOI] [PubMed] [Google Scholar]
  31. Tedesco F. J., Brown R., Schuman B. M. Pancreatic carcinoma in a patient with cystic fibrosis. Gastrointest Endosc. 1986 Feb;32(1):25–26. doi: 10.1016/s0016-5107(86)71723-9. [DOI] [PubMed] [Google Scholar]
  32. Turrens J. F., Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J. 1980 Nov 1;191(2):421–427. doi: 10.1042/bj1910421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Weiss S. J. Tissue destruction by neutrophils. N Engl J Med. 1989 Feb 9;320(6):365–376. doi: 10.1056/NEJM198902093200606. [DOI] [PubMed] [Google Scholar]
  34. Wisnieski J. J., Todd E. W., Fuller R. K., Jones P. K., Dearborn D. G., Boat T. F., Naff G. B. Immune complexes and complement abnormalities in patients with cystic fibrosis. Increased mortality associated with circulating immune complexes and decreased function of the alternative complement pathway. Am Rev Respir Dis. 1985 Oct;132(4):770–776. doi: 10.1164/arrd.1985.132.4.770. [DOI] [PubMed] [Google Scholar]
  35. Yagi K. Assay for blood plasma or serum. Methods Enzymol. 1984;105:328–331. doi: 10.1016/s0076-6879(84)05042-4. [DOI] [PubMed] [Google Scholar]
  36. von Ruecker A. A., Bertele R., Harms H. K. Calcium metabolism and cystic fibrosis: mitochondrial abnormalities suggest a modification of the mitochondrial membrane. Pediatr Res. 1984 Jul;18(7):594–599. doi: 10.1203/00006450-198407000-00005. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES